Proteins

Genome: KpKP13

Description: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence

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5192 / 5842 proteins Structure: AlphaFold

Scoring formula None

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Structure: AlphaFold ×
# Protein Description Gene Structure EC GO Metabolism Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
2451 KP13_02429 Protein grpE grpE AlphaFold + ColabFold –
GO:0000774Binds to and stimulates the hydrolysis and exchange of adenyl nucleotides by other proteins. GO:0051087Binding to a chaperone protein, a class of proteins that bind to nascent or unfolded polypeptides and ensure correct folding or transport. GO:0042803Binding to an identical protein to form a homodimer. +36 total
No map 0.579 Hit 35.8% 4.16e-16
2452 KP13_01875 hypothetical protein AlphaFold + ColabFold – – No map 0.579 No Hit 0.0% —
2453 KP13_00710 Siroheme synthase 2 cysG2 AlphaFold + ColabFold –
GO:0004851Catalysis of the reaction: uroporphyrinogen III + 2 S-adenosyl-L-methionine = precorrin-2 + 2 S-adenosyl-L-homocysteine + H+. GO:0051266Catalysis of the reaction: siroheme + 2 H+ = Fe(2+) + sirohydrochlorin. GO:0008168Catalysis of the transfer of a methyl group to an acceptor molecule. +58 total
No map 0.579 No Hit 0.0% —
2454 KP13_00604 AzlC family protein AlphaFold + ColabFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:1903785The directed movement of L-valine across a membrane.
No map 0.579 No Hit 0.0% —
2455 KP13_00365 Endoribonuclease L-PSP/chorismate mutase-like domain-containing protein AlphaFold + ColabFold –
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0019239Catalysis of the removal of an amino group from a substrate, producing a substituted or nonsubstituted ammonia (NH4+/NH2R).
No map 0.579 Hit 43.2% 1.75e-14
2456 KP13_06734 conjugal transfer TrbF-like protein trbF AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
No map 0.578 No Hit 0.0% —
2457 KP13_05467 Diaminobutyrate--2-oxoglutarate aminotransferase dat AlphaFold + ColabFold –
GO:0030170Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. GO:0008483Catalysis of the transfer of an amino group to an acceptor, usually a 2-oxo acid. GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. +14 total
No map 0.578 Hit 29.7% 1.38e-39
2458 KP13_03085 F-type conjugal transfer protein TraK AlphaFold + ColabFold – – No map 0.578 No Hit 0.0% —
2459 KP13_02204 hypothetical protein AlphaFold + ColabFold –
GO:0051920Catalysis of the reaction: [protein]-dithol + ROOH = [protein]-disulfide + H2O + ROH.
No map 0.578 No Hit 0.0% —
2460 KP13_01739 3-octaprenyl-4-hydroxybenzoate carboxy-lyase ubiD AlphaFold + ColabFold
4.1.1.98
GO:0016831Catalysis of the nonhydrolytic addition or removal of a carboxyl group to or from a compound. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0008694Catalysis of the reaction: a 4-hydroxy-3-(all-trans-polyprenyl)benzoate + H+ = a 2-(all-trans-polyprenyl)phenol + CO2. +36 total
No map 0.578 No Hit 0.0% —
2461 KP13_00777 Large-conductance mechanosensitive channel mscL AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0034220A process in which a monoatomic ion is transported across a membrane. Monatomic ions (also called simple ions) are ions consisting of exactly one atom. GO:0008381Enables the transmembrane transfer of an monoatomic ion by a channel that opens in response to a mechanical stress. +14 total
No map 0.578 No Hit 0.0% —
2462 KP13_00553 morphology and auto-aggregation control protein oxyR AlphaFold + ColabFold –
GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0032993A macromolecular complex containing both protein and DNA molecules. +14 total
No map 0.578 No Hit 0.0% —
2463 KP13_03045 hypothetical protein AlphaFold + ColabFold – – No map 0.577 No Hit 0.0% —
2464 KP13_02481 2-dehydro-3-deoxy-6-phosphogalactonate aldolase AlphaFold + ColabFold –
GO:0016829Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring.
No map 0.577 No Hit 0.0% —
2465 KP13_00883 Helix-turn-helix type 3 protein AlphaFold + ColabFold –
GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
No map 0.577 No Hit 0.0% —
2466 KP13_32154 ATP-dependent Clp protease proteolytic subunit ClpP clpP AlphaFold + ColabFold
3.4.21.92
GO:0006508The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds. GO:0004176Catalysis of the hydrolysis of peptide bonds, driven by ATP hydrolysis. GO:0004252Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). +47 total
No map 0.576 Hit 56.0% 3.74e-64
2467 KP13_05642 hypothetical protein AlphaFold + ColabFold – – No map 0.576 No Hit 0.0% —
2468 KP13_05238 Oxidoreductase, 2OG-Fe(II) oxygenase family protein AlphaFold + ColabFold
1.13.12.19 1.14.20.7
GO:0102276Catalysis of the reaction: 2-oxoglutarate(2-) + O2 + 2 H+ = ethene + 3 carbon dioxide + H2O. GO:0046872Binding to a metal ion. GO:0009693The chemical reactions and pathways resulting in the formation of ethylene (C2-H4, ethene), a simple hydrocarbon gas that can function in plants as a growth regulator.
No map 0.576 No Hit 0.0% —
2469 KP13_04154 putative protein psiA psiA AlphaFold + ColabFold – – No map 0.576 No Hit 0.0% —
2470 KP13_01642 L-arabinose-binding periplasmic protein araF AlphaFold + ColabFold –
GO:0042882The process in which L-arabinose, the L-enantiomer of arabinose, is transported across a lipid bilayer, from one side of a membrane to the other. GO:0030288The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin peptidoglycan layer (PGL), also referred to as a thin cell wall. GO:0030246Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates.
No map 0.576 No Hit 0.0% —
2471 KP13_04161 DNA-binding protein H-NS hns AlphaFold + ColabFold –
GO:0030527The action of a molecule that contributes to the structural integrity of chromatin. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). +811 total
No map 0.575 No Hit 0.0% —
2472 KP13_03716 hypothetical protein AlphaFold + ColabFold – – No map 0.575 No Hit 0.0% —
2473 KP13_01705 Uroporphyrinogen-III synthase hemD AlphaFold + ColabFold
4.2.1.75
GO:0006780The chemical reactions and pathways resulting in the formation of uroporphyrinogen III. GO:0033014The chemical reactions and pathways leading to the formation of tetrapyrroles, natural pigments containing four pyrrole rings joined by one-carbon units linking position 2 of one pyrrole ring to position 5 of the next. GO:0004852Catalysis of the reaction: hydroxymethylbilane = H2O + uroporphyrinogen III. +14 total
No map 0.575 No Hit 0.0% —
2474 KP13_01540 putative transglutaminase AlphaFold + ColabFold – – No map 0.575 No Hit 0.0% —
2475 KP13_01300 hypothetical protein AlphaFold + ColabFold – – No map 0.575 No Hit 0.0% —
Page of 208 · 5192 total proteins