Proteins

Genome: KpKP13

Description: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence

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5192 / 5842 proteins Structure: AlphaFold

Scoring formula None

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Structure: AlphaFold ×
# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
2126 KP13_00649 sn-glycerol-3-phosphate transport system permease protein ugpE ugpE AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
0.638 No Hit 0.0% —
2127 KP13_31558 Protein bax bax AlphaFold + ColabFold –
GO:0004040Catalysis of the reaction: a monocarboxylic acid amide + H2O = a monocarboxylate + NH4+.
0.637 No Hit 0.0% —
2128 KP13_04603 putative cysteine dioxygenase type I AlphaFold + ColabFold
1.13.11.-
GO:0016702Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from one donor, and two oxygen atoms is incorporated into a donor. GO:0005506Binding to an iron (Fe) ion. GO:0008198Binding to a ferrous iron ion, Fe(II).
0.637 No Hit 0.0% —
2129 KP13_03102 hypothetical protein AlphaFold + ColabFold – – 0.637 No Hit 0.0% —
2130 KP13_01129 hypothetical protein AlphaFold + ColabFold
2.7.1.217
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016301Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule.
0.637 No Hit 0.0% —
2131 KP13_00919 hypothetical protein AlphaFold + ColabFold – – 0.637 No Hit 0.0% —
2132 KP13_00595 putative rhamnose ABC transporter, ATP-binding protein AlphaFold + ColabFold –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
0.637 Hit 40.4% 6.23e-11
2133 KP13_31509 L-2,4-diaminobutyrate decarboxylase ddc AlphaFold + ColabFold –
GO:0030170Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0016830Catalysis of the cleavage of C-C bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. +36 total
0.636 Hit 49.0% 1.76e-23
2134 KP13_05489 putative esterase AlphaFold + ColabFold
3.1.-.-
GO:0016787Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc.
0.636 No Hit 0.0% —
2135 KP13_04549 NAD-dependent malic enzyme sfcA AlphaFold + ColabFold
1.1.1.38
GO:0051287Binding to nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD+, or the reduced form, NADH. GO:0004470Catalysis of the oxidative decarboxylation of malate with the concomitant production of pyruvate. GO:0004471Catalysis of the reaction: (S)-malate + NAD+ = pyruvate + CO2 + NADH. +47 total
0.636 Hit 48.6% 9.06e-81
2136 KP13_04153 hypothetical protein AlphaFold + ColabFold – – 0.636 No Hit 0.0% —
2137 KP13_03168 Ribitol 2-dehydrogenase rbtD AlphaFold + ColabFold –
GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
0.636 Hit 51.1% 1.76e-06
2138 KP13_02806 Adenylate cyclase domain-containing protein AlphaFold + ColabFold –
GO:0050355Catalysis of the reaction: H2O + inorganic triphosphate = diphosphate + phosphate. GO:0046872Binding to a metal ion.
0.636 No Hit 0.0% —
2139 KP13_02453 hypothetical protein AlphaFold + ColabFold – – 0.636 No Hit 0.0% —
2140 KP13_02301 Propanediol utilization protein pduV pduV AlphaFold + ColabFold –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0006576The chemical reactions and pathways occurring at the level of individual cells involving any of a group of naturally occurring, biologically active amines, such as norepinephrine, histamine, and serotonin, many of which act as neurotransmitters.
0.636 No Hit 0.0% —
2141 KP13_04705 hypothetical protein AlphaFold + ColabFold – – 0.635 No Hit 0.0% —
2142 KP13_03444 putative transcriptional regulator, GntR family AlphaFold + ColabFold –
GO:0030170Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0009058A cellular process consisting of the biochemical pathways by which a living organism synthesizes chemical substances. This typically represents the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. +36 total
0.635 Hit 23.9% 1.11e-21
2143 KP13_01719 ATP-dependent DNA helicase recQ recQ AlphaFold + ColabFold
5.6.2.4
GO:0044237OBSOLETE. The chemical reactions and pathways by which individual cells transform chemical substances. GO:0004386Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the unwinding of a DNA or RNA helix. GO:0006260The cellular metabolic process in which a cell duplicates one or more molecules of DNA. DNA replication begins when specific sequences, known as origins of replication, are recognized and bound by the origin recognition complex, and ends when the original DNA molecule has been completely duplicated and the copies topologically separated. The unit of replication usually corresponds to the genome of the cell, an organelle, or a virus. The template for replication can either be an existing DNA molecule or RNA. +1518 total
0.635 Hit 55.1% 7.66e-13
2144 KP13_00857 Penicillin-binding protein 1C pbpC AlphaFold + ColabFold
2.4.99.28
GO:0009252The chemical reactions and pathways resulting in the formation of peptidoglycans, any of a class of glycoconjugates found in bacterial cell walls and consisting of long glycan strands of alternating residues of beta-(1,4) linked N-acetylglucosamine and N-acetylmuramic acid, cross-linked by short peptides. GO:0008658Binding to penicillin, an antibiotic that contains the condensed beta-lactamthiazolidine ring system. GO:0008955Catalysis of the reaction: [GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n)-di-trans,octa-cis-undecaprenyl diphosphate + beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate = [GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)](n+1)-di-trans-octa-cis-undecaprenyl diphosphate + di-trans,octa-cis-undecaprenyl diphosphate + H+. +36 total
0.635 No Hit 0.0% —
2145 KP13_05488 AraC family transcriptional regulator AlphaFold + ColabFold –
GO:0043565Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
0.634 No Hit 0.0% —
2146 KP13_05479 Guanine deaminase AlphaFold + ColabFold
3.5.4.3
GO:0008270Binding to a zinc ion (Zn). GO:0016787Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. GO:0008892Catalysis of the reaction: guanine + H2O + H+ = xanthine + NH4+. +36 total
0.634 Hit 37.3% 4.05e-25
2147 KP13_04110 Carboxymuconolactone decarboxylase domain-containing protein AlphaFold + ColabFold –
GO:0051920Catalysis of the reaction: [protein]-dithol + ROOH = [protein]-disulfide + H2O + ROH.
0.634 No Hit 0.0% —
2148 KP13_04013 hypothetical protein AlphaFold + ColabFold – – 0.634 No Hit 0.0% —
2149 KP13_02091 Multidrug resistance protein mdtG mdtG AlphaFold + ColabFold –
GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
0.634 No Hit 0.0% —
2150 KP13_01210 Xylose isomerase AlphaFold + ColabFold
5.3.1.5
GO:0005975The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. GO:0009045Catalysis of the reaction: alpha-D-xylose = alpha-D-xylulofuranose. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. +25 total
0.634 No Hit 0.0% —
Page of 208 · 5192 total proteins