Proteins

Genome: KpKP13

Description: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence

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5192 / 5842 proteins Structure: AlphaFold

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Structure: AlphaFold ×
# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
1451 KP13_02001 Protein creA creA AlphaFold + ColabFold –
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
0.76 No Hit 0.0% —
1452 KP13_01743 Xaa-Pro dipeptidase pepQ AlphaFold + ColabFold
3.4.13.9
GO:0016795Catalysis of the hydrolysis of a phosphoric triester. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0004177Catalysis of the hydrolysis of a single N-terminal amino acid residue from a polypeptide chain. +47 total
0.76 Hit 33.2% 9.09e-37
1453 KP13_01043 3-ketoacyl-CoA thiolase fadI AlphaFold + ColabFold
2.3.1.16
GO:0016746Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor). GO:0016042The chemical reactions and pathways resulting in the breakdown of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. +58 total
0.76 Hit 47.8% 7.17e-59
1454 KP13_32009 hypothetical protein AlphaFold + ColabFold – – 0.759 No Hit 0.0% —
1455 KP13_05505 hypothetical protein AlphaFold + ColabFold – – 0.759 No Hit 0.0% —
1456 KP13_04305 Outer membrane protein X ompX AlphaFold + ColabFold –
GO:0044384The external membrane of Gram-negative bacteria or certain organelles such as mitochondria and chloroplasts; freely permeable to most ions and metabolites, occurring in a host cell. GO:0009279A lipid bilayer that forms the outermost membrane of the cell envelope; enriched in polysaccharide and protein; the outer leaflet of the membrane contains specific lipopolysaccharide structures.
0.759 No Hit 0.0% —
1457 KP13_03727 hypothetical protein AlphaFold + ColabFold – – 0.759 No Hit 0.0% —
1458 KP13_02125 Amino acid ABC superfamily ATP binding cassette transporter, membrane protein AlphaFold + ColabFold –
GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0043190A complex for the transport of metabolites into and out of the cell, typically comprised of four domains; two membrane-associated domains and two ATP-binding domains at the intracellular face of the membrane, that form a central pore through the plasma membrane. Each of the four core domains may be encoded as a separate polypeptide or the domains can be fused in any one of a number of ways into multidomain polypeptides. In Bacteria and Archaebacteria, ABC transporters also include substrate binding proteins to bind substrate external to the cytoplasm and deliver it to the transporter. +36 total
0.759 No Hit 0.0% —
1459 KP13_01677 hypothetical protein AlphaFold + ColabFold – – 0.759 No Hit 0.0% —
1460 KP13_01018 hypothetical protein AlphaFold + ColabFold – – 0.759 No Hit 0.0% —
1461 KP13_00259 Inner membrane lipoprotein AlphaFold + ColabFold –
GO:0009279A lipid bilayer that forms the outermost membrane of the cell envelope; enriched in polysaccharide and protein; the outer leaflet of the membrane contains specific lipopolysaccharide structures. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
0.759 No Hit 0.0% —
1462 KP13_31786 hypothetical protein AlphaFold + ColabFold – – 0.758 No Hit 0.0% —
1463 KP13_04406 putative oxidoreductase AlphaFold + ColabFold –
GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0019594The chemical reactions and pathways involving mannitol, the alditol derived from D-mannose by reduction of the aldehyde group. +14 total
0.758 No Hit 0.0% —
1464 KP13_03674 ATP-dependent protease La lon AlphaFold + ColabFold
3.4.21.53
GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. GO:0004252Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). GO:0030163The chemical reactions and pathways resulting in the breakdown of a protein by the destruction of the native, active configuration, with or without the hydrolysis of peptide bonds. +710 total
0.758 Hit 54.8% 9.05e-63
1465 KP13_03029 Dethiobiotin synthetase bioD AlphaFold + ColabFold –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0009102The chemical reactions and pathways resulting in the formation of biotin, cis-tetrahydro-2-oxothieno(3,4-d)imidazoline-4-valeric acid. GO:0000287Binding to a magnesium (Mg) ion. +14 total
0.758 No Hit 0.0% —
1466 KP13_02382 Glucarate dehydratase gudD AlphaFold + ColabFold
4.2.1.40
GO:0019394OBSOLETE. The chemical reactions and pathways resulting in the breakdown of glucarate, the anion of glucaric acid. GO:0000287Binding to a magnesium (Mg) ion. GO:0008872Catalysis of the reaction: D-glucarate = 5-dehydro-4-deoxy-D-glucarate + H2O. +14 total
0.758 No Hit 0.0% —
1467 KP13_05569 Lactonase drp35 drp35 AlphaFold + ColabFold –
GO:0016787Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc.
0.757 No Hit 0.0% —
1468 KP13_03867 hypothetical protein AlphaFold + ColabFold – – 0.757 No Hit 0.0% —
1469 KP13_02743 tRNA (guanine-N(7)-)-methyltransferase trmB AlphaFold + ColabFold
2.1.1.33
GO:0008176Catalysis of the reaction: guanosine46 in tRNA + S-adenosyl-L-methionine = N7-methylguanosine46 in tRNA + S-adenosyl-L-homocysteine. GO:0006400The covalent alteration of one or more nucleotides within a tRNA molecule to produce a tRNA molecule with a sequence that differs from that coded genetically. GO:0043527A multimeric protein complex involved in the methylation of specific nucleotides in tRNA.
0.757 Hit 27.1% 6.87e-06
1470 KP13_01990 hypothetical protein AlphaFold + ColabFold – – 0.757 No Hit 0.0% —
1471 KP13_01884 Inner membrane symporter AlphaFold + ColabFold –
GO:0015293Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported together in the same direction in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0006814The directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. +25 total
0.757 Hit 28.7% 8.62e-09
1472 KP13_01637 Universal stress protein C uspC AlphaFold + ColabFold –
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
0.757 No Hit 0.0% —
1473 KP13_02557 Cellobiose permease IIC component AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0009401The uptake and phosphorylation of specific carbohydrates from the extracellular environment; uptake and phosphorylation are coupled, making the PTS a link between the uptake and metabolism of sugars; phosphoenolpyruvate is the original phosphate donor; phosphoenolpyruvate passes the phosphate via a signal transduction pathway, to enzyme 1 (E1), which in turn passes it on to the histidine protein, HPr; the next step in the system involves sugar-specific membrane-bound complex, enzyme 2 (EII), which transports the sugar into the cell; it includes the sugar permease, which catalyzes the transport reactions; EII is usually divided into three different domains, EIIA, EIIB, and EIIC. GO:0008982Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + sugar(out) = protein histidine + sugar phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport. +14 total
0.756 No Hit 0.0% —
1474 KP13_02375 hypothetical protein AlphaFold + ColabFold – – 0.756 No Hit 0.0% —
1475 KP13_00926 Alkaline-phosphatase-like protein AlphaFold + ColabFold –
GO:0008484Catalysis of the reaction: RSO-R' + H2O = RSOOH + R'H. This reaction is the hydrolysis of a sulfuric ester bond, an ester formed from sulfuric acid, O=SO(OH)2. GO:0004065Catalysis of the reaction: a phenol sulfate + H2O = a phenol + sulfate. GO:0015024Catalysis of the hydrolysis of the 2-sulfate groups of the 2-O-sulfo-D-glucuronate residues of chondroitin sulfate, heparin and heparitin sulfate.
0.756 Hit 32.4% 7.52e-06
Page of 208 · 5192 total proteins