Proteins

Genome: KpKP13

Description: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence

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5842 proteins

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# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
176 KP13_00293 2-dehydro-3-deoxygluconokinase AlphaFold + ColabFold
2.7.1.45
GO:0016301Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0008673Catalysis of the reaction: 2-dehydro-3-deoxy-D-gluconate + ATP = 2-dehydro-3-deoxy-6-phospho-D-gluconate + ADP + 2 H+. +47 total
0.228 No Hit 0.0% —
177 KP13_00294 hypothetical protein AlphaFold + ColabFold – – 0.208 No Hit 0.0% —
178 KP13_00295 AsmA family protein AlphaFold + ColabFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0090313Any process that modulates the frequency, rate or extent of the process of directing proteins towards a membrane, usually using signals contained within the protein.
0.99 No Hit 0.0% —
179 KP13_00297 hypothetical protein AlphaFold + ColabFold – – 0.401 No Hit 0.0% —
180 KP13_00298 Ribonuclease BN-related protein AlphaFold + ColabFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
0.976 No Hit 0.0% —
181 KP13_00299 LysR family transcriptional regulator AlphaFold + ColabFold –
GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0043565Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. +25 total
0.722 No Hit 0.0% —
182 KP13_00301 GCN5-related N-acetyltransferase AlphaFold + ColabFold –
GO:0016747Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor).
0.478 No Hit 0.0% —
183 KP13_00306 DNA methylase, N-6 adenine-specific protein AlphaFold + ColabFold
2.1.1.266
GO:0070475The addition of a methyl group to an atom in the nucleoside base portion of a nucleotide residue in an rRNA molecule. GO:0008168Catalysis of the transfer of a methyl group to an acceptor molecule. GO:0003676Binding to a nucleic acid. +58 total
0.946 No Hit 0.0% —
184 KP13_00307 Phosphatidic acid phosphatase family protein AlphaFold + ColabFold –
GO:0003993Catalysis of the reaction: an orthophosphoric monoester + H2O = an alcohol + phosphate, with an acid pH optimum. GO:0030288The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin peptidoglycan layer (PGL), also referred to as a thin cell wall.
0.837 No Hit 0.0% —
185 KP13_00309 putative methyltransferase AlphaFold + ColabFold
2.1.1.242
GO:0008990Catalysis of the reaction: S-adenosyl-L-methionine + rRNA = S-adenosyl-L-homocysteine + rRNA containing N2-methylguanine. GO:0031167The posttranscriptional addition of methyl groups to specific residues in an rRNA molecule. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
0.447 No Hit 0.0% —
186 KP13_00311 Universal stress protein A uspA AlphaFold + ColabFold –
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
0.448 No Hit 0.0% —
187 KP13_00312 Universal stress protein B uspB AlphaFold + ColabFold – – 0.747 No Hit 0.0% —
188 KP13_00314 FAD-dependent oxidoreductase AlphaFold + ColabFold – – 0.999 No Hit 0.0% —
189 KP13_00315 Magnesium transporter mgtE mgtE AlphaFold + ColabFold –
GO:0006812The directed movement of a monoatomic cation, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Monatomic cations (also called simple cations) are positively charged ions consisting of exactly one atom. GO:0008324Enables the transfer of cation from one side of a membrane to the other.
0.276 No Hit 0.0% —
190 KP13_00316 Nickel-responsive regulator nikR AlphaFold + ColabFold –
GO:0016151Binding to a nickel (Ni) cation. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0010045Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a nickel cation stimulus. +36 total
0.272 No Hit 0.0% —
191 KP13_00319 Nickel transport system permease protein nikC nikC AlphaFold + ColabFold –
GO:0015099Enables the transfer of nickel (Ni) cations from one side of a membrane to the other. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. +25 total
0.827 No Hit 0.0% —
192 KP13_00320 Nickel transport system permease protein nikB nikB AlphaFold + ColabFold –
GO:0015099Enables the transfer of nickel (Ni) cations from one side of a membrane to the other. GO:0035444The directed movement of nickel (Ni) cations across a membrane by means of some agent such as a transporter or pore. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. +14 total
0.566 No Hit 0.0% —
193 KP13_00321 Nickel-binding periplasmic protein nikA AlphaFold + ColabFold –
GO:0016151Binding to a nickel (Ni) cation. GO:0015675The directed movement of nickel (Ni) cations into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. GO:0043190A complex for the transport of metabolites into and out of the cell, typically comprised of four domains; two membrane-associated domains and two ATP-binding domains at the intracellular face of the membrane, that form a central pore through the plasma membrane. Each of the four core domains may be encoded as a separate polypeptide or the domains can be fused in any one of a number of ways into multidomain polypeptides. In Bacteria and Archaebacteria, ABC transporters also include substrate binding proteins to bind substrate external to the cytoplasm and deliver it to the transporter. +58 total
0.193 No Hit 0.0% —
194 KP13_00322 LysR family transcriptional regulator AlphaFold + ColabFold –
GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0000976Binding to a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon.
0.753 No Hit 0.0% —
195 KP13_00323 putative phenolic acid decarboxylase padC AlphaFold + ColabFold –
GO:0016831Catalysis of the nonhydrolytic addition or removal of a carboxyl group to or from a compound.
0.834 No Hit 0.0% —
196 KP13_00327 putative 4-deoxy-4-formamido-L-arabinose-phosphoundecaprenol deformylase ArnD arnD AlphaFold + ColabFold
3.5.1.n3
GO:0016811Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a linear amide. GO:0005975The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. GO:0016810Catalysis of the hydrolysis of any carbon-nitrogen bond, C-N, with the exception of peptide bonds. +58 total
0.709 No Hit 0.0% —
197 KP13_00328 Undecaprenyl phosphate-alpha-4-amino-4-deoxy-L-arabinose arabinosyl transferase arnT AlphaFold + ColabFold
2.4.2.43
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0006493A glycoprotein biosynthetic process starting with the covalent linkage of carbohydrate or carbohydrate derivative unit via a glycosidic bond to the oxygen atom of a serine, threonine, hydroxylysine, hydroxyproline or tyrosine side chain in a protein, which can be further elongated with the sequential addition of sugar units resulting in the formation of a protein O-linked glycan. GO:0016763Catalysis of the transfer of a pentosyl group from one compound (donor) to another (acceptor). +69 total
0.915 No Hit 0.0% —
198 KP13_00330 Undecaprenyl phosphate-aminoarabinose flippase subunit ArnF arnF AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0009103The chemical reactions and pathways resulting in the formation of lipopolysaccharides, any of a group of related, structurally complex components of the outer membrane of Gram-negative bacteria. GO:1901505Enables the transfer of carbohydrate derivative from one side of a membrane to the other. +14 total
0.665 No Hit 0.0% —
199 KP13_00331 PerM family protein AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.
0.817 No Hit 0.0% —
200 KP13_00332 Major facilitator superfamily MFS-1 protein AlphaFold + ColabFold –
GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
0.933 No Hit 0.0% —
Page of 234 · 5842 total proteins