Proteins

Genome: KpATCC43816

Description: Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome

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5081 proteins

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# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
201 VK055_0415 3-oxoacid CoA-transferase, A subunit AlphaFold + ColabFold –
GO:0008410Catalysis of the transfer of a coenzyme A (CoA) group from one compound (donor) to another (acceptor).
0.676 Hit 60.0% 8.31e-33
202 VK055_3679 glpD AlphaFold + ColabFold
1.1.5.3
GO:0009331An enzyme complex that catalyzes the oxidation of sn-glycerol 3-phosphate to dihydroxyacetone phosphate, with concurrent reduction of flavin adenine dinucleotide (FAD) to FADH2. In E. coli, the complex is either a GlpA-GlpB-GlpC heterotrimer that functions in anaerobic conditions, or a GlpD homodimer that functions in aerobic conditions. GO:0006072The chemical reactions and pathways involving glycerol-3-phosphate, a phosphoric monoester of glycerol. GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. +36 total
0.565 Hit 30.6% 1.05e-32
203 VK055_2595 nucleoside transporter, NupC family protein AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:1901642The directed movement of nucleoside across a membrane. GO:0005337Enables the transfer of a nucleoside, a nucleobase linked to either beta-D-ribofuranose (ribonucleoside) or 2-deoxy-beta-D-ribofuranose, (a deoxyribonucleotide) from one side of a membrane to the other. +25 total
0.769 Hit 39.0% 1.24e-32
204 VK055_4038 1-acylglycerol-3-phosphate O-acyltransferases domain protein AlphaFold + ColabFold
2.3.1.51
GO:0003841Catalysis of the reaction: acyl-CoA + 1-acyl-sn-glycerol-3-phosphate = CoA + 1,2-diacyl-sn-glycerol-3-phosphate. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0008654The chemical reactions and pathways resulting in the formation of a phospholipid, a lipid containing phosphoric acid as a mono- or diester. +47 total
0.901 Hit 29.9% 1.26e-32
205 VK055_4126 erythrose-4-phosphate dehydrogenase epd AlphaFold + ColabFold
1.2.1.72
GO:0016620Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces NAD or NADP. GO:0051287Binding to nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD+, or the reduced form, NADH. GO:0042823The chemical reactions and pathways resulting in the formation of pyridoxal phosphate, pyridoxal phosphorylated at the hydroxymethyl group of C-5, the active form of vitamin B6. +36 total
0.7 Hit 39.0% 1.80e-32
206 VK055_4839 nuoC AlphaFold + ColabFold
7.1.1.-
GO:0050136Catalysis of the reaction: NADH + H+ + a quinone = NAD+ + a quinol. GO:0048038Binding to a quinone, any member of a class of diketones derivable from aromatic compounds by conversion of two CH groups into CO groups with any necessary rearrangement of double bonds. GO:0008137Catalysis of the reaction: NADH + ubiquinone + 5 H+(in) = NAD+ + ubiquinol + 4 H+(out). +58 total
0.836 Hit 44.5% 1.93e-32
207 VK055_0795 NAD-dependent glycerol-3-phosphate dehydrogenasefamily protein AlphaFold + ColabFold –
GO:0050661Binding to nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP+, or the reduced form, NADPH. GO:0051287Binding to nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD+, or the reduced form, NADH. GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. +14 total
0.917 Hit 29.0% 2.21e-32
208 VK055_0069 DNA-binding regulatory, YebC/PmpR family protein AlphaFold + ColabFold –
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
0.9 Hit 31.2% 2.73e-32
209 VK055_1709 heme ABC exporter, ATP-binding protein CcmA ccmA4 AlphaFold + ColabFold –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.
0.13 Hit 36.9% 2.73e-32
210 VK055_1043 primary amine oxidase maoA AlphaFold + ColabFold
1.4.3.-
GO:0005507Binding to a copper (Cu) ion. GO:0008131Catalysis of the reaction: a primary methyl amine + H2O + O2 = an aldehyde + H2O2 + NH4+. GO:0048038Binding to a quinone, any member of a class of diketones derivable from aromatic compounds by conversion of two CH groups into CO groups with any necessary rearrangement of double bonds. +36 total
0.985 Hit 28.1% 3.19e-32
211 VK055_2280 proB proB AlphaFold + ColabFold
2.7.2.11
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016301Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. GO:0006561OBSOLETE. The chemical reactions and pathways resulting in the formation of proline (pyrrolidine-2-carboxylic acid), a chiral, cyclic, nonessential alpha-amino acid found in peptide linkage in proteins. +58 total
0.29 Hit 33.4% 3.33e-32
212 VK055_3509 2-amino-3-ketobutyrate coenzyme A ligase kbl AlphaFold + ColabFold
2.3.1.29
GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0006567The chemical reactions and pathways resulting in the breakdown of L-threonine. GO:0016740Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. +69 total
0.193 Hit 56.4% 9.19e-32
213 VK055_1667 molybdopterin biosynthesis AlphaFold + ColabFold
2.10.1.1
GO:0032324The chemical reactions and pathways resulting in the formation of the molybdopterin cofactor (Moco), essential for the catalytic activity of some enzymes, e.g. sulfite oxidase, xanthine dehydrogenase, and aldehyde oxidase. The cofactor consists of a mononuclear molybdenum (Mo-molybdopterin) or tungsten ion (W-molybdopterin) coordinated by one or two molybdopterin ligands. GO:0006777The chemical reactions and pathways resulting in the formation of the Mo-molybdopterin cofactor, essential for the catalytic activity of some enzymes. The cofactor consists of a mononuclear molybdenum (Mo) ion coordinated by one or two molybdopterin ligands. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. +25 total
0.787 Hit 43.4% 9.54e-32
214 VK055_1321 tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase trmU AlphaFold + ColabFold –
GO:0016783Catalysis of the transfer of sulfur atoms from one compound (donor) to another (acceptor). GO:0008033The process in which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group. GO:0016740Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2.
0.22 Hit 54.6% 1.05e-31
215 VK055_2839 fructose-1-6-bisphosphatase family protein AlphaFold + ColabFold
3.1.3.11
GO:0042578Catalysis of the reaction: RPO-R' + H2O = RPOOH + R'H. This reaction is the hydrolysis of any phosphoric ester bond, any ester formed from orthophosphoric acid, O=P(OH)3. GO:0016791Catalysis of the hydrolysis of a phosphoric monoester, releasing a phosphate. GO:0005975The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. +811 total
0.227 Hit 48.9% 1.20e-31
216 VK055_3483 ABC transporter family protein AlphaFold + ColabFold –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.
0.707 Hit 35.8% 1.33e-31
217 VK055_3640 signal recognition particle-docking protein FtsY ftsY AlphaFold + ColabFold
3.6.5.4
GO:0005525Binding to GTP, guanosine triphosphate. GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. GO:0006614The targeting of proteins to a membrane that occurs during translation and is dependent upon two key components, the signal-recognition particle (SRP) and the SRP receptor. SRP is a cytosolic particle that transiently binds to the endoplasmic reticulum (ER) signal sequence in a nascent protein, to the large ribosomal unit, and to the SRP receptor in the ER membrane. +58 total
0.076 Hit 35.0% 1.41e-31
218 VK055_0172 putative N-acetyltransferase AlphaFold + ColabFold –
GO:0016747Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). GO:0008080Catalysis of the transfer of an acetyl group to a nitrogen atom on the acceptor molecule.
0.402 Hit 37.7% 1.78e-31
219 VK055_4580 SMP-30/Gluconolaconase/LRE-like region family protein AlphaFold + ColabFold –
GO:0005509Binding to a calcium ion (Ca2+). GO:0004341Catalysis of the reaction: D-glucono-1,5-lactone + H2O = D-gluconate. GO:0019853The chemical reactions and pathways resulting in the formation of L-ascorbic acid; L-ascorbic acid ionizes to give L-ascorbate, (2R)-2-[(1S)-1,2-dihydroxyethyl]-4-hydroxy-5-oxo-2,5-dihydrofuran-3-olate, which is required as a cofactor in the oxidation of prolyl residues to hydroxyprolyl, and other reactions.
0.931 Hit 30.4% 1.91e-31
220 VK055_0206 50S ribosome-binding GTPase family protein AlphaFold + ColabFold –
GO:0005525Binding to GTP, guanosine triphosphate. GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. +36 total
0.495 Hit 59.8% 2.32e-31
221 VK055_1396 rhodanese-like domain protein AlphaFold + ColabFold
1.14.-.-
GO:0016705Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor. GO:0006400The covalent alteration of one or more nucleotides within a tRNA molecule to produce a tRNA molecule with a sequence that differs from that coded genetically.
0.87 Hit 31.2% 4.40e-31
222 VK055_4030 DNA topoisomerase IV, B subunit parE AlphaFold + ColabFold –
GO:0003918Catalysis of a DNA topological transformation by transiently cleaving a pair of complementary DNA strands to form a gate through which a second double-stranded DNA segment is passed, after which the severed strands in the first DNA segment are rejoined, driven by ATP hydrolysis. The enzyme changes the linking number in multiples of 2. GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0006265The process in which a transformation is induced in the topological structure of a double-stranded DNA helix, resulting in a change in linking number. +25 total
0.795 Hit 24.7% 4.83e-31
223 VK055_2911 EF-P lysine aminoacylase GenX AlphaFold + ColabFold
6.3.2.-
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0004812Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of diphosphate and AMP. GO:0000166Binding to a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose. +710 total
0.207 Hit 27.8% 6.40e-31
224 VK055_3859 isoprenoid biosynthesis protein with amidotransferase-like domain yhbL AlphaFold + ColabFold –
GO:0016829Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring.
0.269 Hit 54.8% 6.52e-31
225 VK055_4133 ribose 5-phosphate isomerase A rpiA AlphaFold + ColabFold
5.3.1.6
GO:0004751Catalysis of the reaction: aldehydo-D-ribose 5-phosphate = D-ribulose 5-phosphate. GO:0009052The branch of the pentose-phosphate shunt which does not involve oxidation reactions. It comprises a series of sugar phosphate interconversions, starting with ribulose 5-P and producing fructose 6-P and glyceraldehyde 3-P. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. +14 total
0.176 Hit 37.1% 8.58e-31
Page of 204 · 5081 total proteins