Proteins

Genome: KpATCC43816

Description: Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome

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# Protein Description Gene Structure EC GO Metabolism Druggability (P2Rank) P2RANK ligandability score for the best pocket in the experimental structure (0–1). Higher values indicate higher predicted ligandability. Available only for genomes analyzed with the curated pipeline. Druggability (FPocket) FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
3601 VK055_0262 oligopeptide/dipeptide ABC transporter, ATP-binding, C-terminal domain protein AlphaFold DB model + ColabFold model –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0015833The directed movement of peptides, compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. GO:0000166Binding to a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose. +14 total
No map 0.266 0.481 Hit 32.8% 2.25e-21
3602 VK055_1883 peroxiredoxin ahpC AlphaFold DB model + ColabFold model
1.11.1.26
GO:0016209Inhibition of the reactions brought about by dioxygen (O2) or peroxides. Usually the antioxidant is effective because it can itself be more easily oxidized than the substance protected. The term is often applied to components that can trap free radicals, thereby breaking the chain reaction that normally leads to extensive biological damage. GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. GO:0006979Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of oxidative stress, a state often resulting from exposure to high levels of reactive oxygen species, e.g. superoxide anions, hydrogen peroxide (H2O2), and hydroxyl radicals. +710 total
Chokepoint 8 N/A 0.265 Hit 43.4% 3.99e-17
3603 VK055_2561 hypothetical protein AlphaFold DB model + ColabFold model – – No map N/A 0.264 No Hit 0.0% —
3604 VK055_1355 hypothetical protein AlphaFold DB model + ColabFold model – – No map N/A 0.264 No Hit 0.0% —
3605 VK055_4331 precorrin-6Y C5,15-methyltransferase (decarboxylating), CbiT subunit cbiT AlphaFold DB model + ColabFold model –
GO:0008168Catalysis of the transfer of a methyl group to an acceptor molecule. GO:0008276Catalysis of the transfer of a methyl group (CH3-) to a protein. GO:0009236The chemical reactions and pathways resulting in the formation of cobalamin (vitamin B12), a water-soluble vitamin characterized by possession of a corrin nucleus containing a cobalt atom. +14 total
Chokepoint 3 0.263 0.386 No Hit 0.0% —
3606 VK055_1645 putative repressor protein ColabFold model –
GO:0051259The process of creating protein oligomers, compounds composed of a small number, usually between three and ten, of component monomers; protein oligomers may be composed of different or identical monomers. Oligomers may be formed by the polymerization of a number of monomers or the depolymerization of a large protein polymer.
No map N/A 0.263 No Hit 0.0% —
3607 VK055_0099 hypothetical protein AlphaFold DB model + ColabFold model –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
No map 0.263 0.282 No Hit 0.0% —
3608 VK055_3008 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.262 0.565 No Hit 0.0% —
3609 VK055_2186 transcription antitermination factor NusB nusB AlphaFold DB model + ColabFold model –
GO:0006353The completion of transcription: the RNA polymerase pauses, the RNA-DNA hybrid dissociates, followed by the release of the RNA polymerase from its DNA template. GO:0003723Binding to an RNA molecule or a portion thereof. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. +25 total
No map N/A 0.262 No Hit 0.0% —
3610 VK055_3877 bolA-like family protein AlphaFold DB model + ColabFold model – – No map N/A 0.261 Hit 35.0% 2.86e-07
3611 VK055_3723 major Facilitator Superfamily protein ColabFold model –
GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.
No map 0.261 0.67 No Hit 0.0% —
3612 VK055_1358 glycine-zipper containing OmpA-like membrane domain protein AlphaFold DB model + ColabFold model –
GO:0019867The external membrane of Gram-negative bacteria or certain organelles such as mitochondria and chloroplasts; freely permeable to most ions and metabolites.
No map N/A 0.261 No Hit 0.0% —
3613 VK055_0645 protein yciE yciE AlphaFold DB model + ColabFold model – – No map 0.261 0.91 No Hit 0.0% —
3614 VK055_0643 hypothetical protein AlphaFold DB model + ColabFold model – – No map N/A 0.261 No Hit 0.0% —
3615 VK055_3742 peptidyl-prolyl cis-trans isomerase in protein folding AlphaFold DB model + ColabFold model
5.2.1.8
GO:0006457The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. GO:0003755Catalysis of the reaction: peptidyl-proline (omega=180) = peptidyl-proline (omega=0).
Mapped 2 0.260 0.163 Hit 52.5% 1.42e-17
3616 VK055_2576 inner membrane CreD family protein AlphaFold DB model + ColabFold model –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
No map 0.260 0.971 No Hit 0.0% —
3617 VK055_2109 hypothetical protein AlphaFold DB model + ColabFold model – – No map N/A 0.26 No Hit 0.0% —
3618 VK055_0589 helix-turn-helix family protein AlphaFold DB model + ColabFold model –
GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
No map N/A 0.259 No Hit 0.0% —
3619 VK055_0094 hypothetical protein AlphaFold DB model + ColabFold model –
GO:0006974Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism.
No map 0.259 0.858 No Hit 0.0% —
3620 VK055_4045 conserved inner membrane protein yghB AlphaFold DB model + ColabFold model – – No map 0.258 0.886 No Hit 0.0% —
3621 VK055_2139 GlnK glnK AlphaFold DB model + ColabFold model –
GO:0006808Any process that modulates the frequency, rate or extent of nitrogen utilization. GO:0030234A molecular function regulator that modulates a catalytic activity. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. +14 total
No map N/A 0.258 No Hit 0.0% —
3622 VK055_4266 ABC transporter family protein AlphaFold DB model + ColabFold model –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0140359Primary active transporter characterized by two nucleotide-binding domains and two transmembrane domains. Uses the energy generated from ATP hydrolysis to drive the transport of a substance across a membrane. GO:0008643The directed movement of carbohydrate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Carbohydrates are a group of organic compounds based of the general formula Cx(H2O)y. +47 total
No map 0.257 0.317 Hit 32.6% 1.10e-16
3623 VK055_3728 glutamine amidotransferase of anthranilate synthase/aminodeoxychorismate synthase family protein AlphaFold DB model + ColabFold model –
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0046820Catalysis of the reaction: L-glutamine + chorismate = 4-amino-4-deoxychorismate + L-glutamate. It is composed of two enzymatic activities (which may be present on one or two polypeptides); the first is a glutaminase which yields ammonia from glutamine, releasing glutamate. The ammonia is used by the second activity which catalyzes the amination of chorismate to form 4-amino-4-deoxychorismate. GO:0004049Catalysis of the reaction: chorismate + L-glutamine = anthranilate + pyruvate + L-glutamate. +36 total
No map 0.257 0.107 Hit 33.9% 5.32e-11
3624 VK055_3450 helix-turn-helix domain, rpiR family protein AlphaFold DB model + ColabFold model –
GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:1901135The chemical reactions and pathways involving carbohydrate derivative. GO:0097367Binding to a carbohydrate derivative. +25 total
No map 0.257 0.827 No Hit 0.0% —
3625 VK055_3013 ABC transporter family protein AlphaFold DB model + ColabFold model –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. GO:0043190A complex for the transport of metabolites into and out of the cell, typically comprised of four domains; two membrane-associated domains and two ATP-binding domains at the intracellular face of the membrane, that form a central pore through the plasma membrane. Each of the four core domains may be encoded as a separate polypeptide or the domains can be fused in any one of a number of ways into multidomain polypeptides. In Bacteria and Archaebacteria, ABC transporters also include substrate binding proteins to bind substrate external to the cytoplasm and deliver it to the transporter. +14 total
No map 0.257 0.378 Hit 36.4% 4.91e-21
Page of 204 · 5081 total proteins