Proteins

Genome: NC_002516.2

Description: Pseudomonas aeruginosa PAO1, complete genome

Search, filter, and prioritize proteins.

Export view
5425 / 5572 proteins Structure: AlphaFold

Scoring formula None

Sorted by Druggability (descending)

Applied filters Structure: AlphaFold

Search query No active search

Rows per page 25

Rows
Active criteria 1
Structure: AlphaFold DB model ×
# Protein Description Gene Structure EC GO Metabolism Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
26 PA1450 hypothetical protein PA1450 AlphaFold DB model – – No map 0.976 No Hit N/A —
27 PA1317 cytochrome o ubiquinol oxidase subunit II PA1317, cyoA AlphaFold DB model –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0098803Any protein complex that is part of a respiratory chain. GO:0005507Binding to a copper (Cu) ion. +69 total
No map 0.976 No Hit N/A —
28 PA0722 hypothetical protein PA0722 AlphaFold DB model – – No map 0.976 No Hit N/A —
29 PA5307 hypothetical protein PA5307 AlphaFold DB model – – No map 0.975 No Hit N/A —
30 PA4067 outer membrane protein OprG oprG, PA4067 Experimental + AlphaFold DB model –
GO:0044384The external membrane of Gram-negative bacteria or certain organelles such as mitochondria and chloroplasts; freely permeable to most ions and metabolites, occurring in a host cell. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0019867The external membrane of Gram-negative bacteria or certain organelles such as mitochondria and chloroplasts; freely permeable to most ions and metabolites. +14 total
No map 0.975 No Hit N/A —
31 PA3959 hypothetical protein PA3959 AlphaFold DB model – – No map 0.975 No Hit N/A —
32 PA3888 ABC transporter permease PA3888 AlphaFold DB model –
GO:0055052A complex for the transport of metabolites into the cell, consisting of 5 subunits: two ATP-binding subunits, two membrane spanning subunits, and one substrate-binding subunit. In organisms with two membranes, the substrate-binding protein moves freely in the periplasmic space and joins the other subunits only when bound with substrate. In organisms with only one membrane the substrate-binding protein is tethered to the cytoplasmic membrane and associated with the other subunits. Transport of the substrate across the membrane is driven by the hydrolysis of ATP. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:1902495A transmembrane protein complex which enables the transfer of a substance from one side of a membrane to the other. +69 total
No map 0.975 No Hit N/A —
33 PA2457 hypothetical protein PA2457 AlphaFold DB model – – No map 0.975 No Hit N/A —
34 PA5232 hypothetical protein PA5232 AlphaFold DB model –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
No map 0.974 No Hit N/A —
35 PA4933 hypothetical protein PA4933 AlphaFold DB model – – No map 0.974 No Hit N/A —
36 PA3109 hypothetical protein PA3109 AlphaFold DB model –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0009403The chemical reactions and pathways resulting in the formation of toxin, a poisonous compound (typically a protein) that is produced by cells or organisms and that can cause disease when introduced into the body or tissues of an organism. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
No map 0.974 No Hit N/A —
37 PA2996 Na(+)-translocating NADH-quinone reductase subunit D nqrD, PA2996 AlphaFold DB model
7.2.1.1
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0016655Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces a quinone or a similar acceptor molecule. GO:0006814The directed movement of sodium ions (Na+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. +14 total
No map 0.974 No Hit N/A —
38 PA2875 hypothetical protein PA2875 AlphaFold DB model –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.
No map 0.974 Hit 30.7% 8.83e-06
39 PA2339 binding-protein-dependent maltose/mannitol transport protein PA2339 AlphaFold DB model –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
No map 0.974 No Hit N/A —
40 PA5557 ATP synthase subunit delta atpH, PA5557 AlphaFold DB model –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0045259A proton-transporting two-sector ATPase complex that catalyzes the phosphorylation of ADP to ATP during oxidative phosphorylation. The complex comprises a membrane sector (F0) that carries out proton transport and a cytoplasmic compartment sector (F1) that catalyzes ATP synthesis by a rotational mechanism; the extramembrane sector (containing 3 a and 3 b subunits) is connected via the d-subunit to the membrane sector by several smaller subunits. Within this complex, the g and e subunits and the 9-12 c subunits rotate by consecutive 120 degree angles and perform parts of ATP synthesis. This movement is driven by the hydrogen ion electrochemical potential gradient. GO:0046933Enables the synthesis of ATP from ADP and phosphate by the transfer of protons from one side of a membrane to the other by a rotational mechanism driven by a gradient according to the reaction: ADP + phosphate + 5 H+(out) => ATP + H2O + 4 H+(in). +14 total
No map 0.973 Hit 27.7% 1.87e-13
41 PA3662 hypothetical protein PA3662 AlphaFold DB model – – No map 0.973 No Hit N/A —
42 PA3445 hypothetical protein PA3445 AlphaFold DB model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0042597The region between the inner (cytoplasmic) and outer membrane (Gram-negative Bacteria) or cytoplasmic membrane and cell wall (Fungi and Gram-positive Bacteria). GO:0042626Primary active transporter of a solute across a membrane, via the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of a substance across a membrane. The transport protein may be transiently phosphorylated (P-type transporters), or not (ABC-type transporters and other families of transporters). Primary active transport occurs up the solute's concentration gradient and is driven by a primary energy source.
No map 0.973 No Hit N/A —
43 PA1889 hypothetical protein PA1889 AlphaFold DB model – – No map 0.973 No Hit N/A —
44 PA1190 hypothetical protein PA1190 AlphaFold DB model –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0005262Enables the energy-independent facilitated diffusion of a calcium ion through a transmembrane aqueous pore or channel. GO:0030162Any process that modulates the frequency, rate or extent of the hydrolysis of a peptide bond or bonds within a protein. +14 total
No map 0.973 No Hit N/A —
45 PA0513 heme d1 biosynthesis protein NirG PA0513, nirG AlphaFold DB model
4.1.1.111
GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0016829Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring. GO:0006783The chemical reactions and pathways resulting in the formation of heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring, from less complex precursors. +14 total
No map 0.973 No Hit N/A —
46 PA0111 hypothetical protein PA0111 AlphaFold DB model – – No map 0.973 No Hit N/A —
47 PA4779 hypothetical protein PA4779 AlphaFold DB model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0015562Enables the transfer of a specific substance or related group of substances from the inside of the cell to the outside of the cell across a membrane. GO:0033228The directed movement of cysteine from inside of a cell, across the plasma membrane and into the extracellular region.
No map 0.972 No Hit N/A —
48 PA4491 hypothetical protein PA4491 AlphaFold DB model – – No map 0.972 No Hit N/A —
49 PA2288 hypothetical protein PA2288 AlphaFold DB model – – No map 0.972 No Hit N/A —
50 PA0674 hypothetical protein pigC, vreA, PA0674 AlphaFold DB model –
GO:0019867The external membrane of Gram-negative bacteria or certain organelles such as mitochondria and chloroplasts; freely permeable to most ions and metabolites. GO:0042597The region between the inner (cytoplasmic) and outer membrane (Gram-negative Bacteria) or cytoplasmic membrane and cell wall (Fungi and Gram-positive Bacteria). GO:0038023Receiving a signal and transmitting it in the cell to initiate a change in cell activity. A signal is a physical entity or change in state that is used to transfer information in order to trigger a response.
No map 0.972 No Hit N/A —
Page of 217 · 5425 total proteins