Proteins

Genome: KpATCC43816

Description: Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome

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# Protein Description Gene Structure EC GO Metabolism Druggability (P2Rank) P2RANK ligandability score for the best pocket in the experimental structure (0–1). Higher values indicate higher predicted ligandability. Available only for genomes analyzed with the curated pipeline. Druggability (FPocket) FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
2001 VK055_4837 NADH:ubiquinone oxidoreductase, membrane subunitA nuoA AlphaFold DB model + ColabFold model
7.1.1.-
GO:0008137Catalysis of the reaction: NADH + ubiquinone + 5 H+(in) = NAD+ + ubiquinol + 4 H+(out). GO:0030964An integral membrane complex that possesses NADH oxidoreductase activity. The complex is one of the components of the electron transport chain. It catalyzes the transfer of a pair of electrons from NADH to a quinone. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. +14 total
Mapped 3 N/A 0.692 Hit 48.6% 1.22e-06
2002 VK055_1185 hypothetical protein AlphaFold DB model + ColabFold model – – No map N/A 0.692 No Hit 0.0% —
2003 VK055_0967 beta-ketoadipate pathway transcriptional regulator, PcaR/PcaU/PobR family protein AlphaFold DB model + ColabFold model –
GO:0045893Any process that activates or increases the frequency, rate or extent of cellular DNA-templated transcription. GO:0046278The chemical reactions and pathways involving protocatechuate, the anion of protocatechuic acid (3,4-dihydroxybenzoic acid). GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). +14 total
No map 0.692 0.875 No Hit 0.0% —
2004 VK055_0552 fused predicted DNA-binding transcriptional regulator and predicted amino transferase AlphaFold DB model + ColabFold model –
GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. +47 total
Mapped 1 0.692 0.923 Hit 26.0% 5.64e-13
2005 VK055_3390 hypothetical protein ColabFold model – – No map N/A 0.691 No Hit 0.0% —
2006 VK055_2558 na+/H+ antiporter NhaA nhaA AlphaFold DB model + ColabFold model –
GO:0006885Any process involved in the maintenance of an internal equilibrium of hydrogen ions, thereby modulating the internal pH, within an organism or cell. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0006814The directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. +25 total
No map 0.691 0.817 No Hit 0.0% —
2007 VK055_1079 metallo-beta-lactamase superfamily protein AlphaFold DB model + ColabFold model –
GO:0016787Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. GO:0046872Binding to a metal ion.
No map 0.691 0.754 No Hit 0.0% —
2008 VK055_1074 NLPA lipofamily protein AlphaFold DB model + ColabFold model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
No map 0.691 0.74 No Hit 0.0% —
2009 VK055_1029 phenylacetic acid degradation protein PaaY paaY AlphaFold DB model + ColabFold model –
GO:0016740Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2.
No map 0.691 0.482 No Hit 0.0% —
2010 VK055_2975 phosphonate metabolism protein PhnP phnP AlphaFold DB model + ColabFold model –
GO:0019700The chemical reactions and pathways resulting in the breakdown of phosphonates, any organic compound containing one or more C-PO(OH)2 or C-PO(OR)2 (with R=alkyl, aryl) groups. Catabolism of phosphonic acid itself, an inorganic compound without the biochemically relevant C-P bond, is not included. GO:0008081Catalysis of the hydrolysis of a phosphodiester to give a phosphomonoester and a free hydroxyl group.
No map 0.690 0.297 No Hit 0.0% —
2011 VK055_1253 acid phosphatase pho AlphaFold DB model + ColabFold model
3.1.3.2
GO:0030288The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin peptidoglycan layer (PGL), also referred to as a thin cell wall. GO:0003993Catalysis of the reaction: an orthophosphoric monoester + H2O = an alcohol + phosphate, with an acid pH optimum.
Mapped 2 0.690 0.344 No Hit 0.0% —
2012 VK055_0455 binding-protein-dependent transport system innermembrane component family protein AlphaFold DB model + ColabFold model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
No map 0.690 0.391 No Hit 0.0% —
2013 VK055_3546 glycyl-tRNA synthetase alpha subunit glyQ AlphaFold DB model + ColabFold model
6.1.1.14
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0004820Catalysis of the reaction: ATP + glycine + tRNA(Gly) = AMP + diphosphate + glycyl-tRNA(Gly). GO:0006426The process of coupling glycine to glycyl-tRNA, catalyzed by glycyl-tRNA synthetase. The glycyll-tRNA synthetase is a class-II synthetase. The activated amino acid is transferred to the 3'-OH group of a glycine-accepting tRNA. +36 total
Mapped 1 0.689 0.376 No Hit 0.0% —
2014 VK055_0413 acetyl-CoA C-acetyltransferase family protein AlphaFold DB model + ColabFold model
2.3.1.9
GO:0016747Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). GO:0016746Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor). GO:0003985Catalysis of the reaction: 2 acetyl-CoA = CoA + acetoacetyl-CoA. +14 total
No map 0.689 0.97 Hit 51.7% 7.60e-133
2015 VK055_4295 peptidase M16 inactive domain protein AlphaFold DB model + ColabFold model
3.4.24.55
GO:0004222Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. GO:0006508The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds. GO:0046872Binding to a metal ion. +14 total
No map 0.688 0.797 Hit 34.0% 5.05e-06
2016 VK055_4246 fimbrial family protein AlphaFold DB model + ColabFold model –
GO:0007155The attachment of a cell, either to another cell or to an underlying substrate such as the extracellular matrix, via cell adhesion molecules. GO:0009289A proteinaceous hair-like appendage on the surface of bacteria ranging from 2-8 nm in diameter. GO:0043709The attachment of a cell to a solid substrate, via cell adhesion molecules, during the formation of a biofilm composed of microorganisms of the same species.
No map 0.688 0.276 No Hit 0.0% —
2017 VK055_2642 sodium:solute symporter family protein AlphaFold DB model + ColabFold model –
GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. +36 total
No map 0.688 0.763 Hit 28.0% 9.59e-06
2018 VK055_1174 pyrF pyrF Experimental + ColabFold model
4.1.1.23
GO:0004590Catalysis of the reaction: H+ + orotidine 5'-phosphate = CO2 + UMP. GO:0006207The chemical reactions and pathways resulting in the formation of pyrimidine nucleobases, 1,3-diazine, organic nitrogenous bases, beginning with the synthesis of a pyrimidine ring from simpler precursors. GO:0044205The chemical reactions and pathways resulting in the formation of UMP, uridine monophosphate, starting with the synthesis of (S)-dihydroorotate from bicarbonate; UMP biosynthesis may either occur via reduction by quinone, NAD+ or oxygen. +14 total
Chokepoint 1 0.688 0.65 No Hit 0.0% —
2019 VK055_2214 hypothetical protein AlphaFold DB model + ColabFold model – – No map N/A 0.687 No Hit 0.0% —
2020 VK055_0699 bacterial regulatory, gntR family protein AlphaFold DB model + ColabFold model –
GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
No map 0.687 0.412 No Hit 0.0% —
2021 VK055_0251 H-NS transcriptional dual regulator hns AlphaFold DB model + ColabFold model –
GO:0030527The action of a molecule that contributes to the structural integrity of chromatin. GO:0046983The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). +811 total
No map N/A 0.687 No Hit 0.0% —
2022 VK055_0237 hypothetical protein ColabFold model – – No map N/A 0.687 No Hit 0.0% —
2023 VK055_4955 substrate binding domain of ABC-type glycine betaine transport system family protein AlphaFold DB model + ColabFold model –
GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0043190A complex for the transport of metabolites into and out of the cell, typically comprised of four domains; two membrane-associated domains and two ATP-binding domains at the intracellular face of the membrane, that form a central pore through the plasma membrane. Each of the four core domains may be encoded as a separate polypeptide or the domains can be fused in any one of a number of ways into multidomain polypeptides. In Bacteria and Archaebacteria, ABC transporters also include substrate binding proteins to bind substrate external to the cytoplasm and deliver it to the transporter. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.
No map 0.686 0.28 No Hit 0.0% —
2024 VK055_4594 acetyltransferase family protein AlphaFold DB model + ColabFold model –
GO:0016747Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
No map 0.686 0.432 No Hit 0.0% —
2025 VK055_3166 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.686 0.478 No Hit 0.0% —
Page of 204 · 5081 total proteins