Proteins

Genome: NZ_AP023069.1

Description: Neisseria gonorrhoeae strain TUM19854 chromosome, complete genome

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3 proteins Structure: Experimental

Scoring formula None

Sorted by Druggability (descending)

Applied filters Structure: Experimental

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Structure: Has experimental PDB ×
# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
1 HT085_RS00030 leucine--tRNA ligase leuS Experimental + AlphaFold
6.1.1.4
GO:0004823Catalysis of the reaction: leucine + ATP + tRNA(Leu) = AMP + diphosphate + 2 H+ + Leu-tRNA(Leu). GO:0006429The process of coupling leucine to leucyl-tRNA, catalyzed by leucyl-tRNA synthetase. The leucyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of a leucine-accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification. GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. +25 total
No pocket Hit — —
2 HT085_RS00165 class II fructose-bisphosphate aldolase fda, fba Experimental + AlphaFold
4.1.2.13
GO:0004332Catalysis of the reaction: beta-D-fructose 1,6-bisphosphate = D-glyceraldehyde 3-phosphate + dihydroxyacetone phosphate. GO:0008270Binding to a zinc ion (Zn). GO:0006096The chemical reactions and pathways resulting in the breakdown of a carbohydrate into pyruvate, with the concomitant production of a small amount of ATP and the reduction of NAD(P) to NAD(P)H. Glycolysis begins with the metabolism of a carbohydrate to generate products that can enter the pathway and ends with the production of pyruvate. Pyruvate may be converted to acetyl-coenzyme A, ethanol, lactate, or other small molecules.
No pocket No Hit — —
3 HT085_RS00260 endonuclease domain-containing protein Experimental + AlphaFold – – No pocket No Hit — —
Page 1 of 1 · 3 total proteins