Proteins

Genome: KpKP13

Description: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence

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5842 proteins

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# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
476 KP13_05362 Putative tartrate transporter ttuB AlphaFold + ColabFold –
GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
0.999 Hit 22.4% 2.74e-16
477 KP13_02901 Dihydrolipoamide dehydrogenase acoD AlphaFold + ColabFold
1.8.1.4
GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. GO:0050660Binding to FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2. GO:0016668Catalysis of an oxidation-reduction (redox) reaction in which a sulfur-containing group acts as a hydrogen or electron donor and reduces NAD or NADP. +47 total
0.926 Hit 63.2% 2.81e-16
478 KP13_03398 Enterobactin synthase component E bifunctional protein entE AlphaFold + ColabFold –
GO:0008668Catalysis of the reaction: 2,3-dihydroxybenzoate + ATP + holo-[ACP] = 2,3-dihydroxybenzoyl-[ACP] + AMP + diphosphate. GO:0019290The chemical reactions and pathways resulting in the formation of siderophores, low molecular weight Fe(III)-chelating substances made by aerobic or facultatively anaerobic bacteria, especially when growing under iron deficient conditions. The complexes of Fe(3+)-siderophores have very high stability constants and are taken up by specific transport systems by microorganisms; the subsequent release of iron requires enzymatic action.
0.554 Hit 34.0% 2.81e-16
479 KP13_02514 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase ispD AlphaFold + ColabFold
2.7.7.60
GO:0008299The chemical reactions and pathways resulting in the formation of an isoprenoid compound, isoprene (2-methylbuta-1,3-diene) or compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues. GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0070567Catalysis of the transfer of a cytidylyl group to an acceptor. +25 total
0.114 Hit 27.0% 3.14e-16
480 KP13_00396 Single-stranded DNA-binding protein ssb Experimental + ColabFold –
GO:0006260The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by the origin recognition complex, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA. GO:0003697Binding to single-stranded DNA.
0.003 Hit 38.9% 3.24e-16
481 KP13_02101 Penicillin-binding protein ampH ampH AlphaFold + ColabFold –
GO:0004180Catalysis of the hydrolysis of a single C-terminal amino acid residue from a polypeptide chain.
0.727 Hit 30.3% 3.80e-16
482 KP13_02429 Protein grpE grpE AlphaFold + ColabFold –
GO:0000774Binds to and stimulates the hydrolysis and exchange of adenyl nucleotides by other proteins. GO:0051087Binding to a chaperone protein, a class of proteins that bind to nascent or unfolded polypeptides and ensure correct folding or transport. GO:0042803Binding to an identical protein to form a homodimer. +36 total
0.579 Hit 35.8% 4.16e-16
483 KP13_05361 putative tartrate dehydrogenase/decarboxylase ttuC' ttuC AlphaFold + ColabFold –
GO:0051287Binding to nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD+, or the reduced form, NADH. GO:0000287Binding to a magnesium (Mg) ion. GO:0016616Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP.
0.626 Hit 37.2% 4.32e-16
484 KP13_05170 Endonuclease III nth AlphaFold + ColabFold
4.2.99.18
GO:0051539Binding to a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands. GO:0003906Catalysis of the cleavage of the C-O-P bond in the AP site created when DNA glycosylase removes a damaged base, involved in the DNA base excision repair pathway (BER). GO:0006284In base excision repair, an altered base is removed by a DNA glycosylase enzyme, followed by excision of the resulting sugar phosphate. The small gap left in the DNA helix is filled in by the sequential action of DNA polymerase and DNA ligase. +710 total
0.425 Hit 35.5% 4.82e-16
485 KP13_02492 4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase, HpaG1subunit AlphaFold + ColabFold –
GO:0018800Catalysis of the reaction: 5-oxopent-3-ene-1,2,5-tricarboxylate = 2-oxohept-3-enedioate + CO2. GO:0008704Catalysis of the reaction: 5-carboxymethyl-2-hydroxymuconate = 5-carboxy-2-oxohept-3-enedioate. GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. +14 total
0.881 Hit 30.5% 4.86e-16
486 KP13_04600 Putative acyl-CoA dehydrogenase AlphaFold + ColabFold –
GO:0016627Catalysis of an oxidation-reduction (redox) reaction in which a CH-CH group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. GO:0050660Binding to FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2.
0.817 Hit 25.2% 4.86e-16
487 KP13_04445 Aryl-alcohol dehydrogenase AlphaFold + ColabFold –
GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. GO:0008270Binding to a zinc ion (Zn). GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. +25 total
0.894 Hit 49.4% 5.33e-16
488 KP13_02071 Proline-specific permease proY proY AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0006865The directed movement of amino acids, organic acids containing one or more amino substituents, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. +14 total
0.614 Hit 26.3% 5.48e-16
489 KP13_02428 cystathionine beta-synthase domain-containing protein Experimental + AlphaFold + ColabFold –
GO:0050660Binding to FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2.
0.957 Hit 25.9% 5.68e-16
490 KP13_31997 Molybdenum import ATP-binding protein ModC modC AlphaFold + ColabFold –
GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. GO:0015689The directed movement of molybdate (MoO4 2-) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Molybdate is the bivalent anion derived from molybdic acid. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. +36 total
0.205 Hit 35.8% 5.80e-16
491 KP13_03813 Beta-glucoside kinase bglK AlphaFold + ColabFold –
GO:0016301Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule.
0.425 Hit 26.3% 6.39e-16
492 KP13_02024 5'-nucleotidase AlphaFold + ColabFold –
GO:0008253Catalysis of the reaction: a 5'-ribonucleotide + H2O = a ribonucleoside + phosphate.
0.23 Hit 30.3% 6.95e-16
493 KP13_01878 Dihydrolipoyl dehydrogenase lpdA AlphaFold + ColabFold
1.8.1.4
GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. GO:0050660Binding to FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2. GO:0016668Catalysis of an oxidation-reduction (redox) reaction in which a sulfur-containing group acts as a hydrogen or electron donor and reduces NAD or NADP. +47 total
0.981 Hit 52.8% 7.04e-16
494 KP13_00486 Divalent-cation tolerance protein cutA cutA AlphaFold + ColabFold –
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0005507Binding to a copper (Cu) ion. GO:0010038Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a metal ion stimulus.
0.035 Hit 40.5% 8.45e-16
495 KP13_03414 putative ABC transporter AlphaFold + ColabFold
3.6.3.17
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
0.49 Hit 33.8% 8.57e-16
496 KP13_01957 Ribosomal RNA small subunit methyltransferase A rsmA AlphaFold + ColabFold
2.1.1.182
GO:0000154The covalent alteration of one or more nucleotides within an rRNA molecule to produce an rRNA molecule with a sequence that differs from that coded genetically. GO:0008649Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a nucleoside residue in an rRNA molecule. The methyl group can be transfered to the nucleobase or to the ribose group of the nucleoside. GO:0006364Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules. +47 total
0.952 Hit 32.7% 9.00e-16
497 KP13_31621 Lipopolysaccharide export system ATP-binding protein lptB lptB Experimental + AlphaFold + ColabFold –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0043190A complex for the transport of metabolites into and out of the cell, typically comprised of four domains; two membrane-associated domains and two ATP-binding domains at the intracellular face of the membrane, that form a central pore through the plasma membrane. Each of the four core domains may be encoded as a separate polypeptide or the domains can be fused in any one of a number of ways into multidomain polypeptides. In Bacteria and Archaebacteria, ABC transporters also include substrate binding proteins to bind substrate external to the cytoplasm and deliver it to the transporter. GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. +25 total
0.495 Hit 34.4% 1.03e-15
498 KP13_03445 putative transcriptional regulator, GntR family/aminotransferase, classes I and II AlphaFold + ColabFold –
GO:0030170Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0009058A cellular process consisting of the biochemical pathways by which a living organism synthesizes chemical substances. This typically represents the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. +47 total
0.557 Hit 27.0% 1.18e-15
499 KP13_31623 2,3-dihydroxybenzoic acid decarboxylase AlphaFold + ColabFold –
GO:0016831Catalysis of the nonhydrolytic addition or removal of a carboxyl group to or from a compound. GO:0016787Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. +14 total
0.556 Hit 25.1% 1.43e-15
500 KP13_01111 Ribosomal RNA large subunit methyltransferase E rlmE AlphaFold + ColabFold
2.1.1.166
GO:0001510Posttranscriptional addition of a methyl group to either a nucleotide or 2'-O ribose in a polyribonucleotide. Usually uses S-adenosylmethionine as a cofactor. GO:0008168Catalysis of the transfer of a methyl group to an acceptor molecule. GO:0006364Any process involved in the conversion of a primary ribosomal RNA (rRNA) transcript into one or more mature rRNA molecules. +47 total
0.115 Hit 40.5% 1.45e-15
Page of 234 · 5842 total proteins