Proteins

Genome: KpATCC43816

Description: Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome

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5081 proteins

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# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
2076 VK055_1174 pyrF pyrF Experimental + ColabFold
4.1.1.23
GO:0004590Catalysis of the reaction: H+ + orotidine 5'-phosphate = CO2 + UMP. GO:0006207The chemical reactions and pathways resulting in the formation of pyrimidine nucleobases, 1,3-diazine, organic nitrogenous bases, beginning with the synthesis of a pyrimidine ring from simpler precursors. GO:0044205The chemical reactions and pathways resulting in the formation of UMP, uridine monophosphate, starting with the synthesis of (S)-dihydroorotate from bicarbonate; UMP biosynthesis may either occur via reduction by quinone, NAD+ or oxygen. +14 total
0.65 No Hit 0.0% —
2077 VK055_0929 hypothetical protein AlphaFold + ColabFold – – 0.65 No Hit 0.0% —
2078 VK055_4475 glucitol operon activator family protein AlphaFold + ColabFold – – 0.649 No Hit 0.0% —
2079 VK055_3977 dhaR transcriptional dual regulator AlphaFold + ColabFold –
GO:0043565Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0008134Binding to a transcription factor, a protein required to initiate or regulate transcription. +36 total
0.649 No Hit 0.0% —
2080 VK055_3304 serine/threonine protein kinase AlphaFold + ColabFold
2.7.11.1
GO:0006468The process of introducing a phosphate group on to a protein. GO:0004674Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. +36 total
0.649 No Hit 0.0% —
2081 VK055_2733 PAAR motif family protein AlphaFold + ColabFold – – 0.649 No Hit 0.0% —
2082 VK055_2694 hypothetical protein AlphaFold + ColabFold – – 0.649 No Hit 0.0% —
2083 VK055_2052 adiC yjdE AlphaFold + ColabFold –
GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. +25 total
0.649 Hit 26.4% 1.56e-06
2084 VK055_1080 bacterial regulatory helix-turn-helix, lysR family protein AlphaFold + ColabFold –
GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
0.649 No Hit 0.0% —
2085 VK055_5058 S-adenosyl-L-homocysteine hydrolase, NAD bindingdomain protein AlphaFold + ColabFold –
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0004013Catalysis of the reaction: S-adenosyl-L-homocysteine + H2O = adenosine + L-homocysteine. GO:0006730The chemical reactions and pathways involving the transfer of one-carbon units in various oxidation states. +14 total
0.648 Hit 32.7% 2.20e-39
2086 VK055_3435 hypothetical protein AlphaFold + ColabFold –
GO:0051920Catalysis of the reaction: [protein]-dithol + ROOH = [protein]-disulfide + H2O + ROH.
0.648 No Hit 0.0% —
2087 VK055_2737 hypothetical protein AlphaFold + ColabFold – – 0.648 No Hit 0.0% —
2088 VK055_2121 binding-protein-dependent transport system innermembrane component family protein AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. +25 total
0.648 No Hit 0.0% —
2089 VK055_1624 hypothetical protein AlphaFold + ColabFold – – 0.648 No Hit 0.0% —
2090 VK055_1247 hypothetical protein AlphaFold + ColabFold –
GO:0006281The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. GO:0016787Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc.
0.648 No Hit 0.0% —
2091 VK055_0691 transcriptional activator, TenA family AlphaFold + ColabFold
3.5.99.2
GO:0006772The chemical reactions and pathways involving thiamine (vitamin B1), a water soluble vitamin present in fresh vegetables and meats, especially liver. GO:0050334Catalysis of the reaction: H2O + thiamine = 4-amino-5-hydroxymethyl-2-methylpyrimidine + 5-(2-hydroxyethyl)-4-methylthiazole + H+. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. +25 total
0.648 No Hit 0.0% —
2092 VK055_4121 aldehyde dehydrogenase family protein AlphaFold + ColabFold –
GO:0016620Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces NAD or NADP. GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.
0.647 Hit 56.4% 5.05e-06
2093 VK055_3139 hypothetical protein AlphaFold + ColabFold – – 0.647 No Hit 0.0% —
2094 VK055_2853 araC araC3 AlphaFold + ColabFold –
GO:0043565Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
0.647 No Hit 0.0% —
2095 VK055_0650 hypothetical protein AlphaFold + ColabFold – – 0.647 No Hit 0.0% —
2096 VK055_0292 hypothetical protein AlphaFold + ColabFold – – 0.647 Hit 44.4% 2.96e-95
2097 VK055_0288 metQ metQ AlphaFold + ColabFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
0.647 No Hit 0.0% —
2098 VK055_2390 dgt dgt AlphaFold + ColabFold
3.1.5.1
GO:0008832Catalysis of the reaction: dGTP + H2O = 2'-deoxyguanosine + 2 H+ + triphosphate. GO:0006203The chemical reactions and pathways resulting in the breakdown of dGTP, guanosine triphosphate. GO:0016793Catalysis of the hydrolysis of a triphosphoester to give a triphosphate group and a free hydroxyl group. +14 total
0.646 No Hit 0.0% —
2099 VK055_2196 preprotein translocase, YajC subunit yajC AlphaFold + ColabFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0015031The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
0.646 No Hit 0.0% —
2100 VK055_0989 DNA replication terminus site-binding protein tus AlphaFold + ColabFold –
GO:0006274The process in which DNA replication at a replication fork ceases; occurs when the replication fork reaches a specific termination site or when two replication forks meet. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
0.646 No Hit 0.0% —
Page of 204 · 5081 total proteins