Proteins

Genome: KpKP13

Description: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence

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5192 proteins Structure: AlphaFold

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Structure: AlphaFold ×
# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
51 KP13_00956 3-demethylubiquinone-9 3-methyltransferase ubiG AlphaFold + ColabFold
2.1.1.222 2.1.1.64
GO:0008425Catalysis of the reaction: a 2-methoxy-6-all-trans-polyprenyl-1,4-benzoquinol + S-adenosyl-L-methionine = a 6-methoxy-3-methyl-2-all-trans-polyprenyl-1,4-benzoquinol + S-adenosyl-L-homocysteine + H+. GO:0006744The chemical reactions and pathways resulting in the formation of ubiquinone, a lipid-soluble electron-transporting coenzyme. GO:0102208Catalysis of the reaction: a 3-(all-trans-polyprenyl)benzene-1,2-diol + S-adenosyl-L-methionine = a 2-methoxy-6-(all-trans-polyprenyl)phenol + H+ + S-adenosyl-L-homocysteine. +36 total
0.997 Hit 33.1% 1.62e-46
52 KP13_00722 Fusaric acid resistance protein AlphaFold + ColabFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0016787Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc.
0.997 No Hit 0.0% —
53 KP13_31941 Lipid II flippase FtsW ftsW AlphaFold + ColabFold
2.4.99.28
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0009252The chemical reactions and pathways resulting in the formation of peptidoglycans, any of a class of glycoconjugates found in bacterial cell walls and consisting of long glycan strands of alternating residues of beta-(1,4) linked N-acetylglucosamine and N-acetylmuramic acid, cross-linked by short peptides. GO:0051301The process resulting in division and partitioning of components of a cell to form more cells; may or may not be accompanied by the physical separation of a cell into distinct, individually membrane-bounded daughter cells. +710 total
0.996 No Hit 0.0% —
54 KP13_05375 Ferric enterobactin receptor pfeA AlphaFold + ColabFold –
GO:0009279A lipid bilayer that forms the outermost membrane of the cell envelope; enriched in polysaccharide and protein; the outer leaflet of the membrane contains specific lipopolysaccharide structures. GO:0015891The directed movement of siderophores, low molecular weight Fe(III)-chelating substances, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. GO:0015343Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: siderophore-iron(out) + H+(out) = siderophore-iron(in) + H+(in). +14 total
0.996 No Hit 0.0% —
55 KP13_03324 Apolipoprotein N-acyltransferase lnt AlphaFold + ColabFold
2.3.1.269
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0016410Catalysis of the transfer of an acyl group to a nitrogen atom on the acceptor molecule. GO:0006807OBSOLETE. The chemical reactions and pathways involving organic or inorganic compounds that contain nitrogen. +25 total
0.996 No Hit 0.0% —
56 KP13_02505 Carbon starvation protein AlphaFold + ColabFold –
GO:0009267Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of nourishment. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
0.996 No Hit 0.0% —
57 KP13_02234 Putative nickel/cobalt efflux system AlphaFold + ColabFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0035444The directed movement of nickel (Ni) cations across a membrane by means of some agent such as a transporter or pore. GO:0015099Enables the transfer of nickel (Ni) cations from one side of a membrane to the other. +47 total
0.996 No Hit 0.0% —
58 KP13_02140 Outer membrane pore protein E phoE AlphaFold + ColabFold –
GO:0009279A lipid bilayer that forms the outermost membrane of the cell envelope; enriched in polysaccharide and protein; the outer leaflet of the membrane contains specific lipopolysaccharide structures. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0034220A process in which a monoatomic ion is transported across a membrane. Monatomic ions (also called simple ions) are ions consisting of exactly one atom. +25 total
0.996 No Hit 0.0% —
59 KP13_31943 Asparagine synthetase B glutamine-hydrolyzing asnB AlphaFold + ColabFold
6.3.5.4
GO:0004066Catalysis of the reaction: ATP + L-aspartate + L-glutamine = AMP + diphosphate + L-asparagine + L-glutamate. GO:0006529OBSOLETE. The chemical reactions and pathways resulting in the formation of asparagine, 2-amino-3-carbamoylpropanoic acid. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. +14 total
0.995 Hit 37.5% 1.28e-102
60 KP13_03272 Cytochrome d ubiquinol oxidase subunit 1 cydA AlphaFold + ColabFold –
GO:0019646A process in which a series of electron carriers operate together to transfer electrons from donors such as NADH and FADH2 to oxygen to generate a transmembrane electrochemical gradient. GO:0009055A molecular function representing the directed movement of electrons from one molecular entity to another, typically mediated by electron carriers or acceptors, resulting in the transfer of energy and/or the reduction-oxidation (redox) transformation of chemical species. This activity is fundamental to various biological processes, including cellular respiration and photosynthesis, as well as numerous enzymatic reactions involved in metabolic pathways. GO:0070069A protein complex in which at least one of the proteins is a cytochrome, i.e. a heme-containing protein involved in catalysis of redox reactions. +47 total
0.995 No Hit 0.0% —
61 KP13_03193 D-lactate dehydrogenase dld AlphaFold + ColabFold
1.1.5.12
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0050660Binding to FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2. GO:0006089The chemical reactions and pathways involving lactate, the anion of lactic acid. +1013 total
0.995 No Hit 0.0% —
62 KP13_00964 Anaerobic glycerol-3-phosphate dehydrogenase subunit C glpC AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0009061The enzymatic release of energy from inorganic and organic compounds (especially carbohydrates and fats) which uses compounds other than oxygen (e.g. nitrate, sulfate) as the terminal electron acceptor. GO:0051536Binding to an iron-sulfur cluster, a combination of iron and sulfur atoms. +58 total
0.995 No Hit 0.0% —
63 KP13_00579 1,4-dihydroxy-2-naphthoate octaprenyltransferase menA AlphaFold + ColabFold
2.5.1.74
GO:0004659Catalysis of the transfer of a prenyl group from one compound (donor) to another (acceptor). GO:0009234The chemical reactions and pathways resulting in the formation of any of the menaquinones. Structurally, menaquinones consist of a methylated naphthoquinone ring structure and side chains composed of a variable number of unsaturated isoprenoid residues. Menaquinones that have vitamin K activity and are known as vitamin K2. GO:0046428Catalysis of the reaction: 1,4-dihydroxy-2-naphthoate + an all-trans-polyprenyl diphosphate + H+ = a 2-demethylmenaquinol + CO2 + diphosphate. +47 total
0.995 Hit 28.9% 2.74e-20
64 KP13_04739 putative sugar efflux transporter sotB AlphaFold + ColabFold –
GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
0.994 No Hit 0.0% —
65 KP13_04568 hypothetical protein AlphaFold + ColabFold –
GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.
0.994 No Hit 0.0% —
66 KP13_04337 Inner membrane protein AlphaFold + ColabFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
0.994 No Hit 0.0% —
67 KP13_04231 Hydroxylamine reductase hcp AlphaFold + ColabFold
1.7.99.1
GO:0016661Catalysis of an oxidation-reduction (redox) reaction in which a nitrogenous group, excluding NH and NH2 groups, acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. +710 total
0.994 No Hit 0.0% —
68 KP13_03457 putative cation-transporting ATPase F ctpF AlphaFold + ColabFold –
GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. GO:0005215Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, accross or in between cells. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. +1114 total
0.994 Hit 47.7% 7.17e-21
69 KP13_02851 Dihydroxyacetone kinase AlphaFold + ColabFold
2.7.1.29
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0004371Catalysis of the reaction: ATP + glycerone = ADP + glycerone phosphate + 2 H+. GO:0006071The chemical reactions and pathways involving glycerol, 1,2,3-propanetriol, a sweet, hygroscopic, viscous liquid, widely distributed in nature as a constituent of many lipids. +25 total
0.994 Hit 50.3% 6.54e-42
70 KP13_00377 4-hydroxybenzoate octaprenyltransferase ubiA AlphaFold + ColabFold
2.5.1.39
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0004659Catalysis of the transfer of a prenyl group from one compound (donor) to another (acceptor). GO:0016765Catalysis of the transfer of an alkyl or aryl (but not methyl) group from one compound (donor) to another (acceptor). +36 total
0.994 Hit 39.6% 2.58e-25
71 KP13_32020 hypothetical protein AlphaFold + ColabFold – – 0.993 No Hit 0.0% —
72 KP13_07673 Tetracycline resistance protein, TetB AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. +14 total
0.993 No Hit 0.0% —
73 KP13_07168 ATP synthase protein I atpI AlphaFold + ColabFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
0.993 No Hit 0.0% —
74 KP13_05210 Putative metabolite transport protein AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. +25 total
0.993 Hit 36.2% 9.02e-46
75 KP13_04325 putative glucarate transporter AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.
0.993 Hit 25.3% 7.83e-17
Page of 208 · 5192 total proteins