Proteins

Genome: NC_002516.2

Description: Pseudomonas aeruginosa PAO1, complete genome

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5572 / 5572 proteins

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# Protein Description Gene Structure EC GO Metabolism Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
2926 PA5522 glutamine synthetase PA5522 AlphaFold DB model –
GO:0004356Catalysis of the reaction: ATP + L-glutamate + NH4+ = ADP + H+ + L-glutamine + phosphate. GO:0006542OBSOLETE. The chemical reactions and pathways resulting in the formation of glutamine, 2-amino-4-carbamoylbutanoic acid. GO:0006598The chemical reactions and pathways resulting in the breakdown of polyamines, any organic compound containing two or more amino groups. +25 total
No map 0.722 Hit 26.0% 1.22e-18
2927 PA4446 AlgW protein algW, mucD_2, PA4446 Experimental + AlphaFold DB model –
GO:0008233Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid. GO:0004252Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). GO:0006508The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds. +14 total
No map 0.722 Hit 37.4% 1.72e-19
2928 PA4275 transcription antitermination protein NusG nusG, PA4275 AlphaFold DB model –
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0006354The extension of an RNA molecule after transcription initiation and promoter clearance at a DNA-dependent RNA polymerase promoter by the addition of ribonucleotides catalyzed by an RNA polymerase. GO:0006353The completion of transcription: the RNA polymerase pauses, the RNA-DNA hybrid dissociates, followed by the release of the RNA polymerase from its DNA template. +47 total
No map 0.722 No Hit N/A —
2929 PA4272 50S ribosomal protein L10 rplJ, PA4272 AlphaFold DB model –
GO:0022625The large subunit of a ribosome located in the cytosol. GO:0070180Binding to large ribosomal subunit RNA (LSU rRNA), a constituent of the large ribosomal subunit. In S. cerevisiae, this is the 25S rRNA. GO:0003735The action of a molecule that contributes to the structural integrity of the ribosome. +25 total
No map 0.722 No Hit N/A —
2930 PA4163 amidase PA4163 Experimental + AlphaFold DB model –
GO:0046872Binding to a metal ion.
No map 0.722 Hit 30.3% 2.47e-21
2931 PA3794 hypothetical protein PA3794 AlphaFold DB model – – No map 0.722 No Hit N/A —
2932 PA2655 hypothetical protein PA2655 AlphaFold DB model – – No map 0.722 No Hit N/A —
2933 PA2468 ECF sigma factor FoxI PA2468, foxI AlphaFold DB model –
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0016987Sigma factors act as the promoter specificity subunit of eubacterial and plant plastid multisubunit RNA polymerases, whose core subunit composition is often described as alpha(2)-beta-beta-prime. Although sigma does not bind DNA on its own, when combined with the core to form the holoenzyme, the sigma factor binds specifically to promoter elements. The sigma subunit is released once elongation begins. +47 total
No map 0.722 No Hit N/A —
2934 PA2355 FMNH2-dependent monooxygenase PA2355 AlphaFold DB model –
GO:0008470Catalysis of the reaction: 3-methylbutanoyl-CoA + H+ + oxidized [electron-transfer flavoprotein] = 3-methyl-(2E)-butenoyl-CoA + reduced [electron-transfer flavoprotein]. GO:0050660Binding to FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2. GO:0004497Catalysis of the incorporation of one atom of molecular oxygen (O2) into the substrate and the reduction of the other atom of O2 to water. +25 total
No map 0.722 Hit 25.3% 1.13e-13
2935 PA2254 paerucumarin biosynthesis protein PvcA PA2254, pvcA Experimental + AlphaFold DB model
4.1.99.24
GO:0016829Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring.
No map 0.722 No Hit N/A —
2936 PA1727 signaling protein PA1727, mucR Experimental + AlphaFold DB model
2.7.7.65 3.1.4.52
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0071111Catalysis of the reaction: cyclic di-3',5'-guanylate + H2O = 5'-phosphoguanylyl(3'->5')guanosine + H+. GO:0052621Catalysis of the reaction: 2 GTP = cyclic di-3',5'-guanylate + 2 diphosphate + 2 H+. +25 total
No map 0.722 No Hit N/A —
2937 PA5372 choline dehydrogenase betA, PA5372 AlphaFold DB model
1.1.99.1 1.2.1.8
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0008802Catalysis of the reaction: betaine aldehyde + NAD+ + H2O = betaine + NADH + H+. GO:0008812Catalysis of the reaction: A + choline = AH(2) + betaine aldehyde. +36 total
No map 0.721 Hit 49.7% 4.80e-174
2938 PA4797 transposase PA4797 AlphaFold DB model –
GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0004803Catalysis of the transposition of transposable elements or transposons. Transposases are involved in recombination required for transposition and are site-specific for the transposon/transposable element. GO:0006313A type of transposition in which a transposable element (transposon) is moved to another part of a genome, either by a cut-and-paste mechanism or a replicative mechanism.
No map 0.721 No Hit N/A —
2939 PA4547 two-component response regulator PilR pilR, PA4547 AlphaFold DB model –
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0032993A macromolecular complex containing both protein and DNA molecules. GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. +912 total
No map 0.721 No Hit N/A —
2940 PA4416 UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D- alanine ligase murF, PA4416 Experimental + AlphaFold DB model
6.3.2.10
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0046872Binding to a metal ion. +811 total
No map 0.721 No Hit N/A —
2941 PA4107 hypothetical protein PA4107 AlphaFold DB model –
GO:0005509Binding to a calcium ion (Ca2+). GO:0071277Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a calcium ion stimulus. GO:0006874A homeostatic process involved in the maintenance of a steady state level of calcium ions within a cell.
No map 0.721 No Hit N/A —
2942 PA3993 transposase PA4797 AlphaFold DB model –
GO:0004803Catalysis of the transposition of transposable elements or transposons. Transposases are involved in recombination required for transposition and are site-specific for the transposon/transposable element. GO:0006313A type of transposition in which a transposable element (transposon) is moved to another part of a genome, either by a cut-and-paste mechanism or a replicative mechanism. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
No map 0.721 No Hit N/A —
2943 PA3440 hypothetical protein PA3440 AlphaFold DB model – – No map 0.721 No Hit N/A —
2944 PA3434 transposase PA4797 AlphaFold DB model –
GO:0004803Catalysis of the transposition of transposable elements or transposons. Transposases are involved in recombination required for transposition and are site-specific for the transposon/transposable element. GO:0006313A type of transposition in which a transposable element (transposon) is moved to another part of a genome, either by a cut-and-paste mechanism or a replicative mechanism. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
No map 0.721 No Hit N/A —
2945 PA2833 hypothetical protein PA2833 AlphaFold DB model – – No map 0.721 No Hit N/A —
2946 PA2690 transposase PA4797 AlphaFold DB model –
GO:0004803Catalysis of the transposition of transposable elements or transposons. Transposases are involved in recombination required for transposition and are site-specific for the transposon/transposable element. GO:0006313A type of transposition in which a transposable element (transposon) is moved to another part of a genome, either by a cut-and-paste mechanism or a replicative mechanism. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
No map 0.721 No Hit N/A —
2947 PA2319 transposase PA4797 AlphaFold DB model –
GO:0004803Catalysis of the transposition of transposable elements or transposons. Transposases are involved in recombination required for transposition and are site-specific for the transposon/transposable element. GO:0006313A type of transposition in which a transposable element (transposon) is moved to another part of a genome, either by a cut-and-paste mechanism or a replicative mechanism. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
No map 0.721 No Hit N/A —
2948 PA1303 signal peptidase PA1303 AlphaFold DB model
3.4.21.89
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0008233Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid. GO:0004252Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). +912 total
No map 0.721 Hit 28.7% 2.02e-12
2949 PA0979 hypothetical protein PA0980, PA0979 AlphaFold DB model –
GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0004803Catalysis of the transposition of transposable elements or transposons. Transposases are involved in recombination required for transposition and are site-specific for the transposon/transposable element. GO:0006313A type of transposition in which a transposable element (transposon) is moved to another part of a genome, either by a cut-and-paste mechanism or a replicative mechanism.
No map 0.721 No Hit N/A —
2950 PA0745 enoyl-CoA hydratase PA0745 Experimental + AlphaFold DB model –
GO:0016836Catalysis of the cleavage of a carbon-oxygen bond by elimination of water. GO:0006635A fatty acid oxidation process that results in the complete oxidation of a long-chain fatty acid. Fatty acid beta-oxidation begins with the addition of coenzyme A to a fatty acid, and occurs by successive cycles of reactions during each of which the fatty acid is shortened by a two-carbon fragment removed as acetyl coenzyme A; the cycle continues until only two or three carbons remain (as acetyl-CoA or propionyl-CoA respectively). GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic.
No map 0.721 Hit 36.6% 2.55e-25
Page of 223 · 5572 total proteins