Proteins

Genome: KpKP13

Description: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence

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5842 / 5842 proteins

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# Protein Description Gene Structure EC GO Metabolism Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
476 KP13_00768 50S ribosomal protein L15 rplO AlphaFold DB model + ColabFold model –
GO:0006412The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome. GO:0015934The larger of the two subunits of a ribosome. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). GO:0005840An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. +36 total
No map 0.304 No Hit 0.0% —
477 KP13_00769 Preprotein translocase subunit secY secY AlphaFold DB model + ColabFold model –
GO:0015031The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. +36 total
No map 0.924 No Hit 0.0% —
478 KP13_00772 30S ribosomal protein S4 rpsD AlphaFold DB model + ColabFold model –
GO:0015935The smaller of the two subunits of a ribosome. GO:0003735The action of a molecule that contributes to the structural integrity of the ribosome. GO:0003723Binding to an RNA molecule or a portion thereof. +36 total
No map 0.437 No Hit 0.0% —
479 KP13_00773 DNA-directed RNA polymerase subunit alpha rpoA AlphaFold DB model + ColabFold model
2.7.7.6
GO:0003899Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'. GO:0006351The synthesis of an RNA transcript from a DNA template. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). +36 total
No map 0.82 No Hit 0.0% —
480 KP13_00775 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.6 No Hit 0.0% —
481 KP13_00776 HTH-type transcriptional regulator zntR zntR AlphaFold DB model + ColabFold model –
GO:0008270Binding to a zinc ion (Zn). GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. +25 total
No map 0.344 No Hit 0.0% —
482 KP13_00777 Large-conductance mechanosensitive channel mscL AlphaFold DB model + ColabFold model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0034220A process in which a monoatomic ion is transported across a membrane. Monatomic ions (also called simple ions) are ions consisting of exactly one atom. GO:0008381Enables the transmembrane transfer of an monoatomic ion by a channel that opens in response to a mechanical stress. +14 total
No map 0.578 No Hit 0.0% —
483 KP13_00778 Trk system potassium uptake protein trkA trkA AlphaFold DB model + ColabFold model –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0015079Enables the transfer of potassium ions (K+) from one side of a membrane to the other. GO:0006813The directed movement of potassium ions (K+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. +14 total
No map 0.15 No Hit 0.0% —
484 KP13_00782 Protein smf smf AlphaFold DB model + ColabFold model –
GO:0009294The direct uptake and incorporation of exogenous genetic material (DNA or RNA) into a cell from its surroundings through the cell envelope.
No map 0.584 No Hit 0.0% —
485 KP13_00783 Protein smg smg AlphaFold DB model + ColabFold model – – No map 0.569 No Hit 0.0% —
486 KP13_00784 DNA topoisomerase, type IA, Zn finger domain-containing protein AlphaFold DB model + ColabFold model –
GO:0006265The process in which a transformation is induced in the topological structure of a double-stranded DNA helix, resulting in a change in linking number. GO:0003916Catalysis of the transient cleavage and passage of individual DNA strands or double helices through one another, resulting a topological transformation in double-stranded DNA. GO:0003917Catalysis of a DNA topological transformation by transiently cleaving one DNA strand at a time to allow passage of another strand; changes the linking number by +1 per catalytic cycle. +25 total
No map 0.767 No Hit 0.0% —
487 KP13_00786 Shikimate dehydrogenase aroE AlphaFold DB model + ColabFold model –
GO:0050661Binding to nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP+, or the reduced form, NADPH. GO:0004764Catalysis of the reaction: shikimate + NADP+ = 3-dehydroshikimate + NADPH + H+. GO:0019632The chemical reactions and pathways involving shikimate, (3R,4S,5R)--3,4,5-trihydroxycyclohex-1-ene-1-carboxylate, the anion of shikimic acid. It is an important intermediate in the biosynthesis of aromatic amino acids.
No map 0.042 No Hit 0.0% —
488 KP13_00787 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.065 No Hit 0.0% —
489 KP13_00788 hypothetical protein AlphaFold DB model + ColabFold model –
GO:0016740Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2.
No map 0.281 No Hit 0.0% —
490 KP13_00789 hypothetical protein ColabFold model – – No map 0.226 No Hit 0.0% —
491 KP13_00790 hypothetical protein ColabFold model – – No map 0.431 No Hit 0.0% —
492 KP13_00792 hypothetical protein ColabFold model – – No map No pocket No Hit 0.0% —
493 KP13_00793 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.108 No Hit 0.0% —
494 KP13_00794 Alpha-ketoglutarate permease kgtP AlphaFold DB model + ColabFold model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.
No map 0.933 No Hit 0.0% —
495 KP13_00795 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.812 No Hit 0.0% —
496 KP13_00797 GNAT family acetyltransferase AlphaFold DB model + ColabFold model –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016747Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor).
No map 0.432 No Hit 0.0% —
497 KP13_00798 hypothetical protein AlphaFold DB model + ColabFold model
2.5.1.25
GO:0016432Catalysis of the reaction: a uridine in tRNA + S-adenosyl-L-methionine = a 3-[(3S)-3-amino-3-carboxypropyl]uridine in tRNA + S-methyl-5'-thioadenosine + H+. GO:0008033The process in which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group.
No map 0.334 No Hit 0.0% —
498 KP13_00802 Autonomous glycyl radical cofactor grcA AlphaFold DB model + ColabFold model –
GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0008861Catalysis of the reaction: acetyl-CoA + formate = CoA + pyruvate.
No map 0.079 No Hit 0.0% —
499 KP13_00804 tRNA (adenine-N(6)-)-methyltransferase AlphaFold DB model + ColabFold model –
GO:0016430OBSOLETE. Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing N6-methyladenine. GO:0003676Binding to a nucleic acid. GO:0032259The process in which a methyl group is covalently attached to a molecule. +14 total
No map 0.623 No Hit 0.0% —
500 KP13_00806 RNA polymerase sigma-E factor rpoE AlphaFold DB model + ColabFold model –
GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0016987Sigma factors act as the promoter specificity subunit of eubacterial and plant plastid multisubunit RNA polymerases, whose core subunit composition is often described as alpha(2)-beta-beta-prime. Although sigma does not bind DNA on its own, when combined with the core to form the holoenzyme, the sigma factor binds specifically to promoter elements. The sigma subunit is released once elongation begins. GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. +47 total
No map 0.939 No Hit 0.0% —
Page of 234 · 5842 total proteins