Proteins

Genome: KpATCC43816

Description: Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome

Search, filter, and prioritize proteins.

Export view
5081 proteins

Scoring formula None

Sorted by Druggability (descending)

Applied filters No active filters

Search query No active search

Rows per page 25

Rows
# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
3351 VK055_1512 putative 2Fe-2S cluster-containing protein AlphaFold + ColabFold –
GO:0051537Binding to a 2 iron, 2 sulfur (2Fe-2S) cluster; this cluster consists of two iron atoms, with two inorganic sulfur atoms found between the irons and acting as bridging ligands. GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0030151Binding to a molybdenum ion (Mo). +25 total
0.417 Hit 45.2% 1.36e-19
3352 VK055_0068 dATP pyrophosphohydrolase ntpA AlphaFold + ColabFold –
GO:0019177Catalysis of the reaction: dihydroneopterin triphosphate = dihydroneopterin phosphate + diphosphate. GO:0046656The chemical reactions and pathways resulting in the formation of folic acid, pteroylglutamic acid. GO:0008828Catalysis of the reaction: dATP + H2O = dAMP + H+ + diphosphate. +47 total
0.417 Hit 30.6% 1.28e-07
3353 VK055_5075 winged helix-turn-helix DNA-binding family protein AlphaFold + ColabFold – – 0.416 No Hit 0.0% —
3354 VK055_4396 hypothetical protein AlphaFold + ColabFold – – 0.416 No Hit 0.0% —
3355 VK055_3515 rhodanese-like domain protein AlphaFold + ColabFold – – 0.416 No Hit 0.0% —
3356 VK055_3508 ADP-glyceromanno-heptose 6-epimerase rfaD AlphaFold + ColabFold
5.1.3.20
GO:0050661Binding to nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP+, or the reduced form, NADPH. GO:0008712Catalysis of the reaction: ADP-D-glycero-D-manno-heptose = ADP-L-glycero-D-manno-heptose. GO:0005975The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. +25 total
0.416 Hit 25.4% 4.21e-06
3357 VK055_3035 tRNA-dihydrouridine synthase A yjbN AlphaFold + ColabFold
1.3.1.91
GO:0008033The process in which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group. GO:0017150Catalysis of the reaction: a 5,6-dihydrouridine in tRNA + NAD(P)+ = a uridine in tRNA + H+ + NAD(P)H. GO:0050660Binding to FAD, flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes, in either the oxidized form, FAD, or the reduced form, FADH2. +58 total
0.416 Hit 30.9% 2.22e-07
3358 VK055_1333 potD potD AlphaFold + ColabFold –
GO:0015846The directed movement of polyamines, organic compounds containing two or more amino groups, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. GO:0019808Binding to a polyamine, an organic compound containing two or more amino groups. GO:0042597The region between the inner (cytoplasmic) and outer membrane (Gram-negative Bacteria) or cytoplasmic membrane and cell wall (Fungi and Gram-positive Bacteria). +14 total
0.416 No Hit 0.0% —
3359 VK055_1237 astC AlphaFold + ColabFold
2.6.1.11 2.6.1.17
GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0006525The chemical reactions and pathways involving arginine, 2-amino-5-(carbamimidamido)pentanoic acid. GO:0008483Catalysis of the transfer of an amino group to an acceptor, usually a 2-oxo acid. +912 total
0.416 Hit 37.1% 1.90e-06
3360 VK055_0761 peptidase, ArgE/DapE family protein AlphaFold + ColabFold
3.5.1.18
GO:0016787Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. GO:0046872Binding to a metal ion. GO:0009014Catalysis of the reaction: N-succinyl-LL-2,6-diaminopimelate + H2O = LL-2,6-diaminopimelate + succinate. +14 total
0.416 Hit 23.6% 5.24e-09
3361 VK055_4356 L-fucose mutarotase fucU AlphaFold + ColabFold
5.1.3.29
GO:0005996The chemical reactions and pathways involving monosaccharides, the simplest carbohydrates. They are polyhydric alcohols containing either an aldehyde or a keto group and between three to ten or more carbon atoms. They form the constitutional repeating units of oligo- and polysaccharides. GO:0016853Catalysis of the geometric or structural changes within one molecule. Isomerase is the systematic name for any enzyme of EC class 5. GO:0042354The chemical reactions and pathways involving L-fucose, 6-deoxy-L-galactose, a sugar that occurs in fucans, a class of polysaccharides in seaweeds, especially Fucus species, and in the cell wall matrix of higher plants. +69 total
0.415 Hit 47.2% 2.05e-36
3362 VK055_3519 serine O-acetyltransferase cysE Experimental + ColabFold –
GO:0009001Catalysis of the reaction: L-serine + acetyl-CoA = O-acetyl-L-serine + CoA. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0006535OBSOLETE. The chemical reactions and pathways resulting in the formation of cysteine from L- serine. +14 total
0.415 No Hit 0.0% —
3363 VK055_3023 hypothetical protein AlphaFold + ColabFold – – 0.415 No Hit 0.0% —
3364 VK055_1539 3-deoxy-D-manno-octulosonate cytidylyltransferase kdsB Experimental + ColabFold
2.7.7.38
GO:0008690Catalysis of the reaction: CTP + 3-deoxy-D-manno-octulosonate = diphosphate + CMP-3-deoxy-D-manno-octulosonate. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. +25 total
0.415 No Hit 0.0% —
3365 VK055_1216 2-deoxyglucose-6-phosphatase AlphaFold + ColabFold –
GO:0016787Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. GO:0000287Binding to a magnesium (Mg) ion.
0.415 Hit 27.0% 2.23e-10
3366 VK055_1064 bacterial regulatory, arsR family protein AlphaFold + ColabFold –
GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
0.415 No Hit 0.0% —
3367 VK055_0414 3-oxoacid CoA-transferase, B subunit AlphaFold + ColabFold –
GO:0008410Catalysis of the transfer of a coenzyme A (CoA) group from one compound (donor) to another (acceptor).
0.415 Hit 49.8% 2.06e-69
3368 VK055_4197 hypothetical protein ColabFold – – 0.414 No Hit 0.0% —
3369 VK055_4012 tRNA nucleotidyltransferase cca AlphaFold + ColabFold –
GO:0006396Any process involved in the conversion of one or more primary RNA transcripts into one or more mature RNA molecules. GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0001680Post-transcriptional addition of the terminal 3' CCA sequence to a tRNA which does not encode this sequence within the primary transcript. CCA addition proceeds by the sequential addition of CTP, CTP, and then ATP to the 3' end of the tRNA, yielding a diphosphate with each nucleotide addition. +912 total
0.414 Hit 31.4% 9.20e-09
3370 VK055_3948 uronate isomerase uxaC AlphaFold + ColabFold
5.3.1.12
GO:0006064The chemical reactions and pathways resulting in the breakdown of glucuronate, any salt or ester of glucuronic acid. GO:0008880Catalysis of the reaction: D-glucuronate = D-fructuronate. Also converts D-galacturonate to D-tagaturonate. GO:0019698The chemical reactions and pathways resulting in the breakdown of D-galacturonate, the D-enantiomer of galacturonate, the anion of galacturonic acid. +14 total
0.414 No Hit 0.0% —
3371 VK055_3734 hypothetical protein AlphaFold + ColabFold – – 0.414 No Hit 0.0% —
3372 VK055_2815 6-phospho-beta-glucosidase AlphaFold + ColabFold –
GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0004553Catalysis of the hydrolysis of any O-glycosyl bond. GO:0005975The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. +25 total
0.414 No Hit 0.0% —
3373 VK055_0906 hypothetical protein AlphaFold + ColabFold – – 0.414 No Hit 0.0% —
3374 VK055_0074 ABC transporter family protein AlphaFold + ColabFold –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. GO:0010043Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a zinc ion stimulus. +14 total
0.414 Hit 41.5% 1.32e-07
3375 VK055_4933 hypothetical protein AlphaFold + ColabFold – – 0.413 No Hit 0.0% —
Page of 204 · 5081 total proteins