Proteins

Genome: KpATCC43816

Description: Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome

Search, filter, and prioritize proteins.

Export view
5081 / 5081 proteins
No filters or custom sorting applied — click to see defaults

Scoring formula None

Sorted by Druggability (P2Rank preferred) (descending)

Applied filters No active filters

Search query No active search

Rows per page 25

Rows
# Protein Description Gene Structure EC GO Metabolism Druggability (P2Rank) P2RANK ligandability score for the best pocket in the experimental structure (0–1). Higher values indicate higher predicted ligandability. Available only for genomes analyzed with the curated pipeline. Druggability (FPocket) FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
2076 VK055_4514 hypothetical protein AlphaFold DB model + ColabFold model –
GO:0051920Catalysis of the reaction: [protein]-dithol + ROOH = [protein]-disulfide + H2O + ROH.
No map 0.673 0.634 No Hit 0.0% —
2077 VK055_3487 SMP-30/Gluconolaconase/LRE-like region family protein ColabFold model – – No map 0.673 0.314 Hit 25.7% 1.71e-10
2078 VK055_1145 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.673 0.602 No Hit 0.0% —
2079 VK055_4777 hypothetical protein AlphaFold DB model + ColabFold model – – No map N/A 0.672 No Hit 0.0% —
2080 VK055_2619 hypothetical protein AlphaFold DB model + ColabFold model –
GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.
No map 0.672 0.523 No Hit 0.0% —
2081 VK055_1994 helix-turn-helix domain protein AlphaFold DB model + ColabFold model –
GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
No map 0.672 0.391 No Hit 0.0% —
2082 VK055_1700 DEAD-box-containing ATP-dependent RNA helicase family member AlphaFold DB model + ColabFold model –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0042255The aggregation, arrangement and bonding together of the mature ribosome and of its subunits. GO:0003676Binding to a nucleic acid. +14 total
No map 0.672 0.192 Hit 54.2% 5.59e-13
2083 VK055_1247 hypothetical protein AlphaFold DB model + ColabFold model –
GO:0006281The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. GO:0016787Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc.
No map 0.672 0.648 No Hit 0.0% —
2084 VK055_4658 outer membrane assembly lipoprotein YfgL yfgL Experimental + ColabFold model –
GO:0005515Binding to a protein. GO:0009279A lipid bilayer that forms the outermost membrane of the cell envelope; enriched in polysaccharide and protein; the outer leaflet of the membrane contains specific lipopolysaccharide structures. GO:0043165The assembly of an outer membrane of the type formed in Gram-negative bacteria. This membrane is enriched in polysaccharide and protein, and the outer leaflet of the membrane contains specific lipopolysaccharide structures. +14 total
No map 0.671 0.438 No Hit 0.0% —
2085 VK055_2632 AAA domain family protein AlphaFold DB model + ColabFold model –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0008134Binding to a transcription factor, a protein required to initiate or regulate transcription. +47 total
No map 0.671 0.457 No Hit 0.0% —
2086 VK055_2030 hypothetical protein AlphaFold DB model + ColabFold model – – No map N/A 0.671 No Hit 0.0% —
2087 VK055_1944 L-fucose isomerase, C-terminal domain protein AlphaFold DB model + ColabFold model –
GO:0005996The chemical reactions and pathways involving monosaccharides, the simplest carbohydrates. They are polyhydric alcohols containing either an aldehyde or a keto group and between three to ten or more carbon atoms. They form the constitutional repeating units of oligo- and polysaccharides. GO:0008736Catalysis of the reaction: L-fucose = L-fuculose. GO:0016861Catalysis of an oxidation-reduction (redox) reaction in which the hydrogen donor and acceptor, which is an aldose or a ketose, are the same molecule, and no oxidized product appears. +25 total
No map 0.671 0.69 No Hit 0.0% —
2088 VK055_1760 hypothetical protein AlphaFold DB model + ColabFold model –
GO:0042910Enables the directed movement of a xenobiotic from one side of a membrane to the other. A xenobiotic is a compound foreign to the organism exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical. GO:1990961A process that reduces or removes the toxicity of a xenobiotic by exporting it outside the cell. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. +14 total
No map N/A 0.671 No Hit 0.0% —
2089 VK055_1262 methionine sulfoxide reductase B msrB AlphaFold DB model + ColabFold model
1.8.4.12
GO:0030091The process of restoring a protein to its original state after damage by such things as oxidation or spontaneous decomposition of residues. GO:0016671Catalysis of an oxidation-reduction (redox) reaction in which a sulfur-containing group acts as a hydrogen or electron donor and reduces disulfide. GO:0033743Catalysis of the reaction: L-methionyl-[protein] + [thioredoxin]-disulfide + H2O = L-methionyl-(R)-S-oxide-[protein] + [thioredoxin]-dithiol. +36 total
No map 0.671 0.544 Hit 56.2% 1.20e-13
2090 VK055_0304 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.671 0.223 No Hit 0.0% —
2091 VK055_0139 hypothetical protein AlphaFold DB model + ColabFold model – – No map N/A 0.671 No Hit 0.0% —
2092 VK055_5070 non-heme chloroperoxidase cpo AlphaFold DB model + ColabFold model – – Mapped 1 0.670 0.878 Hit 30.7% 9.10e-06
2093 VK055_4744 bacterial regulatory, gntR family protein AlphaFold DB model + ColabFold model –
GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. +36 total
No map 0.670 0.336 Hit 26.1% 3.27e-07
2094 VK055_4016 glnD PII-uridylyltransferase family protein AlphaFold DB model + ColabFold model –
GO:0016779Catalysis of the transfer of a nucleotidyl group from one compound (donor) to another (acceptor). GO:0008882Catalysis of the reaction: ATP + [L-glutamate:ammonia ligase (ADP-forming)] = diphosphate + adenylyl-[L-glutamate:ammonia ligase (ADP-forming)].
No map 0.670 0.458 No Hit 0.0% —
2095 VK055_3824 modulator of DNA gyrase family protein AlphaFold DB model + ColabFold model –
GO:0008237Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. GO:0006508The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
No map 0.670 0.455 No Hit 0.0% —
2096 VK055_1062 ATP-dependent RNA helicase, specific for 23S rRNA AlphaFold DB model + ColabFold model
3.6.4.13
GO:0000027The aggregation, arrangement and bonding together of constituent RNAs and proteins to form the large ribosomal subunit. GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0003676Binding to a nucleic acid. +58 total
No map 0.670 0.797 Hit 50.5% 6.67e-20
2097 VK055_5080 putative mobilization protein AlphaFold DB model + ColabFold model – – No map 0.669 0.719 No Hit 0.0% —
2098 VK055_4299 amino-acid N-acetyltransferase argA AlphaFold DB model + ColabFold model
2.3.1.1
GO:0016747Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). GO:0006526The chemical reactions and pathways resulting in the formation of arginine, 2-amino-5-(carbamimidamido)pentanoic acid. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. +25 total
Chokepoint 2 0.669 0.919 No Hit 0.0% —
2099 VK055_2426 2-amino-4-hydroxy-6- hydroxymethyldihydropteridine diphosphokinase folK AlphaFold DB model + ColabFold model
2.7.6.3
GO:0003848Catalysis of the reaction: 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine + ATP = (2-amino-4-hydroxy-7,8-dihydropteridin-6-yl)methyl diphosphate + AMP + 2 H+. GO:0009396The chemical reactions and pathways resulting in the formation of folic acid and its derivatives. GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. +36 total
Chokepoint 2 0.669 0.288 No Hit 0.0% —
2100 VK055_0109 yebO-like family protein AlphaFold DB model + ColabFold model –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
No map N/A 0.669 No Hit 0.0% —
Page of 204 · 5081 total proteins