Proteins

Genome: KpATCC43816

Description: Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome

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# Protein Description Gene Structure EC GO Metabolism Druggability (P2Rank) P2RANK ligandability score for the best pocket in the experimental structure (0–1). Higher values indicate higher predicted ligandability. Available only for genomes analyzed with the curated pipeline. Druggability (FPocket) FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
2251 VK055_4437 periplasmic binding and sugar binding domain of LacI family protein AlphaFold DB model + ColabFold model –
GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. +14 total
No map 0.623 0.248 No Hit 0.0% —
2252 VK055_4417 marR family protein AlphaFold DB model + ColabFold model –
GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
No map N/A 0.623 No Hit 0.0% —
2253 VK055_4292 hypothetical protein AlphaFold DB model + ColabFold model – – No map N/A 0.623 No Hit 0.0% —
2254 VK055_4237 phage integrase family protein AlphaFold DB model + ColabFold model –
GO:0015074The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0006310Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Interchromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction.
No map 0.623 0.589 No Hit 0.0% —
2255 VK055_1508 integral membrane, PqiA family protein AlphaFold DB model + ColabFold model –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
No map 0.623 0.988 No Hit 0.0% —
2256 VK055_0199 type VI secretion system protein DUF879 impG2 AlphaFold DB model + ColabFold model – – No map 0.623 0.671 No Hit 0.0% —
2257 VK055_0142 hypothetical protein AlphaFold DB model + ColabFold model – – No map N/A 0.623 No Hit 0.0% —
2258 VK055_4550 transcriptional regulator family protein ColabFold model – – No map 0.622 0.81 No Hit 0.0% —
2259 VK055_1974 bacterial extracellular solute-binding, 5 Middlefamily protein AlphaFold DB model + ColabFold model –
GO:0043190A complex for the transport of metabolites into and out of the cell, typically comprised of four domains; two membrane-associated domains and two ATP-binding domains at the intracellular face of the membrane, that form a central pore through the plasma membrane. Each of the four core domains may be encoded as a separate polypeptide or the domains can be fused in any one of a number of ways into multidomain polypeptides. In Bacteria and Archaebacteria, ABC transporters also include substrate binding proteins to bind substrate external to the cytoplasm and deliver it to the transporter. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. GO:0030288The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin peptidoglycan layer (PGL), also referred to as a thin cell wall. +25 total
No map 0.622 0.918 No Hit 0.0% —
2260 VK055_0796 bacterial regulatory helix-turn-helix, lysR family protein AlphaFold DB model + ColabFold model –
GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. +14 total
No map 0.622 0.749 No Hit 0.0% —
2261 VK055_4391 phosphopyruvate hydratase eno AlphaFold DB model + ColabFold model
4.2.1.11
GO:0000015A multimeric enzyme complex, usually a dimer or an octamer, that catalyzes the conversion of 2-phospho-D-glycerate to phosphoenolpyruvate and water. GO:0000287Binding to a magnesium (Mg) ion. GO:0006096The chemical reactions and pathways resulting in the breakdown of a carbohydrate into pyruvate, with the concomitant production of a small amount of ATP and the reduction of NAD(P) to NAD(P)H. Glycolysis begins with the metabolism of a carbohydrate to generate products that can enter the pathway and ends with the production of pyruvate. Pyruvate may be converted to acetyl-coenzyme A, ethanol, lactate, or other small molecules. +36 total
Mapped 1 0.621 0.651 Hit 61.6% 4.81e-49
2262 VK055_4119 putative short-chain dehydrogenase AlphaFold DB model + ColabFold model – – No map 0.621 0.27 Hit 39.1% 2.50e-07
2263 VK055_3371 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.621 0.634 No Hit 0.0% —
2264 VK055_2553 signal peptidase II lspA AlphaFold DB model + ColabFold model
3.4.23.36
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0004190Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which a water molecule bound by the side chains of aspartic residues at the active center acts as a nucleophile. GO:0006508The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds. +14 total
No map 0.621 0.979 No Hit 0.0% —
2265 VK055_2089 hypothetical protein AlphaFold DB model + ColabFold model – – No map N/A 0.621 No Hit 0.0% —
2266 VK055_5055 hypothetical protein AlphaFold DB model + ColabFold model – – No map N/A 0.62 No Hit 0.0% —
2267 VK055_2860 bacterial regulatory helix-turn-helix, AraC family protein AlphaFold DB model + ColabFold model –
GO:0043565Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
No map 0.620 0.267 No Hit 0.0% —
2268 VK055_1993 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.620 0.975 No Hit 0.0% —
2269 VK055_1106 type VI secretion system protein impC1 AlphaFold DB model + ColabFold model – – No map N/A 0.62 No Hit 0.0% —
2270 VK055_1026 ATP-dependent helicase HrpA hrpA AlphaFold DB model + ColabFold model
3.6.4.13
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0003676Binding to a nucleic acid. GO:0003724Unwinding of an RNA helix, driven by ATP hydrolysis. +47 total
No map 0.620 0.393 Hit 51.2% 1.18e-07
2271 VK055_4853 2-succinyl-5-enolpyruvyl-6-hydroxy-3- cyclohexene-1-carboxylic-acid synthase menD AlphaFold DB model + ColabFold model
2.2.1.9
GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0030976Binding to thiamine pyrophosphate, the diphosphoric ester of thiamine. Acts as a coenzyme of several (de)carboxylases, transketolases, and alpha-oxoacid dehydrogenases. GO:0070204Catalysis of the reaction: 2-oxoglutarate + H+ + isochorismate = 5-enolpyruvoyl-6-hydroxy-2-succinyl-cyclohex-3-ene-1-carboxylate + CO2. +36 total
Chokepoint 1 0.619 0.729 No Hit 0.0% —
2272 VK055_4786 mlaA Experimental + ColabFold model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0120010The transport of phospholipids between membranes in which a phospholipid molecule is transported through an aqueous phase from the outer leaflet of a donor membrane to the outer leaflet of an acceptor membrane.
No map 0.619 0.936 No Hit 0.0% —
2273 VK055_4003 urease, alpha subunit ureC Experimental + ColabFold model
3.5.1.5
GO:0016810Catalysis of the hydrolysis of any carbon-nitrogen bond, C-N, with the exception of peptide bonds. GO:0009039Catalysis of the reaction: urea + 2 H2O + H+ = hydrogencarbonate + 2 NH4+. GO:0016787Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. +47 total
Mapped 2 0.619 0.672 No Hit 0.0% —
2274 VK055_1042 phenylacetic acid degradation protein paaN paaN AlphaFold DB model + ColabFold model –
GO:0016620Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces NAD or NADP. GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.
No map 0.619 0.703 Hit 29.3% 6.30e-06
2275 VK055_0984 hypothetical protein AlphaFold DB model + ColabFold model
1.5.1.3 1.5.1.50
GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. GO:0004146Catalysis of the reaction: 5,6,7,8-tetrahydrofolate + NADP+ = 7,8-dihydrofolate + NADPH + H+. GO:0006730The chemical reactions and pathways involving the transfer of one-carbon units in various oxidation states.
No map 0.619 0.283 Hit 26.0% 1.95e-09
Page of 204 · 5081 total proteins