Proteins

Genome: NC_002516.2

Description: Pseudomonas aeruginosa PAO1, complete genome

Search, filter, and prioritize proteins.

Export view
5572 / 5572 proteins

Scoring formula None

Sorted by Druggability (descending)

Applied filters No active filters

Search query No active search

Rows per page 25

Rows
# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
4226 PA3753 hypothetical protein PA3753 AlphaFold –
GO:0016289Catalysis of the reaction: an acyl-CoA + H2O = a carboxylate + CoA + H+. GO:0009437The chemical reactions and pathways involving carnitine (hydroxy-trimethyl aminobutyric acid), a compound that participates in the transfer of acyl groups across the inner mitochondrial membrane.
0.569 Hit 23.8% 8.70e-09
4227 PA2374 hypothetical protein PA2374 AlphaFold – – 0.569 No Hit N/A —
4228 PA2117 hypothetical protein PA2117 AlphaFold – – 0.569 No Hit N/A —
4229 PA0469 hypothetical protein PA0469 AlphaFold – – 0.569 No Hit N/A —
4230 PA5563 chromosome partitioning protein Soj soj, PA5563 AlphaFold – – 0.568 No Hit N/A —
4231 PA4419 cell division protein FtsL ftsL, PA4419 AlphaFold –
GO:0032153The eventual plane of cell division (also known as cell cleavage or cytokinesis) in a dividing cell. In Eukaryotes, the cleavage apparatus, composed of septin structures and the actomyosin contractile ring, forms along this plane, and the mitotic, or meiotic, spindle is aligned perpendicular to the division plane. In bacteria, the cell division site is generally located at mid-cell and is the site at which the cytoskeletal structure, the Z-ring, assembles. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0043093A cytokinesis process that involves a set of conserved proteins including FtsZ, and results in the formation of two similarly sized and shaped cells. +25 total
0.568 No Hit N/A —
4232 PA3501 hypothetical protein PA3501 AlphaFold – – 0.568 No Hit N/A —
4233 PA3282 hypothetical protein PA3282 AlphaFold – – 0.568 No Hit N/A —
4234 PA1949 ribose operon repressor RbsR PA1949, rbsR AlphaFold –
GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0000976Binding to a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. +14 total
0.568 No Hit N/A —
4235 PA1932 hydroxylase molybdopterin-containing subunit PA1932 AlphaFold –
GO:0071949Binding to the oxidized form, FAD, of flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. GO:0016903Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. GO:0050660Binding to FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2. +14 total
0.568 No Hit N/A —
4236 PA2158 alcohol dehydrogenase PA2158 AlphaFold –
GO:0016616Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP. GO:0008270Binding to a zinc ion (Zn). GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.
0.567 Hit 39.0% 4.44e-09
4237 PA1366 hypothetical protein PA1366 AlphaFold
2.7.7.108
GO:0070733Catalysis of the reaction: ATP + protein = diphosphate + adenylyl-protein; mediates the addition of an adenylyl (adenosine 5'-monophosphate; AMP group) to L-serine, L-threonine, and L-tyrosine residues in target proteins. GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0051302Any process that modulates the frequency, rate or extent of the physical partitioning and separation of a cell into daughter cells.
0.567 No Hit N/A —
4238 PA0463 DNA-binding response regulator CreB PA0463, creB AlphaFold –
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0032993A macromolecular complex containing both protein and DNA molecules. GO:0000987Binding to a specific upstream regulatory DNA sequence (transcription factor recognition sequence or binding site, located in cis relative to the transcription start site (i.e., on the same strand of DNA) of a gene transcribed by some RNA polymerase. Cis-regulatory sites are often referred to as a sequence motifs, enhancers, or silencers. +710 total
0.567 No Hit N/A —
4239 PA0387 non-canonical purine NTP pyrophosphatase PA0387 AlphaFold
3.6.1.66
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0035870Catalysis of the reaction: dITP + H2O = dIMP + H+ + diphosphate. +912 total
0.567 Hit 29.3% 2.04e-12
4240 PA5046 malic enzyme PA5046 AlphaFold
1.1.1.40
GO:0004473Catalysis of the reaction: (S)-malate + NADP+ = pyruvate + CO2 + NADPH. GO:0046872Binding to a metal ion. GO:0051287Binding to nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD+, or the reduced form, NADH. +25 total
0.566 Hit 30.4% 6.49e-11
4241 PA5045 penicillin-binding protein 1A PA5045, mrcA, ponA Experimental + AlphaFold –
GO:0030288The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin peptidoglycan layer (PGL), also referred to as a thin cell wall. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0008658Binding to penicillin, an antibiotic that contains the condensed beta-lactamthiazolidine ring system. +710 total
0.566 No Hit N/A —
4242 PA4798 hypothetical protein PA4798 AlphaFold – – 0.566 No Hit N/A —
4243 PA4509 hypothetical protein PA4509 AlphaFold –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016787Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc.
0.566 No Hit N/A —
4244 PA3121 3-isopropylmalate dehydratase large subunit leuC, PA3121 AlphaFold
4.2.1.33
GO:0003861Catalysis of the reaction: (2R,3S)-3-isopropylmalate = (2S)-2-isopropylmalate. GO:0051539Binding to a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands. GO:0046872Binding to a metal ion. +14 total
0.566 Hit 32.2% 1.29e-09
4245 PA2115 transcriptional regulator PA2115 AlphaFold –
GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0000976Binding to a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
0.566 No Hit N/A —
4246 PA1816 DNA polymerase III subunit epsilon dnaQ, PA1816 AlphaFold
2.7.7.7
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0008408Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' end. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). +58 total
0.566 No Hit N/A —
4247 PA1423 biofilm dispersion protein bdlA, PA1423 AlphaFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0008276Catalysis of the transfer of a methyl group (CH3-) to a protein. GO:0004888Combining with an extracellular or intracellular signal and transmitting the signal from one side of the membrane to the other to initiate a change in cell activity or state as part of signal transduction. +36 total
0.566 No Hit N/A —
4248 PA1187 acyl-CoA dehydrogenase PA1187 AlphaFold –
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0003995Catalysis of the reaction: a 2,3-saturated acyl-CoA + H+ oxidized [electron-transfer flavoprotein] = a (2E)-enoyl-CoA + reduced [electron-transfer flavoprotein]. GO:0050660Binding to FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2. +25 total
0.566 Hit 48.7% 2.17e-124
4249 PA0735 hypothetical protein PA0735 AlphaFold – – 0.566 No Hit N/A —
4250 PA3279 phosphate-specific outer membrane porin OprP PA3279, oprP Experimental + AlphaFold –
GO:0009279A lipid bilayer that forms the outermost membrane of the cell envelope; enriched in polysaccharide and protein; the outer leaflet of the membrane contains specific lipopolysaccharide structures. GO:0046930A protein complex providing a discrete opening in a membrane that allows the passage of gases and/or liquids. GO:0015288Enables the transfer of substances, sized less than 1000 Da, from one side of a membrane to the other. The transmembrane portions of porins consist exclusively of beta-strands which form a beta-barrel. They are found in the outer membranes of Gram-negative bacteria, mitochondria, plastids and possibly acid-fast Gram-positive bacteria. +14 total
0.565 No Hit N/A —
Page of 223 · 5572 total proteins