Proteins

Genome: NC_002516.2

Description: Pseudomonas aeruginosa PAO1, complete genome

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Applied filters EC Number: 6.3.4.2

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EC Number: 6.3.4.2 ×
# Protein Description Gene Structure EC GO Metabolism Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
1 PA4376 nicotinate phosphoribosyltransferase pncB2, PA4376 Experimental + AlphaFold DB model
6.3.4.21
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0004516Catalysis of the reaction: nicotinate + 5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O = nicotinate beta-D-ribonucleotide + ADP + phosphate + diphosphate. GO:0034355The chemical reactions and pathways resulting in the formation of nicotinamide-adenine dinucleotide (NAD+) from vitamin B3 derivatives (including nicotinic acid (NA) and nicotinamide (NAM)), beta-nicotinamide D-ribonucleotide (NMN), nicotinamide riboside (NR) or nicotinate riboside (NAR), without de novo synthesis. +14 total
No map 0.902 No Hit N/A —
2 PA0976 7-cyano-7-deazaguanine synthase queC, PA0976 AlphaFold DB model
6.3.4.20
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016879Catalysis of the joining of two molecules, or two groups within a single molecule, via a carbon-nitrogen bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate. GO:0008270Binding to a zinc ion (Zn). +14 total
No map 0.715 No Hit N/A —
3 PA4919 nicotinate phosphoribosyltransferase PA4919, pncB1 AlphaFold DB model
6.3.4.21
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0004516Catalysis of the reaction: nicotinate + 5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O = nicotinate beta-D-ribonucleotide + ADP + phosphate + diphosphate. GO:0034355The chemical reactions and pathways resulting in the formation of nicotinamide-adenine dinucleotide (NAD+) from vitamin B3 derivatives (including nicotinic acid (NA) and nicotinamide (NAM)), beta-nicotinamide D-ribonucleotide (NMN), nicotinamide riboside (NR) or nicotinate riboside (NAR), without de novo synthesis. +14 total
No map 0.638 No Hit N/A —
4 PA3637 CTP synthetase pyrG, PA3637 AlphaFold DB model
6.3.4.2
GO:0097268A filamentous, membrane-less subcellular structure composed primarily of polymerized metabolic enzymes, most notably cytidine triphosphate synthase (CTPS). Cytoophidia are evolutionarily conserved structures found across archaea, bacteria, and eukaryotes. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. +811 total
No map 0.578 Hit 59.1% 1.31e-42
Page 1 of 1 · 4 total proteins