Proteins

Genome: NC_002516.2

Description: Pseudomonas aeruginosa PAO1, complete genome

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5572 / 5572 proteins

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# Protein Description Gene Structure EC GO Metabolism Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
2876 PA5389 CdhR family transcriptional regulator cdhR, PA5389 AlphaFold –
GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0043565Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. GO:0009896Any process that activates or increases the frequency, rate or extent of the chemical reactions and pathways resulting in the breakdown of substances. +14 total
No map 0.728 No Hit N/A —
2877 PA5325 hypothetical protein PA5325 AlphaFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0071396Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a lipid stimulus. GO:0051872The chemical reactions and pathways resulting in the breakdown of sphingosine (sphing-4-enine), trans-D-erytho-2-amino-octadec-4-ene-1,3-diol, a long chain amino diol sphingoid base that occurs in most sphingolipids in animal tissues.
No map 0.728 No Hit N/A —
2878 PA4203 transcriptional regulator PA4203, nmoR AlphaFold –
GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0000976Binding to a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
No map 0.728 No Hit N/A —
2879 PA2990 phosphodiesterase PA2990 AlphaFold –
GO:0047389Catalysis of the reaction: H2O + L-1-glycero-3-phosphocholine = glycerol-3-phosphate + choline. GO:0008889Catalysis of the reaction: a glycerophosphodiester + H2O = an alcohol + sn-glycerol 3-phosphate. GO:0047395Catalysis of the reaction: 1-(sn-glycero-3-phospho)-1D-myo-inositol + H2O = sn-glycerol 3-phosphate + myo-inositol + H+. +25 total
No map 0.728 Hit 45.5% 3.01e-06
2880 PA2616 thioredoxin reductase trxB1, PA2616 AlphaFold
1.8.1.9
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0004791Catalysis of the reaction: thioredoxin-dithiol + NADP+ = thioredoxin-disulfide + H+ + NADPH. GO:0045454Any process that maintains the redox environment of a cell or compartment within a cell. +25 total
No map 0.728 No Hit N/A —
2881 PA2497 transcriptional regulator PA2497 AlphaFold –
GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
No map 0.728 No Hit N/A —
2882 PA1124 deoxyguanosinetriphosphate triphosphohydrolase PA1124, dgt Experimental + AlphaFold
3.1.5.1
GO:0008832Catalysis of the reaction: dGTP + H2O = 2'-deoxyguanosine + 2 H+ + triphosphate. GO:0000287Binding to a magnesium (Mg) ion. GO:0006203The chemical reactions and pathways resulting in the breakdown of dGTP, guanosine triphosphate. +14 total
No map 0.728 No Hit N/A —
2883 PA0897 arginine N-succinyltransferase subunit beta PA0897, aruG AlphaFold
2.3.1.109
GO:0008791Catalysis of the reaction: succinyl-CoA + L-arginine = N2-succinyl-L-arginine + CoA + H+. GO:0009015Catalysis of the reaction: N(2)-succinyl-L-arginine + 2 H2O + 2 H+ = N(2)-succinyl-L-ornithine + CO2 + 2 NH4. GO:0006527The chemical reactions and pathways resulting in the breakdown of L-arginine. +14 total
No map 0.728 No Hit N/A —
2884 PA0772 DNA repair protein RecO recO, PA0772 AlphaFold –
GO:0043590The region of a bacterial cell to which the DNA is confined. GO:0006310Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Interchromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction. GO:0006302The repair of double-strand breaks in DNA via homologous and nonhomologous mechanisms to reform a continuous DNA helix. +14 total
No map 0.728 No Hit N/A —
2885 PA0692 hypothetical protein PA0692 AlphaFold –
GO:0098046A complex of proteins that permits the translocation of proteins across the outer membrane via a transmembrane pore, formed by a beta-barrel, into the extracellular milieu or directly into host cells; the secreted proteins contain all the information required for translocation of an effector molecule through the cell envelope. The type V secretion systems includes the autotransporters (type Va), the two-partner secretion system (type Vb) and the Oca family (type Vc). GO:0008320Enables the transfer of a protein from one side of a membrane to the other. GO:0046819The process in which proteins mediate their own secretion across the outer membrane through a beta-barrel pore structure formed by the C-terminal domain of the protein precursor. Following passage across the outer membrane, the mature protein is released from the pore by an autocatalytic activity. Proteins secreted by the Type V system are first translocated across the plasma membrane by the Sec pathway.
No map 0.728 No Hit N/A —
2886 PA5470 peptide chain release factor-like protein PA5470 AlphaFold –
GO:0003747Involved in catalyzing the release of a nascent polypeptide chain from a ribosome. GO:0046677Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of an antibiotic stimulus. An antibiotic is a chemical substance produced by a microorganism which has the capacity to inhibit the growth of or to kill other microorganisms. GO:0006415The process resulting in the release of a polypeptide chain from the ribosome, usually in response to a termination codon (UAA, UAG, or UGA in the universal genetic code).
No map 0.727 Hit 51.7% 8.03e-12
2887 PA4492 hypothetical protein PA4492 AlphaFold – – No map 0.727 No Hit N/A —
2888 PA4454 hypothetical protein PA4454 AlphaFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0120014Removes a phospholipid from a membrane or a monolayer lipid particle, transports it through the aqueous phase while protected in a hydrophobic pocket, and brings it to an acceptor membrane or lipid particle. GO:0120010The transport of phospholipids between membranes in which a phospholipid molecule is transported through an aqueous phase from the outer leaflet of a donor membrane to the outer leaflet of an acceptor membrane. +14 total
No map 0.727 No Hit N/A —
2889 PA2549 hypothetical protein PA2549 AlphaFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0071467Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pH stimulus. pH is a measure of the acidity or basicity of an aqueous solution. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
No map 0.727 No Hit N/A —
2890 PA2173 hypothetical protein PA2173 AlphaFold – – No map 0.727 No Hit N/A —
2891 PA1745 hypothetical protein PA1745 AlphaFold –
GO:0005515Binding to a protein.
No map 0.727 No Hit N/A —
2892 PA0759 hypothetical protein PA0759 AlphaFold –
GO:0016226The incorporation of iron and exogenous sulfur into a metallo-sulfur cluster.
No map 0.727 Hit 33.6% 3.38e-07
2893 PA0559 hypothetical protein PA0559 AlphaFold – – No map 0.727 No Hit N/A —
2894 PA0501 8-amino-7-oxononanoate synthase PA0501, bioF AlphaFold
2.3.1.47
GO:0008710Catalysis of the reaction: L-alanine + H+ + pimelyl-CoA = 8-amino-7-oxononanoate + CO2 + CoA. GO:0030170Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. GO:0009102The chemical reactions and pathways resulting in the formation of biotin, cis-tetrahydro-2-oxothieno(3,4-d)imidazoline-4-valeric acid. +36 total
No map 0.727 Hit 42.1% 2.35e-12
2895 PA0219 aldehyde dehydrogenase PA0219 AlphaFold –
GO:0004030Catalysis of the reaction: an aldehyde + NAD(P)+ + H2O = an acid + NAD(P)H + H+. GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. GO:0016620Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces NAD or NADP.
No map 0.727 Hit 46.4% 5.90e-07
2896 PA5507 hypothetical protein PA5507 AlphaFold –
GO:0016787Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc.
No map 0.726 No Hit N/A —
2897 PA4174 transcriptional regulator PA4174 AlphaFold –
GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0043565Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. GO:0006351The synthesis of an RNA transcript from a DNA template. +14 total
No map 0.726 No Hit N/A —
2898 PA3327 non-ribosomal peptide synthetase PA3327 AlphaFold –
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0031177Binding to phosphopantetheine, the vitamin pantetheine 4'-(dihydrogen phosphate). +69 total
No map 0.726 Hit 43.3% 1.64e-11
2899 PA2399 pyoverdine synthetase D PA2399, pvdD AlphaFold –
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. +69 total
No map 0.726 Hit 30.7% 1.66e-06
2900 PA2024 ring-cleaving dioxygenase PA2024 AlphaFold –
GO:0046686Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a cadmium (Cd) ion stimulus.
No map 0.726 No Hit N/A —
Page of 223 · 5572 total proteins