Proteins

Genome: KpKP13

Description: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence

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4 proteins

Scoring formula None

Sorted by Druggability (descending)

Applied filters EC Number: 1.3.1.9

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EC Number: 1.3.1.9 ×
# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
1 KP13_04773 Putative quinone oxidoreductase AlphaFold + ColabFold
1.3.1.95 1.3.1.84 1.6.5.-
GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. GO:0043958Catalysis of the reaction: propanoyl-CoA + NAD+ = acryloyl-CoA + H+ + NADH. GO:0043957Catalysis of the reaction: acryloyl-CoA + NADPH + H+ = propionyl-CoA + NADP+.
0.832 Hit 29.1% 1.23e-07
2 KP13_05433 Enoyl-[acyl-carrier-protein] reductase [NADH] fabI Experimental + ColabFold
1.3.1.9
GO:0004318Catalysis of the reaction: a 2,3-saturated acyl-[ACP] + NAD+ = a (2E)-enoyl-[ACP] + H+ + NADH. GO:0006633The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. GO:0009102The chemical reactions and pathways resulting in the formation of biotin, cis-tetrahydro-2-oxothieno(3,4-d)imidazoline-4-valeric acid.
0.532 Hit 30.9% 2.07e-07
3 KP13_08655 tRNA-dihydrouridine synthase A dusA AlphaFold + ColabFold
1.3.1.91
GO:0017150Catalysis of the reaction: a 5,6-dihydrouridine in tRNA + NAD(P)+ = a uridine in tRNA + H+ + NAD(P)H. GO:0002943The process whereby a uridine in a transfer RNA is converted to dihydrouridine. GO:0008033The process in which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group. +58 total
0.416 Hit 32.1% 5.81e-08
4 KP13_01348 UDP-N-acetylenolpyruvoylglucosamine reductase murB AlphaFold + ColabFold
1.3.1.98
GO:0071949Binding to the oxidized form, FAD, of flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. GO:0050660Binding to FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2. GO:0008762Catalysis of the reaction: UDP-N-acetylmuramate + NADP+ = UDP-N-acetyl-3-O-(1-carboxyvinyl)-D-glucosamine + NADPH + H+. +58 total
0.027 No Hit 0.0% —
Page 1 of 1 · 4 total proteins