Proteins

Genome: KpATCC43816

Description: Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome

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# Protein Description Gene Structure EC GO Metabolism Druggability (P2Rank) P2RANK ligandability score for the best pocket in the experimental structure (0–1). Higher values indicate higher predicted ligandability. Available only for genomes analyzed with the curated pipeline. Druggability (FPocket) FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
2151 VK055_2988 proton/sodium-glutamate symport protein gltT AlphaFold DB model + ColabFold model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0015293Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported together in the same direction in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. GO:0006835The directed movement of dicarboxylic acids into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. +25 total
No map 0.653 0.88 Hit 44.2% 5.54e-08
2152 VK055_4547 xylose isomerase-like TIM barrel family protein AlphaFold DB model + ColabFold model –
GO:0004519Catalysis of the cleavage of ester linkages within nucleic acids by creating internal breaks.
No map 0.652 0.762 No Hit 0.0% —
2153 VK055_2946 bacterial regulatory, luxR family protein AlphaFold DB model + ColabFold model –
GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
No map 0.652 0.983 No Hit 0.0% —
2154 VK055_2037 D-fructose-responsive transcription factor family protein AlphaFold DB model + ColabFold model –
GO:0009750Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a fructose stimulus. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
No map 0.652 0.935 No Hit 0.0% —
2155 VK055_4196 ammonium Transporter family protein ColabFold model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0072488The process in which ammonium is transported across a membrane. Ammonium is the cation NH4+. GO:0008519Enables the energy-independent facilitated diffusion of ammonium through a transmembrane aqueous pore or channel.
No map 0.651 0.435 No Hit 0.0% —
2156 VK055_3955 helix-turn-helix family protein AlphaFold DB model + ColabFold model –
GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
No map 0.651 0.323 No Hit 0.0% —
2157 VK055_3665 polymer-forming cytoskeletal family protein AlphaFold DB model + ColabFold model – – No map N/A 0.651 No Hit 0.0% —
2158 VK055_0567 helix-turn-helix family protein AlphaFold DB model + ColabFold model –
GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
No map 0.651 0.13 No Hit 0.0% —
2159 VK055_4166 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.650 0.733 No Hit 0.0% —
2160 VK055_3924 putative glycosylase AlphaFold DB model + ColabFold model –
GO:0005515Binding to a protein. GO:0004553Catalysis of the hydrolysis of any O-glycosyl bond. GO:0042597The region between the inner (cytoplasmic) and outer membrane (Gram-negative Bacteria) or cytoplasmic membrane and cell wall (Fungi and Gram-positive Bacteria). +47 total
No map 0.650 0.096 No Hit 0.0% —
2161 VK055_3471 DNA-directed RNA polymerase, omega subunit rpoZ AlphaFold DB model + ColabFold model
2.7.7.6
GO:0003899Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0006351The synthesis of an RNA transcript from a DNA template. +14 total
No map N/A 0.65 No Hit 0.0% —
2162 VK055_2964 phnA family protein AlphaFold DB model + ColabFold model – – No map N/A 0.65 No Hit 0.0% —
2163 VK055_0929 hypothetical protein AlphaFold DB model + ColabFold model – – No map N/A 0.65 No Hit 0.0% —
2164 VK055_4475 glucitol operon activator family protein AlphaFold DB model + ColabFold model – – No map N/A 0.649 No Hit 0.0% —
2165 VK055_3163 DNA helicase II uvrD AlphaFold DB model + ColabFold model
5.6.2.4
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0006268OBSOLETE. The process in which interchain hydrogen bonds between two strands of DNA are broken or 'melted', generating unpaired template strands for DNA replication. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). +1013 total
No map 0.649 0.038 No Hit 0.0% —
2166 VK055_3061 phosphoglucose isomerase family protein AlphaFold DB model + ColabFold model
5.3.1.9
GO:0004347Catalysis of the reaction: alpha-D-glucose 6-phosphate = beta-D-fructose 6-phosphate. GO:0006094The formation of glucose from noncarbohydrate precursors, such as pyruvate, amino acids and glycerol. GO:0097367Binding to a carbohydrate derivative. +58 total
No map 0.648 0.764 Hit 70.2% 0.00e+00
2167 VK055_1624 hypothetical protein AlphaFold DB model + ColabFold model – – No map N/A 0.648 No Hit 0.0% —
2168 VK055_0917 hypothetical protein AlphaFold DB model + ColabFold model –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
No map 0.648 0.464 No Hit 0.0% —
2169 VK055_3139 hypothetical protein AlphaFold DB model + ColabFold model – – No map N/A 0.647 No Hit 0.0% —
2170 VK055_2415 type II secretion system (T2SS), K family protein AlphaFold DB model + ColabFold model –
GO:0009306The controlled release of proteins from a cell. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
No map 0.647 0.921 No Hit 0.0% —
2171 VK055_0650 hypothetical protein AlphaFold DB model + ColabFold model – – No map N/A 0.647 No Hit 0.0% —
2172 VK055_5050 translation elongation factor G fusA2 AlphaFold DB model + ColabFold model –
GO:0003746Functions in chain elongation during polypeptide synthesis at the ribosome. GO:0005525Binding to GTP, guanosine triphosphate. GO:0006414The successive addition of amino acid residues to a nascent polypeptide chain during protein biosynthesis. +47 total
No map 0.646 0.557 Hit 60.0% 2.29e-14
2173 VK055_2626 putative glucosamine-fructose-6-phosphate aminotransferase AlphaFold DB model + ColabFold model –
GO:0097367Binding to a carbohydrate derivative. GO:1901135The chemical reactions and pathways involving carbohydrate derivative. GO:0004360Catalysis of the reaction: D-fructose 6-phosphate + L-glutamine = D-glucosamine 6-phosphate + L-glutamate. +36 total
Mapped 2 0.646 0.303 Hit 22.7% 9.17e-10
2174 VK055_2196 preprotein translocase, YajC subunit yajC AlphaFold DB model + ColabFold model –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0015031The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
No map N/A 0.646 No Hit 0.0% —
2175 VK055_0202 gene 25-like lysozyme family protein AlphaFold DB model + ColabFold model – – No map N/A 0.646 No Hit 0.0% —
Page of 204 · 5081 total proteins