Proteins

Genome: NZ_AP023069.1

Description: Neisseria gonorrhoeae strain TUM19854 chromosome, complete genome

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# Protein Description Gene Structure EC GO Metabolism Druggability (P2Rank) P2RANK ligandability score for the best pocket in the experimental structure (0–1). Higher values indicate higher predicted ligandability. Available only for genomes analyzed with the curated pipeline. Druggability (FPocket) FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
1 HT085_RS00090 GAF domain-containing protein ytsP, msrC AlphaFold DB model
1.8.4.14
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0033745Catalysis of the reaction: [thioredoxin]-disulfide + L-methionine + H2O = L-methionine (R)-S-oxide + [thioredoxin]-dithiol.
No map — No pocket No Hit — —
2 HT085_RS00015 polyphosphate kinase 1 ppk, ppk1 AlphaFold DB model
2.7.4.1
GO:0008976Catalysis of the reaction: ATP + phosphate(n) = ADP + phosphate(n+1). GO:0009358A protein complex that possesses polyphosphate kinase activity. GO:0006799The chemical reactions and pathways resulting in the formation of a polyphosphate, the anion or salt of polyphosphoric acid. +25 total
No map — No pocket No Hit — —
3 HT085_RS00005 chromosomal replication initiator protein DnaA dnaA AlphaFold DB model –
GO:0006270The process in which DNA-dependent DNA replication is started; it begins when specific sequences, known as origins of replication, are recognized and bound by the origin recognition complex, followed by DNA unwinding. GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. GO:0003688Binding to a DNA replication origin, a unique DNA sequence of a replicon at which DNA replication is initiated and proceeds bidirectionally or unidirectionally. +69 total
No map — No pocket No Hit — —
4 HT085_RS00130 amino-acid N-acetyltransferase argA AlphaFold DB model
2.3.1.1
GO:0016747Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0006526The chemical reactions and pathways resulting in the formation of arginine, 2-amino-5-(carbamimidamido)pentanoic acid. +14 total
No map — No pocket No Hit — —
5 HT085_RS00215 oligoribonuclease orn AlphaFold DB model
3.1.-.-
GO:0003676Binding to a nucleic acid. GO:0000175Catalysis of the sequential cleavage of mononucleotides from a free 3' terminus of an RNA molecule. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. +14 total
No map — No pocket Hit — —
6 HT085_RS00200 glutamate-1-semialdehyde 2,1-aminomutase hemL AlphaFold DB model
5.4.3.8
GO:0008483Catalysis of the transfer of an amino group to an acceptor, usually a 2-oxo acid. GO:0030170Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. GO:0042286Catalysis of the reaction: (S)-4-amino-5-oxopentanoate = 5-aminolevulinate. +25 total
No map — No pocket Hit — —
7 HT085_RS00325 hypothetical protein AlphaFold DB model – – No map — No pocket No Hit — —
8 HT085_RS00160 factor H-binding protein ColabFold model – – No map — No pocket No Hit — —
9 HT085_RS00155 tRNA (adenosine(37)-N6)-threonylcarbamoyltransferase complex dimerization subunit type 1 TsaB tsaB, yeaZ AlphaFold DB model –
GO:0002949The attachment of a carbonyl group and a threonine to the amino group of the adenine residue immediately 3' of the anticodon, in tRNAs that decode ANN codons (where N is any base). GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
No map — No pocket No Hit — —
10 HT085_RS00230 acetyl-CoA carboxylase biotin carboxyl carrier protein accB AlphaFold DB model –
GO:0003989Catalysis of the reaction: ATP + acetyl-CoA + HCO3- = ADP + phosphate + malonyl-CoA. GO:0009317A protein complex that catalyzes the first step in long-chain fatty acid biosynthesis. For example, in E. coli the complex is heterohexameric and composed of biotin carbonyl carrier protein, biotin carboxylase and the acetate CoA-transferase complex. GO:0006633The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes.
No map — No pocket Hit — —
11 HT085_RS00120 helix-turn-helix transcriptional regulator ColabFold model –
GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
No map — No pocket No Hit — —
12 HT085_RS00240 tRNA preQ1(34) S-adenosylmethionine ribosyltransferase-isomerase QueA queA AlphaFold DB model
2.4.99.17
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0051075Catalysis of the reaction: S-adenosylmethionine + 7-(aminomethyl)-7-deazaguanosine-tRNA = adenine + methionine + epoxyqueuosine-tRNA. 7-(aminomethyl)-7-deazaguanosine-tRNA is also known as preQ1-tRNA, and epoxyqueuosine-tRNA as oQ-tRNA. GO:0008616The chemical reactions and pathways resulting in the formation of queuosines, a series of nucleosides found in position 34 of tRNA and having an additional pentenyl ring added via an NH group to the methyl group of 7-methylguanosine. The pentenyl ring may carry other substituents. The wobble nucleoside of the tRNA sequence (position 34) corresponds to the first position of the anticodon.
No map — No pocket No Hit — —
13 HT085_RS00150 ribosomal protein S18-alanine N-acetyltransferase rimI ColabFold model –
GO:0016747Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor).
No map — No pocket No Hit — —
14 HT085_RS00340 hypothetical protein ColabFold model – – No map — No pocket No Hit — —
15 HT085_RS00245 carbamoyl-phosphate synthase large subunit carB ColabFold model –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0046872Binding to a metal ion.
No map — No pocket Hit — —
16 HT085_RS00115 siderophore ABC transporter substrate-binding protein AlphaFold DB model –
GO:0030288The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin peptidoglycan layer (PGL), also referred to as a thin cell wall. GO:1901678The directed movement of an iron coordination entity into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
No map — No pocket No Hit — —
17 HT085_RS00250 hypothetical protein AlphaFold DB model – – No map — No pocket No Hit — —
18 HT085_RS00080 preprotein translocase subunit SecG secG AlphaFold DB model –
GO:0009306The controlled release of proteins from a cell. GO:0015450Primary active carrier-mediated transport of a protein across a membrane, driven by the hydrolysis of the diphosphate bond of inorganic pyrophosphate, ATP, or another nucleoside triphosphate. The transport protein may or may not be transiently phosphorylated, but the substrate is not phosphorylated. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. +25 total
No map — No pocket No Hit — —
19 HT085_RS00105 TonB-dependent iron piracy receptor TdfF tdfF ColabFold model – – No map — No pocket No Hit — —
20 HT085_RS00270 glutamine-hydrolyzing carbamoyl-phosphate synthase small subunit carA ColabFold model –
GO:0006207The chemical reactions and pathways resulting in the formation of pyrimidine nucleobases, 1,3-diazine, organic nitrogenous bases, beginning with the synthesis of a pyrimidine ring from simpler precursors.
No map — No pocket Hit — —
21 HT085_RS00275 PilC family type IV pilus tip adhesin pilC ColabFold model – – No map — No pocket No Hit — —
22 HT085_RS00350 bifunctional riboflavin kinase/FAD synthetase ribF ColabFold model – – No map — No pocket Hit — —
23 HT085_RS00235 hypothetical protein AlphaFold DB model – – No map — No pocket No Hit — —
24 HT085_RS00280 iron-sulfur cluster carrier protein ApbC apbC AlphaFold DB model –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0140663Binding to and delivering metal ions to a target protein, driven by ATP hydrolysis. GO:0016226The incorporation of iron and exogenous sulfur into a metallo-sulfur cluster. +36 total
No map — No pocket Hit — —
25 HT085_RS00365 opacity family porin ColabFold model – – No map — No pocket No Hit — —
Page of 3 · 62 total proteins