Proteins

Genome: KpKP13

Description: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence

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5842 proteins

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# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
76 KP13_04231 Hydroxylamine reductase hcp AlphaFold + ColabFold
1.7.99.1
GO:0016661Catalysis of an oxidation-reduction (redox) reaction in which a nitrogenous group, excluding NH and NH2 groups, acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. +710 total
0.994 No Hit 0.0% —
77 KP13_03591 UDP-2,3-diacylglucosamine hydrolase lpxH Experimental + ColabFold –
GO:0016462Catalysis of the hydrolysis of a pyrophosphate bond (diphosphate bond) between two phosphate groups. GO:0009245The chemical reactions and pathways resulting in the formation of lipid A, the glycolipid group of bacterial lipopolysaccharides, consisting of four to six fatty acyl chains linked to two glucosamine residues. Further modifications of the backbone are common. GO:0016787Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. +14 total
0.994 No Hit 0.0% —
78 KP13_03457 putative cation-transporting ATPase F ctpF AlphaFold + ColabFold –
GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. GO:0005215Enables the directed movement of substances (such as macromolecules, small molecules, ions) into, out of or within a cell, accross or in between cells. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. +1114 total
0.994 Hit 47.7% 7.17e-21
79 KP13_02851 Dihydroxyacetone kinase AlphaFold + ColabFold
2.7.1.29
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0004371Catalysis of the reaction: ATP + glycerone = ADP + glycerone phosphate + 2 H+. GO:0006071The chemical reactions and pathways involving glycerol, 1,2,3-propanetriol, a sweet, hygroscopic, viscous liquid, widely distributed in nature as a constituent of many lipids. +25 total
0.994 Hit 50.3% 6.54e-42
80 KP13_00377 4-hydroxybenzoate octaprenyltransferase ubiA AlphaFold + ColabFold
2.5.1.39
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0004659Catalysis of the transfer of a prenyl group from one compound (donor) to another (acceptor). GO:0016765Catalysis of the transfer of an alkyl or aryl (but not methyl) group from one compound (donor) to another (acceptor). +36 total
0.994 Hit 39.6% 2.58e-25
81 KP13_32020 hypothetical protein AlphaFold + ColabFold – – 0.993 No Hit 0.0% —
82 KP13_32016 hypothetical protein ColabFold – – 0.993 No Hit 0.0% —
83 KP13_31964 hypothetical protein ColabFold – – 0.993 No Hit 0.0% —
84 KP13_07673 Tetracycline resistance protein, TetB AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. +14 total
0.993 No Hit 0.0% —
85 KP13_07168 ATP synthase protein I atpI AlphaFold + ColabFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
0.993 No Hit 0.0% —
86 KP13_05210 Putative metabolite transport protein AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. +25 total
0.993 Hit 36.2% 9.02e-46
87 KP13_04325 putative glucarate transporter AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.
0.993 Hit 25.3% 7.83e-17
88 KP13_03850 Ethanolamine utilization protein eutG eutG AlphaFold + ColabFold –
GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. GO:0046872Binding to a metal ion. GO:0004022Catalysis of the reaction: an alcohol + NAD+ = an aldehyde or ketone + NADH + H+.
0.993 Hit 25.4% 5.42e-21
89 KP13_03600 putative oxidoreductase AlphaFold + ColabFold –
GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. GO:0008202The chemical reactions and pathways involving steroids, compounds with a 1,2,cyclopentanoperhydrophenanthrene nucleus.
0.993 Hit 50.0% 8.77e-11
90 KP13_03476 putative MFS general substrate transporter AlphaFold + ColabFold –
GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.
0.993 No Hit 0.0% —
91 KP13_01232 Inner membrane protein AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
0.993 No Hit 0.0% —
92 KP13_00684 Ferrous iron transport protein B feoB AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0015093Enables the transfer of ferrous iron (Fe(II) or Fe2+) ions from one side of a membrane to the other. GO:0006826The directed movement of iron (Fe) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. +14 total
0.993 No Hit 0.0% —
93 KP13_00147 Protein AsmA AlphaFold + ColabFold – – 0.993 No Hit 0.0% —
94 KP13_05233 Purine ribonucleoside efflux pump nepI AlphaFold + ColabFold –
GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
0.992 No Hit 0.0% —
95 KP13_04823 Yersiniabactin biosynthesis thioesterase AlphaFold + ColabFold –
GO:0009058A cellular process consisting of the biochemical pathways by which a living organism synthesizes chemical substances. This typically represents the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. GO:0008610The chemical reactions and pathways resulting in the formation of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent.
0.992 Hit 27.5% 4.28e-10
96 KP13_04543 hypothetical protein ColabFold – – 0.992 No Hit 0.0% —
97 KP13_01693 dTDP-glucose 4,6-dehydratase rffG AlphaFold + ColabFold
4.2.1.46
GO:0008460Catalysis of the reaction: dTDP-glucose = dTDP-4-dehydro-6-deoxy-alpha-D-glucose + H2O. GO:0009225The cellular chemical reactions and pathways involving nucleotide-sugars, any nucleotide-carbohydrate in which the distal phosphoric residue of a nucleoside 5'-diphosphate is in glycosidic linkage with a monosaccharide or monosaccharide derivative.
0.992 Hit 34.7% 3.09e-10
98 KP13_00940 Inner membrane protein AlphaFold + ColabFold –
GO:0008484Catalysis of the reaction: RSO-R' + H2O = RSOOH + R'H. This reaction is the hydrolysis of a sulfuric ester bond, an ester formed from sulfuric acid, O=SO(OH)2. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
0.992 No Hit 0.0% —
99 KP13_31530 dTDP-D-glucose 4,6-dehydratase in cps region rmlB AlphaFold + ColabFold
4.2.1.46
GO:0008460Catalysis of the reaction: dTDP-glucose = dTDP-4-dehydro-6-deoxy-alpha-D-glucose + H2O. GO:0009225The cellular chemical reactions and pathways involving nucleotide-sugars, any nucleotide-carbohydrate in which the distal phosphoric residue of a nucleoside 5'-diphosphate is in glycosidic linkage with a monosaccharide or monosaccharide derivative.
0.991 Hit 35.0% 1.03e-65
100 KP13_04687 YceI-like domain-containing protein AlphaFold + ColabFold – – 0.991 No Hit 0.0% —
Page of 234 · 5842 total proteins