Proteins

Genome: KpKP13

Description: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence

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5192 / 5842 proteins Structure: AlphaFold

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Structure: AlphaFold ×
# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
2051 KP13_00664 Glycogen debranching enzyme glgX AlphaFold + ColabFold
3.2.1.196
GO:0005980The chemical reactions and pathways resulting in the breakdown of glycogen, a polydisperse, highly branched glucan composed of chains of D-glucose residues. GO:0005975The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. GO:0004553Catalysis of the hydrolysis of any O-glycosyl bond. +36 total
0.651 No Hit 0.0% —
2052 KP13_00655 hypothetical protein AlphaFold + ColabFold – – 0.651 No Hit 0.0% —
2053 KP13_06650 Integrase/recombinase AlphaFold + ColabFold –
GO:0006310Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Interchromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0015074The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome. +14 total
0.65 No Hit 0.0% —
2054 KP13_01791 tRNA(Ile)-lysidine synthase tilS AlphaFold + ColabFold
6.3.4.19
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0016879Catalysis of the joining of two molecules, or two groups within a single molecule, via a carbon-nitrogen bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate. GO:0008033The process in which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group. +47 total
0.65 No Hit 0.0% —
2055 KP13_01740 NAD(P)H-flavin reductase fre AlphaFold + ColabFold
1.5.1.41
GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. GO:0052875Catalysis of the reaction: reduced riboflavin + NAD(P)+ = riboflavin + NAD(P)H + 2 H+. This reaction can utilize NADH and NADPH. GO:0006826The directed movement of iron (Fe) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
0.65 Hit 23.4% 7.88e-06
2056 KP13_00459 Protein phnA phnA AlphaFold + ColabFold – – 0.65 No Hit 0.0% —
2057 KP13_00165 DNA-directed RNA polymerase subunit omega rpoZ AlphaFold + ColabFold
2.7.7.6
GO:0003899Catalysis of the reaction: nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1). Utilizes a DNA template, i.e. the catalysis of DNA-template-directed extension of the 3'-end of an RNA strand by one nucleotide at a time. Can initiate a chain 'de novo'. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0006351The synthesis of an RNA transcript from a DNA template. +14 total
0.65 No Hit 0.0% —
2058 KP13_31518 3-dehydroquinate dehydratase aroQ AlphaFold + ColabFold
4.2.1.10
GO:0003855Catalysis of the reaction: 3-dehydroquinate = 3-dehydroshikimate + H2O. GO:0008652The chemical reactions and pathways resulting in the formation of amino acids, organic acids containing one or more amino substituents. GO:0009073The chemical reactions and pathways resulting in the formation of aromatic amino acid family, amino acids with aromatic ring (phenylalanine, tyrosine, tryptophan). +25 total
0.649 No Hit 0.0% —
2059 KP13_04364 HTH-type transcriptional activator nahR nahR AlphaFold + ColabFold –
GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
0.649 No Hit 0.0% —
2060 KP13_03571 putative cadaverine/lysine antiporter cadB AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0006865The directed movement of amino acids, organic acids containing one or more amino substituents, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. +25 total
0.649 Hit 28.6% 7.58e-08
2061 KP13_02844 Glycerol metabolism operon regulatory protein dhaR AlphaFold + ColabFold –
GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0043565Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. +36 total
0.649 No Hit 0.0% —
2062 KP13_02592 Glucitol operon activator protein gutM AlphaFold + ColabFold – – 0.649 No Hit 0.0% —
2063 KP13_02146 hypothetical protein AlphaFold + ColabFold – – 0.649 No Hit 0.0% —
2064 KP13_02020 putative amino acid/amine transport AlphaFold + ColabFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
0.649 No Hit 0.0% —
2065 KP13_01774 hypothetical protein AlphaFold + ColabFold – – 0.649 No Hit 0.0% —
2066 KP13_00633 Protein rdoA rdoA AlphaFold + ColabFold
2.7.11.1
GO:0006468The process of introducing a phosphate group on to a protein. GO:0004674Catalysis of the reactions: ATP + protein serine = ADP + protein serine phosphate, and ATP + protein threonine = ADP + protein threonine phosphate. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. +36 total
0.649 No Hit 0.0% —
2067 KP13_06160 hypothetical protein AlphaFold + ColabFold – – 0.648 No Hit 0.0% —
2068 KP13_05471 TenA family transcription regulator AlphaFold + ColabFold
3.5.99.2
GO:0050334Catalysis of the reaction: H2O + thiamine = 4-amino-5-hydroxymethyl-2-methylpyrimidine + 5-(2-hydroxyethyl)-4-methylthiazole + H+. GO:0006772The chemical reactions and pathways involving thiamine (vitamin B1), a water soluble vitamin present in fresh vegetables and meats, especially liver. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. +25 total
0.648 No Hit 0.0% —
2069 KP13_05410 CTP pyrophosphohydrolase nudG AlphaFold + ColabFold –
GO:0006281The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. GO:0016787Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc.
0.648 No Hit 0.0% —
2070 KP13_04751 Adenosylhomocysteinase ahcY AlphaFold + ColabFold –
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0004013Catalysis of the reaction: S-adenosyl-L-homocysteine + H2O = adenosine + L-homocysteine. GO:0006730The chemical reactions and pathways involving the transfer of one-carbon units in various oxidation states. +14 total
0.648 Hit 33.0% 6.62e-40
2071 KP13_03645 Putative arabinogalactan oligomer transport system permease protein ganQ ganQ AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. +25 total
0.648 No Hit 0.0% —
2072 KP13_02637 hypothetical protein AlphaFold + ColabFold – – 0.648 No Hit 0.0% —
2073 KP13_00130 putative peroxidase-related protein AlphaFold + ColabFold –
GO:0051920Catalysis of the reaction: [protein]-dithol + ROOH = [protein]-disulfide + H2O + ROH.
0.648 No Hit 0.0% —
2074 KP13_04665 D-methionine-binding lipoprotein metQ AlphaFold + ColabFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
0.647 No Hit 0.0% —
2075 KP13_04661 hypothetical protein AlphaFold + ColabFold – – 0.647 Hit 44.4% 2.52e-95
Page of 208 · 5192 total proteins