Proteins

Genome: KpATCC43816

Description: Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome

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5081 / 5081 proteins

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# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
2976 VK055_3862 putative P-loop containing ATPase AlphaFold + ColabFold –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0005525Binding to GTP, guanosine triphosphate. GO:0003723Binding to an RNA molecule or a portion thereof.
0.484 No Hit 0.0% —
2977 VK055_3685 4-alpha-glucanotransferase malQ AlphaFold + ColabFold
2.4.1.25
GO:0004134Catalysis of the transfer of a segment of a (1->4)-alpha-D-glucan to a new 4-position in an acceptor, which may be glucose or (1->4)-alpha-D-glucan. GO:0005975The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y.
0.484 No Hit 0.0% —
2978 VK055_2688 putative LACI-type transcriptional regulator Experimental + ColabFold – – 0.484 No Hit 0.0% —
2979 VK055_2615 putative DNA-binding transcriptional regulator AlphaFold + ColabFold –
GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
0.484 No Hit 0.0% —
2980 VK055_1658 aldose sugar dehydrogenase yliI AlphaFold + ColabFold – – 0.484 Hit 28.5% 1.37e-13
2981 VK055_5161 hypothetical protein AlphaFold + ColabFold – – 0.483 No Hit 0.0% —
2982 VK055_4974 hypothetical protein ColabFold – – 0.483 No Hit 0.0% —
2983 VK055_3744 dsrE/DsrF-like family protein AlphaFold + ColabFold
2.8.1.-
GO:0016783Catalysis of the transfer of sulfur atoms from one compound (donor) to another (acceptor). GO:0008033The process in which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. +36 total
0.483 No Hit 0.0% —
2984 VK055_3064 23S rRNA pseudouridine 2604 synthase AlphaFold + ColabFold
5.4.99.-
GO:0016866Catalysis of the transfer of a functional group from one position to another within a single molecule. GO:0009451The covalent alteration of one or more nucleotides within an RNA molecule to produce an RNA molecule with a sequence that differs from that coded genetically. GO:0003723Binding to an RNA molecule or a portion thereof. +47 total
0.483 No Hit 0.0% —
2985 VK055_1518 aliphatic sulfonates import ATP-binding protein SsuB ssuB AlphaFold + ColabFold –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. GO:0042918The directed movement of an alkanesulfonate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Alkanesulfonates are organic esters or salts of sulfonic acid containing an aliphatic hydrocarbon radical.
0.483 Hit 48.1% 3.96e-06
2986 VK055_1429 hypothetical protein AlphaFold + ColabFold –
GO:0042597The region between the inner (cytoplasmic) and outer membrane (Gram-negative Bacteria) or cytoplasmic membrane and cell wall (Fungi and Gram-positive Bacteria).
0.483 No Hit 0.0% —
2987 VK055_0426 endoribonuclease L-PSP family protein AlphaFold + ColabFold –
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0019239Catalysis of the removal of an amino group from a substrate, producing a substituted or nonsubstituted ammonia (NH4+/NH2R).
0.483 No Hit 0.0% —
2988 VK055_4484 competence/damage-inducible CinA C-terminal domain protein AlphaFold + ColabFold – – 0.482 No Hit 0.0% —
2989 VK055_4275 6-phospho-beta-glucosidase gmuD gmuD AlphaFold + ColabFold –
GO:0004553Catalysis of the hydrolysis of any O-glycosyl bond. GO:0005975The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. +25 total
0.482 Hit 29.9% 4.29e-11
2990 VK055_3527 mannitol dehydrogenase Rossmann domain protein AlphaFold + ColabFold
1.1.1.17
GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0008926Catalysis of the reaction: D-mannitol 1-phosphate + NAD+ = D-fructose 6-phosphate + NADH + H+. GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. +36 total
0.482 No Hit 0.0% —
2991 VK055_2250 ethanolamine ammonia-lyase light chain family protein AlphaFold + ColabFold
4.3.1.7
GO:0006520The chemical reactions and pathways involving amino acids, carboxylic acids containing one or more amino groups. GO:0008851Catalysis of the reaction: ethanolamine = acetaldehyde + NH4+. GO:0009350An enzyme complex that catalyzes the breakdown of ethanolamine to form acetaldehyde and ammonia. +36 total
0.482 No Hit 0.0% —
2992 VK055_1570 translation initiation factor IF-1 infA AlphaFold + ColabFold –
GO:0003743Functions in the initiation of ribosome-mediated translation of mRNA into a polypeptide. GO:0006413The process preceding formation of the peptide bond between the first two amino acids of a protein. This includes the formation of a complex of the ribosome, mRNA or circRNA, and an initiation complex that contains the first aminoacyl-tRNA. GO:0003723Binding to an RNA molecule or a portion thereof. +36 total
0.482 No Hit 0.0% —
2993 VK055_1493 hypothetical protein Experimental + AlphaFold + ColabFold – – 0.482 No Hit 0.0% —
2994 VK055_1490 phosphatidylethanolamine-binding family protein AlphaFold + ColabFold – – 0.482 No Hit 0.0% —
2995 VK055_1332 potC potC AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
0.482 No Hit 0.0% —
2996 VK055_1029 phenylacetic acid degradation protein PaaY paaY AlphaFold + ColabFold –
GO:0016740Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2.
0.482 No Hit 0.0% —
2997 VK055_4802 putative flagellar assembly protein AlphaFold + ColabFold –
GO:0010468Any process that modulates the frequency, rate or extent of gene expression. Gene expression is the process in which a gene's coding sequence is converted into a mature gene product (protein or RNA). GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
0.481 No Hit 0.0% —
2998 VK055_4198 acid stress chaperone hdeB AlphaFold + ColabFold –
GO:0009268Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pH stimulus. pH is a measure of the acidity or basicity of an aqueous solution. GO:0051082Binding to an unfolded protein. GO:0042597The region between the inner (cytoplasmic) and outer membrane (Gram-negative Bacteria) or cytoplasmic membrane and cell wall (Fungi and Gram-positive Bacteria). +14 total
0.481 No Hit 0.0% —
2999 VK055_3249 cell division protein FtsN ftsN AlphaFold + ColabFold –
GO:0005515Binding to a protein. GO:0042834Interacting selectively and non-covalently, in a non-covalent manner, with peptidoglycan, any of a class of glycoconjugates found in bacterial cell walls. GO:0032153The eventual plane of cell division (also known as cell cleavage or cytokinesis) in a dividing cell. In Eukaryotes, the cleavage apparatus, composed of septin structures and the actomyosin contractile ring, forms along this plane, and the mitotic, or meiotic, spindle is aligned perpendicular to the division plane. In bacteria, the cell division site is generally located at mid-cell and is the site at which the cytoskeletal structure, the Z-ring, assembles. +36 total
0.481 No Hit 0.0% —
3000 VK055_2803 amidohydrolase family protein AlphaFold + ColabFold –
GO:0016810Catalysis of the hydrolysis of any carbon-nitrogen bond, C-N, with the exception of peptide bonds.
0.481 No Hit 0.0% —
Page of 204 · 5081 total proteins