Proteins

Genome: KpKP13

Description: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence

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5842 proteins

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# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
751 KP13_04672 Phenylalanyl-tRNA synthetase beta chain pheT AlphaFold + ColabFold
6.1.1.20
GO:0004826Catalysis of the reaction: ATP + L-phenylalanine + tRNA(Phe) = AMP + diphosphate + L-phenylalanyl-tRNA(Phe). GO:0000049Binding to a transfer RNA. GO:0006432The process of coupling phenylalanine to phenylalanyl-tRNA, catalyzed by phenylalanyl-tRNA synthetase. The phenylalanyl-tRNA synthetase is a class-II synthetase. However, unlike other class II enzymes, The activated amino acid is transferred to the 2'-OH group of a phenylalanine-accepting tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification. +47 total
0.821 Hit 22.7% 5.50e-10
752 KP13_04544 Inorganic pyrophosphatase AlphaFold + ColabFold
3.6.1.1
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0006796The chemical reactions and pathways involving the phosphate group, the anion or salt of any phosphoric acid. GO:0000287Binding to a magnesium (Mg) ion. +14 total
0.633 Hit 35.3% 5.61e-10
753 KP13_02471 fructosamine deglycase AlphaFold + ColabFold –
GO:1901135The chemical reactions and pathways involving carbohydrate derivative. GO:0097367Binding to a carbohydrate derivative. GO:0004360Catalysis of the reaction: D-fructose 6-phosphate + L-glutamine = D-glucosamine 6-phosphate + L-glutamate. +36 total
0.303 Hit 22.7% 5.64e-10
754 KP13_13160 Glucose-1-phosphate thymidylyltransferase 2 rmlA2 AlphaFold + ColabFold
2.7.7.24
GO:0045226OBSOLETE. The chemical reactions and pathways resulting in the formation of polysaccharides used in extracellular structures. GO:0009058A cellular process consisting of the biochemical pathways by which a living organism synthesizes chemical substances. This typically represents the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. GO:0008879Catalysis of the reaction: alpha-D-glucose 1-phosphate + dTTP = diphosphate + dTDP-glucose. +14 total
0.159 Hit 33.7% 6.45e-10
755 KP13_01563 Ribonuclease D rnd AlphaFold + ColabFold
3.1.13.5
GO:0044237OBSOLETE. The chemical reactions and pathways by which individual cells transform chemical substances. GO:0003676Binding to a nucleic acid. GO:0033890Catalysis of the exonucleolytic cleavage that removes extra residues from the 3'-terminus of tRNA to produce 5'-mononucleotides. +69 total
0.349 Hit 25.5% 6.64e-10
756 KP13_01823 H(+)/Cl(-) exchange transporter ClcA clcA AlphaFold + ColabFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0005247Enables the transmembrane transfer of a chloride ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded. GO:0015108Enables the transfer of chloride ions from one side of a membrane to the other. +47 total
0.581 Hit 32.7% 6.76e-10
757 KP13_04943 Multidrug resistance protein mdtG AlphaFold + ColabFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.
0.866 Hit 31.4% 6.78e-10
758 KP13_31541 DNA mismatch repair protein mutS mutS AlphaFold + ColabFold –
GO:0140664A molecule that recognises toxic DNA structures, and initiates a signaling response, driven by ATP hydrolysis. GO:0006298A system for the correction of errors in which an incorrect base, which cannot form hydrogen bonds with the corresponding base in the parent strand, is incorporated into the daughter strand. The mismatch repair system promotes genomic fidelity by repairing base-base mismatches, insertion-deletion loops and heterologies generated during DNA replication and recombination. GO:0030983Binding to a double-stranded DNA region containing one or more mismatches. +36 total
0.534 Hit 61.5% 6.97e-10
759 KP13_04109 putative HTH-type transcriptional regulator AlphaFold + ColabFold –
GO:0030170Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0009058A cellular process consisting of the biochemical pathways by which a living organism synthesizes chemical substances. This typically represents the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. +36 total
0.562 Hit 23.6% 7.62e-10
760 KP13_03380 putative MFS general substrate transporter AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. +47 total
0.745 Hit 31.2% 7.93e-10
761 KP13_03387 putative ABC transporter AlphaFold + ColabFold –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.
0.767 Hit 37.1% 8.10e-10
762 KP13_31537 Cytidine deaminase cdd Experimental + ColabFold –
GO:0008270Binding to a zinc ion (Zn). GO:0016787Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. GO:0009972OBSOLETE. The removal of amino group in the presence of water. +25 total
0.587 Hit 33.0% 8.18e-10
763 KP13_03470 Putative phosphosugar isomerase AlphaFold + ColabFold –
GO:1901135The chemical reactions and pathways involving carbohydrate derivative. GO:0097367Binding to a carbohydrate derivative.
0.07 Hit 22.9% 8.78e-10
764 KP13_02768 hypothetical protein AlphaFold + ColabFold –
GO:0016787Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc.
0.441 Hit 26.6% 8.92e-10
765 KP13_02452 putative oxidoreductase AlphaFold + ColabFold – – 0.772 Hit 58.0% 8.94e-10
766 KP13_02602 Protein recA recA AlphaFold + ColabFold –
GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. GO:0140664A molecule that recognises toxic DNA structures, and initiates a signaling response, driven by ATP hydrolysis. GO:0006281The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. +912 total
0.493 Hit 27.1% 8.97e-10
767 KP13_01827 Iron(3+)-hydroxamate import ATP-binding protein fhuC fhuC AlphaFold + ColabFold –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. +14 total
0.623 Hit 34.4% 9.49e-10
768 KP13_02200 Isopentenyl-diphosphate Delta-isomerase idi AlphaFold + ColabFold
5.3.3.2
GO:0004452Catalysis of the reaction: isopentenyl diphosphate = dimethylallyl diphosphate. GO:0008299The chemical reactions and pathways resulting in the formation of an isoprenoid compound, isoprene (2-methylbuta-1,3-diene) or compounds containing or derived from linked isoprene (3-methyl-2-butenylene) residues. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. +25 total
0.704 Hit 34.6% 9.72e-10
769 KP13_04914 Thymidylate kinase tmk AlphaFold + ColabFold
2.7.4.9
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0004798Catalysis of the reaction: dTMP + ATP = dTDP + ADP. GO:0006233The chemical reactions and pathways resulting in the formation of dTDP, deoxyribosylthymine diphosphate (2'-deoxyribosylthymine5'-diphosphate). +36 total
0.734 Hit 29.4% 1.04e-09
770 KP13_02588 Nitric oxide reductase FlRd-NAD(+) reductase norW AlphaFold + ColabFold
1.18.1.-
GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. GO:0016731Catalysis of an oxidation-reduction (redox) reaction in which an iron-sulfur protein acts as a hydrogen or electron donor and reduces NAD or NADP. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
0.902 Hit 33.1% 1.13e-09
771 KP13_00800 putative tRNA/rRNA methyltransferase AlphaFold + ColabFold –
GO:0008173Catalysis of the transfer of a methyl group from a donor to a nucleoside residue in an RNA molecule. GO:0003723Binding to an RNA molecule or a portion thereof. GO:0006396Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. +36 total
0.284 Hit 31.9% 1.17e-09
772 KP13_02187 6-phospho-beta-glucosidase bglA bglA AlphaFold + ColabFold –
GO:0005975The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. GO:0004553Catalysis of the hydrolysis of any O-glycosyl bond. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. +25 total
0.954 Hit 39.3% 1.25e-09
773 KP13_02246 Putative oxidoreductase AlphaFold + ColabFold –
GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
0.882 Hit 24.2% 1.25e-09
774 KP13_04302 Inner membrane protein AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.
0.894 Hit 31.8% 1.25e-09
775 KP13_03762 Inner membrane transport protein AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. +25 total
0.566 Hit 26.9% 1.26e-09
Page of 234 · 5842 total proteins