Proteins

Genome: KpATCC43816

Description: Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome

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# Protein Description Gene Structure EC GO Metabolism Druggability (P2Rank) P2RANK ligandability score for the best pocket in the experimental structure (0–1). Higher values indicate higher predicted ligandability. Available only for genomes analyzed with the curated pipeline. Druggability (FPocket) FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
2201 VK055_1735 histidine ammonia-lyase hutH AlphaFold DB model + ColabFold model
4.3.1.3
GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0016841Catalysis of the release of ammonia by the cleavage of a carbon-nitrogen bond or the reverse reaction with ammonia as a substrate. GO:0006548The chemical reactions and pathways resulting in the breakdown of L-histidine. +47 total
Chokepoint 1 0.637 0.438 Hit 50.3% 3.08e-36
2202 VK055_0992 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.637 0.885 No Hit 0.0% —
2203 VK055_3353 putative phosphopantetheinyl transferase AlphaFold DB model + ColabFold model –
GO:0008897Catalysis of the reaction: CoA + substrate-serine = adenosine 3',5'-bisphosphate + substrate-serine-4'-phosphopantetheine. The transfer of the 4'-phosphopantetheine (Ppant) co-factor from coenzyme A to the hydroxyl side chain of the serine residue of acyl- or peptidyl-carrier protein (ACP or PCP) to convert them from the apo to the holo form. GO:0000287Binding to a magnesium (Mg) ion.
No map 0.636 0.014 No Hit 0.0% —
2204 VK055_3243 O-succinylhomoserine (thiol)-lyase metB AlphaFold DB model + ColabFold model –
GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0019346The interconversion of homocysteine and cysteine via cystathionine. In contrast with enteric bacteria and mammals, Saccharomyces cerevisiae has two transsulfuration pathways employing two separate sets of enzymes. GO:0030170Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. +47 total
Mapped 3 0.636 0.835 Hit 41.9% 1.26e-88
2205 VK055_3184 TDP-4-keto-6-deoxy-D-glucose transaminase familyprotein wecE Experimental + ColabFold model –
GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0019180Catalysis of the reaction: dTDP-4-amino-4,6-dideoxy-alpha-D-galactose + 2-oxoglutarate = dTDP-4-dehydro-6-deoxy-alpha-D-glucose + L-glutamate. GO:0009246The chemical reactions and pathways resulting in the formation of the enterobacterial common antigen, an acidic polysaccharide containing N-acetyl-D-glucosamine, N-acetyl-D-mannosaminouronic acid, and 4-acetamido-4,6-dideoxy-D-galactose. A major component of the cell wall outer membrane of Gram-negative bacteria.
No map 0.636 0.997 No Hit 0.0% —
2206 VK055_1100 type VI secretion ATPase, ClpV1 family clpV AlphaFold DB model + ColabFold model –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. +36 total
No map 0.636 0.394 Hit 35.3% 4.68e-39
2207 VK055_0964 3-oxoadipate CoA-transferase subunit B catJ AlphaFold DB model + ColabFold model –
GO:0008410Catalysis of the transfer of a coenzyme A (CoA) group from one compound (donor) to another (acceptor).
Chokepoint 2 0.636 0.362 Hit 44.7% 7.51e-54
2208 VK055_4175 bacterial regulatory, luxR family protein AlphaFold DB model + ColabFold model –
GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0000160A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins.
No map 0.635 0.832 No Hit 0.0% —
2209 VK055_3463 triose-phosphate isomerase tpiA2 AlphaFold DB model + ColabFold model
5.3.1.1
GO:0006096The chemical reactions and pathways resulting in the breakdown of a carbohydrate into pyruvate, with the concomitant production of a small amount of ATP and the reduction of NAD(P) to NAD(P)H. Glycolysis begins with the metabolism of a carbohydrate to generate products that can enter the pathway and ends with the production of pyruvate. Pyruvate may be converted to acetyl-coenzyme A, ethanol, lactate, or other small molecules. GO:0004807Catalysis of the reaction: D-glyceraldehyde 3-phosphate = dihydroxyacetone phosphate. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. +36 total
Mapped 1 0.635 0.766 Hit 57.6% 1.74e-06
2210 VK055_3446 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.635 0.869 No Hit 0.0% —
2211 VK055_1171 hypothetical protein AlphaFold DB model + ColabFold model – – No map N/A 0.635 No Hit 0.0% —
2212 VK055_4387 23S rRNA (uracil-5-)-methyltransferase RumA rumA AlphaFold DB model + ColabFold model
2.1.1.190
GO:0006396Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. GO:0008173Catalysis of the transfer of a methyl group from a donor to a nucleoside residue in an RNA molecule. GO:0003723Binding to an RNA molecule or a portion thereof. +47 total
Mapped 1 0.634 0.677 Hit 34.6% 4.90e-20
2213 VK055_3449 &alpha-xylosidase AlphaFold DB model + ColabFold model
3.2.1.177
GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0030246Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates. GO:0004553Catalysis of the hydrolysis of any O-glycosyl bond. +25 total
No map 0.634 0.212 Hit 29.8% 9.09e-42
2214 VK055_2422 sugar fermentation stimulation protein sfsA AlphaFold DB model + ColabFold model –
GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
No map 0.634 0.296 No Hit 0.0% —
2215 VK055_3712 DNA adenine methylase dam3 AlphaFold DB model + ColabFold model
2.1.1.72
GO:0003676Binding to a nucleic acid. GO:0008168Catalysis of the transfer of a methyl group to an acceptor molecule. GO:0009007Catalysis of the reaction: S-adenosyl-L-methionine + DNA adenine = S-adenosyl-L-homocysteine + DNA 6-methylaminopurine. +710 total
Mapped 1 0.633 0.386 No Hit 0.0% —
2216 VK055_2257 hypothetical protein ColabFold model – – No map N/A 0.633 No Hit 0.0% —
2217 VK055_2059 putative aTP-NAD/AcoX kinase AlphaFold DB model + ColabFold model – – Mapped 1 N/A 0.633 No Hit 0.0% —
2218 VK055_4856 o-succinylbenzoate synthase menC AlphaFold DB model + ColabFold model
4.2.1.113
GO:0000287Binding to a magnesium (Mg) ion. GO:0009234The chemical reactions and pathways resulting in the formation of any of the menaquinones. Structurally, menaquinones consist of a methylated naphthoquinone ring structure and side chains composed of a variable number of unsaturated isoprenoid residues. Menaquinones that have vitamin K activity and are known as vitamin K2. GO:0016836Catalysis of the cleavage of a carbon-oxygen bond by elimination of water. +14 total
Chokepoint 1 0.632 0.619 No Hit 0.0% —
2219 VK055_4057 hypothetical protein AlphaFold DB model + ColabFold model – – No map N/A 0.632 No Hit 0.0% —
2220 VK055_3110 DNA-directed RNA polymerase, beta subunit rpoB Experimental + AlphaFold DB model + ColabFold model –
GO:0032549Binding to a ribonucleoside, a compound consisting of a purine or pyrimidine nitrogenous base linked to ribose. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0003899Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'. +14 total
No map 0.632 0.841 Hit 43.9% 5.70e-09
2221 VK055_2645 putative D-serine deaminase (D-serine dehydratase) protein AlphaFold DB model + ColabFold model –
GO:0016829Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring.
Mapped 2 0.632 0.147 No Hit 0.0% —
2222 VK055_1960 aminotransferase class-III family protein AlphaFold DB model + ColabFold model –
GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0008483Catalysis of the transfer of an amino group to an acceptor, usually a 2-oxo acid. GO:0030170Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. +14 total
No map 0.632 0.852 Hit 37.5% 3.75e-06
2223 VK055_0869 hypothetical protein AlphaFold DB model + ColabFold model – – No map N/A 0.632 No Hit 0.0% —
2224 VK055_0656 cation diffusion facilitator transporter family protein AlphaFold DB model + ColabFold model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0006812The directed movement of a monoatomic cation, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Monatomic cations (also called simple cations) are positively charged ions consisting of exactly one atom. GO:0008324Enables the transfer of cation from one side of a membrane to the other. +36 total
No map 0.632 0.837 Hit 22.9% 1.32e-12
2225 VK055_3256 LTXXQ motif family protein AlphaFold DB model + ColabFold model –
GO:0042597The region between the inner (cytoplasmic) and outer membrane (Gram-negative Bacteria) or cytoplasmic membrane and cell wall (Fungi and Gram-positive Bacteria). GO:0030288The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin peptidoglycan layer (PGL), also referred to as a thin cell wall. GO:0051082Binding to an unfolded protein.
No map N/A 0.631 No Hit 0.0% —
Page of 204 · 5081 total proteins