Proteins

Genome: KpATCC43816

Description: Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome

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5081 proteins

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Rows
# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
1 VK055_0908 hypothetical protein AlphaFold + ColabFold – – No pocket No Hit 0.0% —
2 VK055_0998 hypothetical protein ColabFold – – No pocket No Hit 0.0% —
3 VK055_1447 hypothetical protein AlphaFold + ColabFold – – No pocket No Hit 0.0% —
4 VK055_1932 mbtH-like family protein AlphaFold + ColabFold –
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0019290The chemical reactions and pathways resulting in the formation of siderophores, low molecular weight Fe(III)-chelating substances made by aerobic or facultatively anaerobic bacteria, especially when growing under iron deficient conditions. The complexes of Fe(3+)-siderophores have very high stability constants and are taken up by specific transport systems by microorganisms; the subsequent release of iron requires enzymatic action.
No pocket No Hit 0.0% —
5 VK055_2485 cell division protein FtsL ftsL AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0051301The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells. GO:0032153The eventual plane of cell division (also known as cell cleavage or cytokinesis) in a dividing cell. In Eukaryotes, the cleavage apparatus, composed of septin structures and the actomyosin contractile ring, forms along this plane, and the mitotic, or meiotic, spindle is aligned perpendicular to the division plane. In bacteria, the cell division site is generally located at mid-cell and is the site at which the cytoskeletal structure, the Z-ring, assembles. +25 total
No pocket No Hit 0.0% —
6 VK055_3130 hypothetical protein ColabFold – – No pocket No Hit 0.0% —
7 VK055_4351 putative lipoprotein Experimental + ColabFold – – No pocket No Hit 0.0% —
8 VK055_0225 hypothetical protein AlphaFold + ColabFold – – 0.001 No Hit 0.0% —
9 VK055_0872 marB family protein marB AlphaFold + ColabFold – – 0.001 No Hit 0.0% —
10 VK055_1164 hypothetical protein AlphaFold + ColabFold – – 0.001 No Hit 0.0% —
11 VK055_1354 protein involved in stress resistance and biofilm formation ycfR AlphaFold + ColabFold – – 0.001 No Hit 0.0% —
12 VK055_1556 hypothetical protein AlphaFold + ColabFold – – 0.001 No Hit 0.0% —
13 VK055_0999 ydfZ family protein AlphaFold + ColabFold – – 0.002 No Hit 0.0% —
14 VK055_1288 hypothetical protein AlphaFold + ColabFold – – 0.002 No Hit 0.0% —
15 VK055_4929 hypothetical protein ColabFold – – 0.002 No Hit 0.0% —
16 VK055_1166 hypothetical protein AlphaFold + ColabFold – – 0.003 No Hit 0.0% —
17 VK055_1499 hypothetical protein ColabFold – – 0.003 No Hit 0.0% —
18 VK055_3025 ssDNA-binding protein ssb Experimental + ColabFold –
GO:0003697Binding to single-stranded DNA. GO:0006260The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by the origin recognition complex, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA.
0.003 Hit 38.9% 3.24e-16
19 VK055_3279 hypothetical protein AlphaFold + ColabFold – – 0.003 No Hit 0.0% —
20 VK055_4749 HPr ptsH AlphaFold + ColabFold –
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0009401The uptake and phosphorylation of specific carbohydrates from the extracellular environment; uptake and phosphorylation are coupled, making the PTS a link between the uptake and metabolism of sugars; phosphoenolpyruvate is the original phosphate donor; phosphoenolpyruvate passes the phosphate via a signal transduction pathway, to enzyme 1 (E1), which in turn passes it on to the histidine protein, HPr; the next step in the system involves sugar-specific membrane-bound complex, enzyme 2 (EII), which transports the sugar into the cell; it includes the sugar permease, which catalyzes the transport reactions; EII is usually divided into three different domains, EIIA, EIIB, and EIIC.
0.003 No Hit 0.0% —
21 VK055_0158 putative nitrilotriacetate monooxygenase AlphaFold + ColabFold – – 0.004 No Hit 0.0% —
22 VK055_1748 biofilm development YmgB/AriR family protein AlphaFold + ColabFold –
GO:0071468Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pH stimulus with pH < 7. pH is a measure of the acidity or basicity of an aqueous solution.
0.004 No Hit 0.0% —
23 VK055_2695 hypothetical protein ColabFold – – 0.004 No Hit 0.0% —
24 VK055_5160 endodeoxyribonuclease RusA family protein ColabFold –
GO:0006281The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. GO:0000287Binding to a magnesium (Mg) ion. GO:0006310Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Interchromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction.
0.004 No Hit 0.0% —
25 VK055_0226 dsrE/DsrF-like family protein AlphaFold + ColabFold –
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
0.005 No Hit 0.0% —
Page of 204 · 5081 total proteins