Proteins

Genome: KpKP13

Description: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence

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5842 proteins

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# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
1126 KP13_03752 putative oxidoreductase AlphaFold + ColabFold –
GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. GO:0051596The chemical reactions and pathways resulting in the breakdown of methylglyoxal, CH3-CO-CHO, the aldehyde of pyruvic acid.
0.389 Hit 40.7% 1.54e-06
1127 KP13_00823 Phosphoribosylformylglycinamidine synthase purL AlphaFold + ColabFold
6.3.5.3
GO:0006189The chemical reactions and pathways resulting in the formation of IMP, inosine monophosphate, by the stepwise assembly of a purine ring on ribose 5-phosphate. GO:0004642Catalysis of the reaction: N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide + L-glutamine + ATP + H2O = 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine + L-glutamate + ADP + 2 H+ + phosphate. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. +25 total
0.899 Hit 46.5% 1.55e-06
1128 KP13_03328 Glutamate/aspartate transport ATP-binding protein gltL gltL AlphaFold + ColabFold –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. GO:0003333The process in which an amino acid is transported across a membrane. +25 total
0.638 Hit 61.1% 1.58e-06
1129 KP13_00213 Glycerol-3-phosphate dehydrogenase [NAD(P)+] gpsA AlphaFold + ColabFold
1.1.1.94
GO:0016616Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP. GO:0047952Catalysis of the reaction: sn-glycerol 3-phosphate + NAD(P)+ = glycerone phosphate + NAD(P)H + H+. GO:0046168The chemical reactions and pathways resulting in the breakdown of glycerol-3-phosphate, a phosphoric monoester of glycerol. +1013 total
0.971 Hit 33.0% 1.60e-06
1130 KP13_04132 hypothetical protein AlphaFold + ColabFold – – 0.912 Hit 28.3% 1.65e-06
1131 KP13_04496 Glutamate transport ATP-binding protein gluA gluA AlphaFold + ColabFold –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. GO:0003333The process in which an amino acid is transported across a membrane. +25 total
0.375 Hit 60.0% 1.67e-06
1132 KP13_01488 Sulphatase-modifying factor domain-containing protein AlphaFold + ColabFold –
GO:0120147Catalysis of the reaction: A [sulfatase]-L-cysteine + O2 + 2 a thiol = a [sulfatase]-3-oxo-L-alanine + hydrogen sulfide + a disulfide + H2O.
0.428 Hit 35.3% 1.71e-06
1133 KP13_04242 Arginine transport ATP-binding protein artP artP AlphaFold + ColabFold
7.4.2.1
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. GO:0003333The process in which an amino acid is transported across a membrane. +36 total
0.517 Hit 53.8% 1.71e-06
1134 KP13_03544 Sulfate/thiosulfate import ATP-binding protein cysA cysA AlphaFold + ColabFold –
GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. GO:0015419Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + sulfate(out) = ADP + phosphate + sulfate(in). GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. +36 total
0.867 Hit 55.0% 1.73e-06
1135 KP13_06717 DnaJ domain-containing protein AlphaFold + ColabFold – – 0.855 Hit 42.6% 1.73e-06
1136 KP13_00157 Triosephosphate isomerase tpiA AlphaFold + ColabFold
5.3.1.1
GO:0004807Catalysis of the reaction: D-glyceraldehyde 3-phosphate = dihydroxyacetone phosphate. GO:0006096The chemical reactions and pathways resulting in the breakdown of a carbohydrate into pyruvate, with the concomitant production of a small amount of ATP and the reduction of NAD(P) to NAD(P)H. Glycolysis begins with the metabolism of a carbohydrate to generate products that can enter the pathway and ends with the production of pyruvate. Pyruvate may be converted to acetyl-coenzyme A, ethanol, lactate, or other small molecules. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. +36 total
0.766 Hit 57.6% 1.74e-06
1137 KP13_00256 2-dehydro-3-deoxygluconokinase kdgK AlphaFold + ColabFold –
GO:0016301Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator.
0.83 Hit 25.5% 1.75e-06
1138 KP13_03161 Mandelate racemase/muconate lactonizing enzyme family protein AlphaFold + ColabFold –
GO:0016836Catalysis of the cleavage of a carbon-oxygen bond by elimination of water. GO:0000287Binding to a magnesium (Mg) ion. GO:0016052The chemical reactions and pathways resulting in the breakdown of carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y.
0.542 Hit 25.4% 1.75e-06
1139 KP13_03168 Ribitol 2-dehydrogenase rbtD AlphaFold + ColabFold –
GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
0.636 Hit 51.1% 1.76e-06
1140 KP13_04324 short-chain type dehydrogenase/reductase AlphaFold + ColabFold –
GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. GO:0016616Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP. GO:0030497The elongation of a fatty acid chain by the sequential addition of two-carbon units.
0.766 Hit 41.3% 1.79e-06
1141 KP13_02909 GABA permease gabP AlphaFold + ColabFold –
GO:0015812The directed movement of gamma-aminobutyric acid (GABA, 4-aminobutyrate), an amino acid which acts as a neurotransmitter in some organisms, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. GO:0006865The directed movement of amino acids, organic acids containing one or more amino substituents, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. +36 total
0.732 Hit 24.5% 1.82e-06
1142 KP13_00166 Guanylate kinase gmk AlphaFold + ColabFold
2.7.4.8
GO:0004385Catalysis of the reaction: ATP + GMP = ADP + GDP. GO:0006163The chemical reactions and pathways involving a purine nucleotide, a compound consisting of nucleoside (a purine base linked to a deoxyribose or ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. +14 total
0.156 Hit 52.2% 1.84e-06
1143 KP13_05376 Acyl-CoA thioester hydrolase AlphaFold + ColabFold –
GO:0016790Catalysis of the reaction: RCO-SR' + H2O = RCOOH + HSR'. This reaction is the hydrolysis of a thiolester bond, an ester formed from a carboxylic acid and a thiol (i.e., RCO-SR'), such as that found in acetyl-coenzyme A. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0052816Catalysis of the reaction: a long-chain fatty acyl-CoA + H2O = a long-chain fatty acid + CoA + H+. A long-chain fatty acid has an aliphatic tail containing 13 to 22 carbons. +25 total
0.261 Hit 31.9% 1.87e-06
1144 KP13_03373 Carbohydrate kinase, FGGY family protein AlphaFold + ColabFold –
GO:0005975The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. GO:0016301Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule.
0.369 Hit 27.7% 1.89e-06
1145 KP13_04234 Pyruvate dehydrogenase ubiquinone poxB AlphaFold + ColabFold
1.2.5.1
GO:0030976Binding to thiamine pyrophosphate, the diphosphoric ester of thiamine. Acts as a coenzyme of several (de)carboxylases, transketolases, and alpha-oxoacid dehydrogenases. GO:0052737Catalysis of the reaction: a ubiquinone + H2O + pyruvate = a ubiquinol + acetate + CO2. GO:0000287Binding to a magnesium (Mg) ion. +710 total
0.814 Hit 31.0% 1.90e-06
1146 KP13_05399 Succinylornithine transaminase AlphaFold + ColabFold –
GO:0030170Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. GO:0008483Catalysis of the transfer of an amino group to an acceptor, usually a 2-oxo acid. GO:0006525The chemical reactions and pathways involving arginine, 2-amino-5-(carbamimidamido)pentanoic acid. +25 total
0.416 Hit 37.1% 1.90e-06
1147 KP13_00016 tRNA uridine 5-carboxymethylaminomethyl modification enzyme mnmG mnmG AlphaFold + ColabFold –
GO:0002098The process in which a uridine at position 34 of a tRNA is post-transcriptionally modified. The wobble nucleoside of the tRNA sequence (position 34) corresponds to the first position of the anticodon. GO:0005515Binding to a protein. GO:0008033The process in which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group. +36 total
0.616 Hit 76.3% 1.92e-06
1148 KP13_00755 30S ribosomal protein S3 rpsC AlphaFold + ColabFold –
GO:0003723Binding to an RNA molecule or a portion thereof. GO:0003676Binding to a nucleic acid. GO:0006412The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome. +47 total
0.439 Hit 28.7% 1.94e-06
1149 KP13_04545 HTH-type DNA-binding domain-containing acetyltransferase AlphaFold + ColabFold –
GO:0016747Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. +14 total
0.957 Hit 30.2% 2.10e-06
1150 KP13_05437 Peptide transport system ATP-binding protein sapD sapD AlphaFold + ColabFold –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. GO:0015833The directed movement of peptides, compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. +25 total
0.461 Hit 33.3% 2.16e-06
Page of 234 · 5842 total proteins