Proteins

Genome: KpATCC43816

Description: Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome

Search, filter, and prioritize proteins.

Export view
5081 / 5081 proteins
No filters or custom sorting applied — click to see defaults

Scoring formula None

Sorted by Druggability (P2Rank preferred) (descending)

Applied filters No active filters

Search query No active search

Rows per page 25

Rows
# Protein Description Gene Structure EC GO Metabolism Druggability (P2Rank) P2RANK ligandability score for the best pocket in the experimental structure (0–1). Higher values indicate higher predicted ligandability. Available only for genomes analyzed with the curated pipeline. Druggability (FPocket) FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
3626 VK055_2625 hypothetical protein AlphaFold DB model + ColabFold model –
GO:1990238Catalysis of the hydrolysis of ester linkages within a double-stranded DNA molecule by creating internal breaks. GO:0006310Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Interchromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction.
No map 0.257 0.678 No Hit 0.0% —
3627 VK055_4128 fructose-bisphosphate aldolase, class II fbaA AlphaFold DB model + ColabFold model
4.1.2.13
GO:0005975The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. GO:0016832Catalysis of the cleavage of a C-C bond in a molecule containing a hydroxyl group and a carbonyl group to form two smaller molecules, each being an aldehyde or a ketone. GO:0008270Binding to a zinc ion (Zn). +47 total
Mapped 4 0.256 0.48 No Hit 0.0% —
3628 VK055_3759 30S ribosomal subunit protein S19 rpsS ColabFold model –
GO:0003735The action of a molecule that contributes to the structural integrity of the ribosome. GO:0006412The cellular metabolic process in which a protein is formed, using the sequence of a mature mRNA or circRNA molecule to specify the sequence of amino acids in a polypeptide chain. Translation is mediated by the ribosome, and begins with the formation of a ternary complex between aminoacylated initiator methionine tRNA, GTP, and initiation factor 2, which subsequently associates with the small subunit of the ribosome and an mRNA or circRNA. Translation ends with the release of a polypeptide chain from the ribosome. GO:0005840An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins. +14 total
No map N/A 0.256 No Hit 0.0% —
3629 VK055_3497 3-deoxy-D-manno-octulosonic-acid transferase waaA AlphaFold DB model + ColabFold model
2.4.99.12
GO:0016740Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0043842Catalysis of the reactions: (KDO)-lipid IVA + CMP-3-deoxy-D-manno-octulosonate = KDO2-lipid IVA + CMP, and lipid IVA + CMP-3-deoxy-D-manno-octulosonate = (KDO)-lipid IVA + CMP. +25 total
Chokepoint 5 0.256 0.276 No Hit 0.0% —
3630 VK055_1871 bacterial regulatory helix-turn-helix, lysR family protein AlphaFold DB model + ColabFold model –
GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
No map 0.256 0.466 No Hit 0.0% —
3631 VK055_1025 putative O-METHYLTRANSFERASE Experimental + ColabFold model –
GO:0008171Catalysis of the transfer of a methyl group to the oxygen atom of an acceptor molecule.
No map 0.256 0.44 Hit 36.5% 5.70e-11
3632 VK055_4538 bacterial regulatory, luxR family protein AlphaFold DB model + ColabFold model –
GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
No map 0.255 0.972 No Hit 0.0% —
3633 VK055_2875 ulaC ulaC AlphaFold DB model + ColabFold model –
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0016301Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. GO:0009401The uptake and phosphorylation of specific carbohydrates from the extracellular environment; uptake and phosphorylation are coupled, making the PTS a link between the uptake and metabolism of sugars; phosphoenolpyruvate is the original phosphate donor; phosphoenolpyruvate passes the phosphate via a signal transduction pathway, to enzyme 1 (E1), which in turn passes it on to the histidine protein, HPr; the next step in the system involves sugar-specific membrane-bound complex, enzyme 2 (EII), which transports the sugar into the cell; it includes the sugar permease, which catalyzes the transport reactions; EII is usually divided into three different domains, EIIA, EIIB, and EIIC.
No map 0.255 0.297 No Hit 0.0% —
3634 VK055_2175 nucleotide binding protein yajQ AlphaFold DB model + ColabFold model –
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0000166Binding to a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose.
No map N/A 0.255 No Hit 0.0% —
3635 VK055_0669 mgtC family magnesium transporter domain protein mgtC2 AlphaFold DB model + ColabFold model – – No map 0.255 0.107 No Hit 0.0% —
3636 VK055_0596 ABC transporter family protein AlphaFold DB model + ColabFold model –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0006826The directed movement of iron (Fe) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. +36 total
No map 0.255 0.27 Hit 50.0% 1.00e-06
3637 VK055_1604 potF potF AlphaFold DB model + ColabFold model –
GO:0015846The directed movement of polyamines, organic compounds containing two or more amino groups, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. GO:0019808Binding to a polyamine, an organic compound containing two or more amino groups. GO:0042597The region between the inner (cytoplasmic) and outer membrane (Gram-negative Bacteria) or cytoplasmic membrane and cell wall (Fungi and Gram-positive Bacteria). +14 total
No map 0.254 0.609 No Hit 0.0% —
3638 VK055_4466 putative electron transport protein HydN AlphaFold DB model + ColabFold model –
GO:0051539Binding to a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands. GO:0046872Binding to a metal ion.
No map 0.253 0.451 No Hit 0.0% —
3639 VK055_3884 obg family GTPase CgtA cgtA AlphaFold DB model + ColabFold model
3.6.5.-
GO:0005525Binding to GTP, guanosine triphosphate. GO:0000287Binding to a magnesium (Mg) ion. GO:0003924Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate. +47 total
No map 0.253 0.603 Hit 44.2% 5.00e-17
3640 VK055_3990 bacterial regulatory, luxR family protein AlphaFold DB model + ColabFold model –
GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0000160A conserved series of molecular signals found in prokaryotes and eukaryotes; involves autophosphorylation of a histidine kinase and the transfer of the phosphate group to an aspartate that then acts as a phospho-donor to response regulator proteins.
No map N/A 0.252 No Hit 0.0% —
3641 VK055_3165 tyrosine recombinase XerC xerC AlphaFold DB model + ColabFold model –
GO:0015074The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome. GO:0007059The process in which genetic material, in the form of chromosomes, is organized into specific structures and then physically separated and apportioned to two or more sets. In eukaryotes, chromosome segregation begins with the condensation of chromosomes, includes chromosome separation, and ends when chromosomes have completed movement to the spindle poles. GO:0006310Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Interchromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction. +58 total
No map 0.252 0.444 No Hit 0.0% —
3642 VK055_3104 hypothetical protein AlphaFold DB model + ColabFold model – – No map N/A 0.252 No Hit 0.0% —
3643 VK055_2227 pyrroline-5-carboxylate reductase proC AlphaFold DB model + ColabFold model
1.5.1.2
GO:0004735Catalysis of the reaction: L-proline + NADP+ = 1-pyrroline-5-carboxylate + NADPH + H+. GO:0006561OBSOLETE. The chemical reactions and pathways resulting in the formation of proline (pyrrolidine-2-carboxylic acid), a chiral, cyclic, nonessential alpha-amino acid found in peptide linkage in proteins. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. +14 total
Mapped 4 0.252 0.363 Hit 50.6% 9.52e-20
3644 VK055_2209 isochorismatase family protein AlphaFold DB model + ColabFold model –
GO:0016787Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc.
No map 0.252 0.6 No Hit 0.0% —
3645 VK055_1408 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.252 0.876 No Hit 0.0% —
3646 VK055_2876 ulaB sgaB AlphaFold DB model + ColabFold model –
GO:0009401The uptake and phosphorylation of specific carbohydrates from the extracellular environment; uptake and phosphorylation are coupled, making the PTS a link between the uptake and metabolism of sugars; phosphoenolpyruvate is the original phosphate donor; phosphoenolpyruvate passes the phosphate via a signal transduction pathway, to enzyme 1 (E1), which in turn passes it on to the histidine protein, HPr; the next step in the system involves sugar-specific membrane-bound complex, enzyme 2 (EII), which transports the sugar into the cell; it includes the sugar permease, which catalyzes the transport reactions; EII is usually divided into three different domains, EIIA, EIIB, and EIIC. GO:0008982Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + sugar(out) = protein histidine + sugar phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport.
No map 0.251 0.6 No Hit 0.0% —
3647 VK055_2790 putative ATPase AlphaFold DB model + ColabFold model – – No map 0.251 0.603 No Hit 0.0% —
3648 VK055_1049 ynbE-like lipofamily protein AlphaFold DB model + ColabFold model – – No map N/A 0.251 No Hit 0.0% —
3649 VK055_0043 hypothetical protein AlphaFold DB model + ColabFold model – – No map N/A 0.251 No Hit 0.0% —
3650 VK055_3634 sirA-like family protein AlphaFold DB model + ColabFold model –
GO:0002143The process in which a uridine residue at position 34 in the anticodon of a tRNA is post-transcriptionally thiolated at the C2 position. This process involves transfer of a sulfur from cysteine to position C2 by several steps. GO:0097163Covalently binding to sulfur and delivering it to an acceptor molecule. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
No map N/A 0.25 No Hit 0.0% —
Page of 204 · 5081 total proteins