Proteins

Genome: NC_002516.2

Description: Pseudomonas aeruginosa PAO1, complete genome

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5572 proteins

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Rows
# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
5551 PA2805 hypothetical protein PA2805 AlphaFold – – No pocket No Hit N/A —
5552 PA3742 50S ribosomal protein L19 rplS, PA3742 AlphaFold –
GO:0022625The large subunit of a ribosome located in the cytosol. GO:0003735The action of a molecule that contributes to the structural integrity of the ribosome. GO:0006412The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome. +14 total
No pocket No Hit N/A —
5553 PA0258 hypothetical protein PA0258 AlphaFold – – No pocket No Hit N/A —
5554 PA2142a hypothetical protein ColabFold – – No pocket No Hit N/A —
5555 PA2756 hypothetical protein PA2756 AlphaFold – – No pocket No Hit N/A —
5556 PA3758 N-acetylglucosamine-6-phosphate deacetylase PA3758 AlphaFold –
GO:0046872Binding to a metal ion. GO:0008448Catalysis of the reaction: H2O + N-acetyl-D-glucosamine 6-phosphate = acetate + D-glucosamine 6-phosphate. GO:0006046The chemical reactions and pathways resulting in the breakdown of N-acetylglucosamine. The D isomer is a common structural unit of glycoproteins in plants, bacteria and animals; it is often the terminal sugar of an oligosaccharide group of a glycoprotein. +36 total
No pocket Hit 36.2% 5.18e-11
5557 PA5157 transcriptional regulator PA5157 AlphaFold –
GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. +14 total
No pocket No Hit N/A —
5558 PA4306 type IVb pilin Flp PA4306, flp AlphaFold – – No pocket No Hit N/A —
5559 PA4795 hypothetical protein PA4795 AlphaFold – – No pocket No Hit N/A —
5560 PA2446 glycine cleavage system protein H gcvH2 UnavailableNo structure available — sequence may exceed the prediction length limit –
GO:0005960A protein complex that catalyzes the reversible oxidation of glycine. In E. coli, it has four components: dihydrolipoamide dehydrogenase, glycine dehydrogenase (decarboxylating), lipoyl-GcvH-protein and aminomethyltransferase, also known as L, P, H, and T. GO:0019464The chemical reactions and pathways resulting in the breakdown of glycine by oxidative cleavage to carbon dioxide, ammonia, and a methylene group, mediated by enzymes of the glycine cleavage complex.
No structure No structure No structure No structure
5561 PA4578 hypothetical protein PA4578 AlphaFold – – No pocket No Hit N/A —
5562 PA0032a DOPA 4,5-dioxygenase ColabFold – – No pocket No Hit N/A —
5563 PA0442 hypothetical protein PA0442 AlphaFold – – No pocket No Hit N/A —
5564 PA4254 30S ribosomal protein S17 rpsQ, PA4254 AlphaFold –
GO:0022627The small subunit of a ribosome located in the cytosol. GO:0019843Binding to a ribosomal RNA. GO:0003735The action of a molecule that contributes to the structural integrity of the ribosome. +25 total
No pocket Hit 37.3% 5.35e-07
5565 PA5229 hypothetical protein PA5229 AlphaFold –
GO:0005634A membrane-bounded organelle of eukaryotic cells in which chromosomes are housed and replicated. In most cells, the nucleus contains all of the cell's chromosomes except the organellar chromosomes, and is the site of RNA synthesis and processing. In some species, or in specialized cell types, RNA metabolism or DNA replication may be absent.
No pocket Hit 41.5% 4.53e-40
5566 PA2367 hypothetical protein PA2367 AlphaFold – – No pocket No Hit N/A —
5567 PA4336 hypothetical protein PA4336 AlphaFold –
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0019172Catalysis of the reaction: methylglyoxal + H2O = D-lactate. GO:0106044The removal of a sugar or dicarbonyl from a glycated guanine.
No pocket No Hit N/A —
5568 PA5142 imidazole glycerol phosphate synthase subunit HisH PA5142, hisH1 AlphaFold
4.3.2.10 3.5.1.2
GO:0009382Complex that possesses imidazoleglycerol-phosphate synthase activity. GO:0004359Catalysis of the reaction: L-glutamine + H2O = L-glutamate + NH4+. GO:0000107Catalysis of the reaction: phosphoribulosylformimino-AICAR-P + L-glutamine = D-erythro-imidazole-glycerol-phosphate + aminoimidazole carboxamide ribonucleotide + L-glutamate + 2 H+. +36 total
No pocket No Hit N/A —
5569 PA3347 hypothetical protein PA3347 AlphaFold –
GO:0043856The function of binding to an anti-sigma factor and stopping, preventing or reducing the rate of its activity.
No pocket No Hit N/A —
5570 PA3085 hypothetical protein PA3085 AlphaFold – – No pocket No Hit N/A —
5571 PA5214 glycine cleavage system protein H gcvH1 ColabFold –
GO:0005960A protein complex that catalyzes the reversible oxidation of glycine. In E. coli, it has four components: dihydrolipoamide dehydrogenase, glycine dehydrogenase (decarboxylating), lipoyl-GcvH-protein and aminomethyltransferase, also known as L, P, H, and T. GO:0019464The chemical reactions and pathways resulting in the breakdown of glycine by oxidative cleavage to carbon dioxide, ammonia, and a methylene group, mediated by enzymes of the glycine cleavage complex.
No pocket Hit 55.1% 2.21e-26
5572 PA3928 hypothetical protein PA3928 AlphaFold – – No pocket No Hit N/A —
Page of 223 · 5572 total proteins