Proteins

Genome: KpATCC43816

Description: Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome

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# Protein Description Gene Structure EC GO Metabolism Druggability (P2Rank) P2RANK ligandability score for the best pocket in the experimental structure (0–1). Higher values indicate higher predicted ligandability. Available only for genomes analyzed with the curated pipeline. Druggability (FPocket) FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
2051 VK055_0320 feS assembly protein SufB sufB AlphaFold DB model + ColabFold model –
GO:0016226The incorporation of iron and exogenous sulfur into a metallo-sulfur cluster.
No map 0.680 0.666 No Hit 0.0% —
2052 VK055_3306 molybdopterin-guanine dinucleotide biosynthesis protein A mobA AlphaFold DB model + ColabFold model –
GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0006777The chemical reactions and pathways resulting in the formation of the Mo-molybdopterin cofactor, essential for the catalytic activity of some enzymes. The cofactor consists of a mononuclear molybdenum (Mo) ion coordinated by one or two molybdopterin ligands.
Mapped 1 0.679 0.5 No Hit 0.0% —
2053 VK055_2278 gram-negative porin family protein AlphaFold DB model + ColabFold model –
GO:0015288Enables the transfer of substances, sized less than 1000 Da, from one side of a membrane to the other. The transmembrane portions of porins consist exclusively of beta-strands which form a beta-barrel. They are found in the outer membranes of Gram-negative bacteria, mitochondria, plastids and possibly acid-fast Gram-positive bacteria. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0009279A lipid bilayer that forms the outermost membrane of the cell envelope; enriched in polysaccharide and protein; the outer leaflet of the membrane contains specific lipopolysaccharide structures. +25 total
No map 0.679 0.996 No Hit 0.0% —
2054 VK055_0297 phosphoenolpyruvate synthase ppsA AlphaFold DB model + ColabFold model –
GO:0016772Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor). GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. +47 total
Mapped 1 0.679 0.453 No Hit 0.0% —
2055 VK055_5051 exonuclease I, 3' -- 5' specific deoxyribophosphodiesterase AlphaFold DB model + ColabFold model
3.1.11.1
GO:0003676Binding to a nucleic acid. GO:0004529Catalysis of the sequential cleavage of mononucleotides from a free 5' or 3' terminus of a DNA molecule. GO:0000175Catalysis of the sequential cleavage of mononucleotides from a free 3' terminus of an RNA molecule. +47 total
No map 0.678 0.468 No Hit 0.0% —
2056 VK055_0087 protease II AlphaFold DB model + ColabFold model
3.4.21.83
GO:0008236Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). GO:0004252Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). GO:0006508The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds.
No map 0.678 0.163 Hit 27.0% 7.06e-48
2057 VK055_4954 &beta-D-glucoside glucohydrolase, periplasmic AlphaFold DB model + ColabFold model
3.2.1.21
GO:0004553Catalysis of the hydrolysis of any O-glycosyl bond. GO:0005975The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. GO:0042597The region between the inner (cytoplasmic) and outer membrane (Gram-negative Bacteria) or cytoplasmic membrane and cell wall (Fungi and Gram-positive Bacteria). +25 total
No map 0.677 0.535 No Hit 0.0% —
2058 VK055_2980 periplasmic binding and sugar binding domain of LacI family protein AlphaFold DB model + ColabFold model – – No map 0.677 0.267 No Hit 0.0% —
2059 VK055_2865 opacity-associated A N-terminal motif family protein AlphaFold DB model + ColabFold model –
GO:0042834Interacting selectively and non-covalently, in a non-covalent manner, with peptidoglycan, any of a class of glycoconjugates found in bacterial cell walls.
No map N/A 0.677 No Hit 0.0% —
2060 VK055_2221 hypothetical protein AlphaFold DB model + ColabFold model
2.4.2.1 2.4.2.2
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0047975Catalysis of the reaction: guanosine + phosphate = alpha-D-ribose 1-phosphate + guanine. GO:0004731Catalysis of the reaction: purine nucleoside + phosphate = purine + alpha-D-ribose 1-phosphate. +25 total
No map 0.677 0.827 No Hit 0.0% —
2061 VK055_2194 protein-export membrane protein SecF secF AlphaFold DB model + ColabFold model –
GO:0015450Primary active carrier-mediated transport of a protein across a membrane, driven by the hydrolysis of the diphosphate bond of inorganic pyrophosphate, ATP, or another nucleoside triphosphate. The transport protein may or may not be transiently phosphorylated, but the substrate is not phosphorylated. GO:0006886The directed movement of proteins in a cell, including the movement of proteins between specific compartments or structures within a cell, such as organelles of a eukaryotic cell. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. +36 total
No map 0.677 0.957 No Hit 0.0% —
2062 VK055_1956 binding-protein-dependent transport system innermembrane component family protein AlphaFold DB model + ColabFold model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. +14 total
No map 0.677 0.969 No Hit 0.0% —
2063 VK055_4649 3-mercaptopyruvate sulfurtransferase sseA AlphaFold DB model + ColabFold model –
GO:0004792Catalysis of the reaction: thiosulfate + hydrogen cyanide = thiocyanate + sulfite + 2 H+. GO:0016783Catalysis of the transfer of sulfur atoms from one compound (donor) to another (acceptor). GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. +14 total
Mapped 3 0.676 0.404 Hit 42.1% 3.65e-67
2064 VK055_4000 urease accessory protein UreG ureG AlphaFold DB model + ColabFold model –
GO:0016151Binding to a nickel (Ni) cation. GO:0006807OBSOLETE. The chemical reactions and pathways involving organic or inorganic compounds that contain nitrogen. GO:0003924Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate.
No map 0.676 0.565 No Hit 0.0% —
2065 VK055_1232 periplasmic protein related to spheroblast formation AlphaFold DB model + ColabFold model –
GO:0042597The region between the inner (cytoplasmic) and outer membrane (Gram-negative Bacteria) or cytoplasmic membrane and cell wall (Fungi and Gram-positive Bacteria).
No map N/A 0.676 No Hit 0.0% —
2066 VK055_0897 H+ symporter family protein AlphaFold DB model + ColabFold model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0015128Enables the transfer of gluconate from one side of a membrane to the other. Gluconate is the aldonic acid derived from glucose. GO:0035429The process in which gluconate is transported across a membrane. Gluconate is the aldonic acid derived from glucose. +14 total
No map 0.676 0.721 No Hit 0.0% —
2067 VK055_0136 tellurite resistance protein B tehB AlphaFold DB model + ColabFold model – – No map 0.676 0.874 No Hit 0.0% —
2068 VK055_2859 NAD(P)H:quinone oxidoreductase ytfG AlphaFold DB model + ColabFold model – – No map 0.675 0.785 Hit 27.3% 8.47e-06
2069 VK055_1925 ENTC isochorismate synthase 1 entC AlphaFold DB model + ColabFold model
5.4.4.2
GO:0009058A cellular process consisting of the biochemical pathways by which a living organism synthesizes chemical substances. This typically represents the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. GO:0008909Catalysis of the reaction: chorismate = isochorismate. GO:0046872Binding to a metal ion. +14 total
No map 0.675 0.7 No Hit 0.0% —
2070 VK055_0274 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.675 0.724 No Hit 0.0% —
2071 VK055_5029 nucleotide sugar dehydrogenase family protein ugd Experimental + ColabFold model
1.1.1.22
GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. GO:0000271The chemical reactions and pathways resulting in the formation of a polysaccharide, a polymer of many (typically more than 10) monosaccharide residues linked glycosidically. GO:0051287Binding to nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD+, or the reduced form, NADH. +36 total
No map 0.674 0.951 Hit 31.7% 4.61e-06
2072 VK055_3354 putative transcriptional regulator LysR-type AlphaFold DB model + ColabFold model –
GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
No map 0.674 0.822 No Hit 0.0% —
2073 VK055_1562 outer membrane lipocarrier protein LolA lolA AlphaFold DB model + ColabFold model –
GO:0042953The directed movement of any conjugated, water-soluble protein in which the nonprotein group consists of a lipid or lipids, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. GO:0042597The region between the inner (cytoplasmic) and outer membrane (Gram-negative Bacteria) or cytoplasmic membrane and cell wall (Fungi and Gram-positive Bacteria). GO:0030288The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin peptidoglycan layer (PGL), also referred to as a thin cell wall. +14 total
No map 0.674 0.454 No Hit 0.0% —
2074 VK055_0697 guanine deaminase guaD AlphaFold DB model + ColabFold model
3.5.4.3
GO:0016810Catalysis of the hydrolysis of any carbon-nitrogen bond, C-N, with the exception of peptide bonds. GO:0006147The chemical reactions and pathways resulting in the breakdown of guanine, 2-amino-6-hydroxypurine, a purine that is one of the five main bases found in nucleic acids and a component of a number of phosphorylated guanosine derivatives whose metabolic or regulatory functions are important. GO:0008892Catalysis of the reaction: guanine + H2O + H+ = xanthine + NH4+. +36 total
Chokepoint 3 0.674 0.634 Hit 37.3% 6.25e-25
2075 VK055_0672 lysE type translocator family protein AlphaFold DB model + ColabFold model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0006865The directed movement of amino acids, organic acids containing one or more amino substituents, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. +14 total
No map 0.674 0.954 No Hit 0.0% —
Page of 204 · 5081 total proteins