Proteins

Genome: KpKP13

Description: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence

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5192 / 5842 proteins Structure: AlphaFold

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Structure: AlphaFold ×
# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
1801 KP13_03283 Citrate synthase gltA AlphaFold + ColabFold –
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0006099A nearly universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two CO2 and four pairs of electrons are transferred to coenzymes. The acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle. In eukaryotes the tricarboxylic acid is confined to the mitochondria. See also glyoxylate cycle. GO:0046912Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor), with the acyl group being converted into alkyl on transfer. +25 total
0.696 Hit 25.1% 4.23e-23
1802 KP13_02221 hypothetical protein AlphaFold + ColabFold – – 0.696 No Hit 0.0% —
1803 KP13_02210 hypothetical protein AlphaFold + ColabFold – – 0.696 No Hit 0.0% —
1804 KP13_01611 Glucose-6-phosphate 1-dehydrogenase zwf AlphaFold + ColabFold
1.1.1.49
GO:0050661Binding to nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP+, or the reduced form, NADPH. GO:0006006The chemical reactions and pathways involving glucose, the aldohexose gluco-hexose. D-glucose is dextrorotatory and is sometimes known as dextrose; it is an important source of energy for living organisms and is found free as well as combined in homo- and hetero-oligosaccharides and polysaccharides. GO:0016614Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group act as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. +36 total
0.696 Hit 38.3% 1.11e-88
1805 KP13_31575 Plasmid segregation protein parM AlphaFold + ColabFold – – 0.695 No Hit 0.0% —
1806 KP13_04991 Succinylornithine transaminase astC AlphaFold + ColabFold
2.6.1.11 2.6.1.17
GO:0030170Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. GO:0008483Catalysis of the transfer of an amino group to an acceptor, usually a 2-oxo acid. GO:0006525The chemical reactions and pathways involving arginine, 2-amino-5-(carbamimidamido)pentanoic acid. +811 total
0.695 Hit 34.3% 2.45e-06
1807 KP13_04646 putative MFS-type transporter AlphaFold + ColabFold –
GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
0.695 No Hit 0.0% —
1808 KP13_04169 Aminopeptidase N pepN AlphaFold + ColabFold
3.4.11.2
GO:0006508The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds. GO:0008270Binding to a zinc ion (Zn). GO:0008237Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. +25 total
0.695 Hit 32.7% 3.63e-10
1809 KP13_02847 hypothetical protein AlphaFold + ColabFold – – 0.695 No Hit 0.0% —
1810 KP13_02499 4-hydroxyphenylacetate permease domain-containing protein AlphaFold + ColabFold –
GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. GO:1901241Enables the transfer of 4-hydroxyphenylacetate from one side of a membrane to the other. GO:1900754The directed movement of a 4-hydroxyphenylacetate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. +14 total
0.695 No Hit 0.0% —
1811 KP13_02217 Multidrug resistance outer membrane protein mdtP mdtP AlphaFold + ColabFold –
GO:0015562Enables the transfer of a specific substance or related group of substances from the inside of the cell to the outside of the cell across a membrane. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. +25 total
0.695 No Hit 0.0% —
1812 KP13_00967 L-rhamnonate dehydratase AlphaFold + ColabFold
4.2.1.90
GO:0050032Catalysis of the reaction: L-rhamnonate = 2-dehydro-3-deoxy-L-rhamnonate + H2O. GO:0009063The chemical reactions and pathways resulting in the breakdown of amino acids, organic acids containing one or more amino substituents. GO:0000287Binding to a magnesium (Mg) ion. +14 total
0.695 No Hit 0.0% —
1813 KP13_05616 hypothetical protein AlphaFold + ColabFold – – 0.694 No Hit 0.0% —
1814 KP13_03421 Glycerol kinase AlphaFold + ColabFold –
GO:0016773Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor). GO:0005975The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. GO:0016301Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. +47 total
0.694 Hit 34.7% 8.22e-85
1815 KP13_03101 hypothetical protein AlphaFold + ColabFold – – 0.694 No Hit 0.0% —
1816 KP13_02413 Bifunctional P-protein pheA AlphaFold + ColabFold
4.2.1.51 5.4.99.5
GO:0009094The chemical reactions and pathways resulting in the formation of L-phenylalanine, the L-enantiomer of 2-amino-3-phenylpropanoic acid, i.e. (2S)-2-amino-3-phenylpropanoic acid. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0046417The chemical reactions and pathways involving chorismate, the anion of (3R-trans)-3-((1-carboxyethenyl)oxy)-4-hydroxy-1,5-cyclohexadiene-1-carboxylic acid. +25 total
0.694 No Hit 0.0% —
1817 KP13_02105 Alpha-ketoglutarate-dependent taurine dioxygenase tauD AlphaFold + ColabFold –
GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0046872Binding to a metal ion. +25 total
0.694 No Hit 0.0% —
1818 KP13_05294 Beta-galactosidase 1 lacZ1 AlphaFold + ColabFold
3.2.1.23
GO:0030246Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates. GO:0005975The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. GO:0009341A protein complex that possesses beta-galactosidase activity, i.e. catalyzes the hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides. In E. coli, the complex is a homotetramer; dimeric and hexameric beta-galactosidase complexes have been observed in other species. +69 total
0.693 Hit 23.5% 4.84e-20
1819 KP13_01518 LysR family transcriptional regulator protein AlphaFold + ColabFold –
GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. +14 total
0.693 No Hit 0.0% —
1820 KP13_00030 Phosphate-binding protein pstS pstS AlphaFold + ColabFold –
GO:0043190A complex for the transport of metabolites into and out of the cell, typically comprised of four domains; two membrane-associated domains and two ATP-binding domains at the intracellular face of the membrane, that form a central pore through the plasma membrane. Each of the four core domains may be encoded as a separate polypeptide or the domains can be fused in any one of a number of ways into multidomain polypeptides. In Bacteria and Archaebacteria, ABC transporters also include substrate binding proteins to bind substrate external to the cytoplasm and deliver it to the transporter. GO:0035435The process in which a phosphate is transported across a membrane. GO:0042301Binding to a phosphate ion.
0.693 No Hit 0.0% —
1821 KP13_06739 conjugal transfer TraG-like protein traG AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
0.692 No Hit 0.0% —
1822 KP13_05346 hypothetical protein AlphaFold + ColabFold – – 0.692 No Hit 0.0% —
1823 KP13_02373 NADPH-dependent 7-cyano-7-deazaguanine reductase queF AlphaFold + ColabFold
1.7.1.13
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0046857Catalysis of an oxidation-reduction (redox) reaction in which a nitrogenous group, excluding NH and NH2 groups, acts as a hydrogen or electron donor and reduces NAD or NADP. GO:0033739Catalysis of the reaction: 7-aminomethyl-7-carbaguanine + 2 NADP+ = 7-cyano-7-deazaguanine + 2 NADPH + 3 H+. +14 total
0.692 No Hit 0.0% —
1824 KP13_00567 Metallo-dependent phosphatase AlphaFold + ColabFold –
GO:0009166The chemical reactions and pathways resulting in the breakdown of nucleotides, any nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the glycose moiety; may be mono-, di- or triphosphate; this definition includes cyclic-nucleotides (nucleoside cyclic phosphates). GO:0016787Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. GO:0046872Binding to a metal ion. +58 total
0.692 Hit 31.1% 5.56e-17
1825 KP13_00007 Ribose import ATP-binding protein rbsA rbsA AlphaFold + ColabFold –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. +14 total
0.692 Hit 36.3% 2.53e-06
Page of 208 · 5192 total proteins