Proteins

Genome: KpATCC43816

Description: Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome

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5081 proteins

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# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
3676 VK055_0176 bacterial extracellular solute-binding family protein AlphaFold + ColabFold –
GO:0030973Binding to a molybdate ion (MoO4 2-). GO:0015689The directed movement of molybdate (MoO4 2-) ions into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Molybdate is the bivalent anion derived from molybdic acid.
0.363 No Hit 0.0% —
3677 VK055_2082 cu(I)-responsive transcriptional regulator cueR AlphaFold + ColabFold –
GO:0005507Binding to a copper (Cu) ion. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. +36 total
0.362 No Hit 0.0% —
3678 VK055_1938 heme ABC exporter, ATP-binding protein CcmA ccmA5 AlphaFold + ColabFold
3.6.3.17
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
0.362 Hit 34.7% 4.27e-17
3679 VK055_1875 crcB-like family protein AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0062054Enables the energy-independent facilitated diffusion of a fluoride ion through a transmembrane aqueous pore or channel. +25 total
0.362 No Hit 0.0% —
3680 VK055_1420 putative h-NS-like DNA-binding protein AlphaFold + ColabFold –
GO:0046983The formation of a protein dimer, a macromolecular structure consists of two noncovalently associated identical or nonidentical subunits. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
0.362 No Hit 0.0% —
3681 VK055_0964 3-oxoadipate CoA-transferase subunit B catJ AlphaFold + ColabFold –
GO:0008410Catalysis of the transfer of a coenzyme A (CoA) group from one compound (donor) to another (acceptor).
0.362 Hit 44.7% 7.51e-54
3682 VK055_5144 protein mtfA mtfA2 Experimental + ColabFold –
GO:0008237Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions.
0.361 No Hit 0.0% —
3683 VK055_2417 type II secretion system (T2SS), M family protein AlphaFold + ColabFold –
GO:0015627A large protein complex, containing 12-15 subunits, that spans the cell envelope of Gram-negative bacteria and mediates the movement of proteins into the extracellular environment. The complex includes a component in the cytoplasm, an inner membrane subcomplex that reaches into the periplasmic compartment and a secretion pore in the outer membrane. Proteins using the Type II pathway are transported across the cytoplasmic membrane by the Sec or Tat complex. GO:0015628The process in which proteins are secreted across the outer membrane of Gram-negative bacteria by the type II secretion system. Proteins using this pathway are first translocated across the cytoplasmic membrane via the Sec or Tat pathways. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
0.361 No Hit 0.0% —
3684 VK055_1959 ABC transporter family protein AlphaFold + ColabFold
7.4.2.10
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. +14 total
0.361 Hit 51.0% 1.33e-07
3685 VK055_1893 ABC transporter family protein AlphaFold + ColabFold –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.
0.361 Hit 35.0% 1.57e-07
3686 VK055_1482 anti-anti-sigma factor family protein AlphaFold + ColabFold –
GO:0043856The function of binding to an anti-sigma factor and stopping, preventing or reducing the rate of its activity. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
0.361 No Hit 0.0% —
3687 VK055_1249 gdhA AlphaFold + ColabFold –
GO:0006520The chemical reactions and pathways involving amino acids, carboxylic acids containing one or more amino groups. GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. GO:0016639Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH2 group acts as a hydrogen or electron donor and reduces NAD+ or NADP. +47 total
0.361 Hit 31.8% 3.41e-17
3688 VK055_1038 phenylacetate-CoA oxygenase, PaaJ subunit paaJ AlphaFold + ColabFold – – 0.361 No Hit 0.0% —
3689 VK055_4822 dihydroneopterin triphosphate 2'-epimerase folX AlphaFold + ColabFold
5.1.99.7
GO:0004150Catalysis of the reaction: 2-amino-4-hydroxy-6-(D-erythro-1,2,3-trihydroxypropyl)-7,8-dihydropteridine = 2-amino-4-hydroxy-6-hydroxymethyl-7,8-dihydropteridine + glycolaldehyde. GO:0006760The chemical reactions and pathways involving a folic acid-containing compound, i.e. any of a group of heterocyclic compounds based on the pteroic acid skeleton conjugated with one or more L-glutamic acid or L-glutamate units. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. +25 total
0.36 No Hit 0.0% —
3690 VK055_3835 bacterial regulatory, gntR family protein AlphaFold + ColabFold –
GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
0.36 No Hit 0.0% —
3691 VK055_1393 dinI-like family protein AlphaFold + ColabFold –
GO:0009432An error-prone process for repairing damaged microbial DNA.
0.36 No Hit 0.0% —
3692 VK055_0252 hypothetical protein AlphaFold + ColabFold – – 0.36 No Hit 0.0% —
3693 VK055_0171 phosphoenolpyruvate carboxykinase pckA AlphaFold + ColabFold
4.1.1.49
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0004612Catalysis of the reaction: ATP + oxaloacetate = ADP + CO2 + H+ + phosphoenolpyruvate. GO:0017076Binding to a purine nucleotide, a compound consisting of a purine nucleoside esterified with (ortho)phosphate. +47 total
0.36 No Hit 0.0% —
3694 VK055_0084 phosphoribosylglycinamide formyltransferase 2 purT AlphaFold + ColabFold
6.3.1.21
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0009152The chemical reactions and pathways resulting in the formation of a purine ribonucleotide, a compound consisting of ribonucleoside (a purine base linked to a ribose sugar) esterified with a phosphate group at either the 3' or 5'-hydroxyl group of the sugar. GO:0004644Catalysis of the reaction: 10-formyltetrahydrofolate + N1-(5-phospho-D-ribosyl)glycinamide = tetrahydrofolate + N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide. +69 total
0.36 No Hit 0.0% —
3695 VK055_4124 putative peptidase AlphaFold + ColabFold –
GO:0004222Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. GO:0006508The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. +25 total
0.359 No Hit 0.0% —
3696 VK055_3409 PTS system, Lactose/Cellobiose specific IIA subunit AlphaFold + ColabFold –
GO:0009401The uptake and phosphorylation of specific carbohydrates from the extracellular environment; uptake and phosphorylation are coupled, making the PTS a link between the uptake and metabolism of sugars; phosphoenolpyruvate is the original phosphate donor; phosphoenolpyruvate passes the phosphate via a signal transduction pathway, to enzyme 1 (E1), which in turn passes it on to the histidine protein, HPr; the next step in the system involves sugar-specific membrane-bound complex, enzyme 2 (EII), which transports the sugar into the cell; it includes the sugar permease, which catalyzes the transport reactions; EII is usually divided into three different domains, EIIA, EIIB, and EIIC. GO:0046872Binding to a metal ion. GO:0016740Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2.
0.359 No Hit 0.0% —
3697 VK055_3168 prokaryotic lipoprotein-attachment site family protein AlphaFold + ColabFold –
GO:0009279A lipid bilayer that forms the outermost membrane of the cell envelope; enriched in polysaccharide and protein; the outer leaflet of the membrane contains specific lipopolysaccharide structures.
0.359 No Hit 0.0% —
3698 VK055_3144 tatA ColabFold – – 0.359 No Hit 0.0% —
3699 VK055_2171 xylose isomerase-like TIM barrel family protein AlphaFold + ColabFold –
GO:0016853Catalysis of the geometric or structural changes within one molecule. Isomerase is the systematic name for any enzyme of EC class 5.
0.359 No Hit 0.0% —
3700 VK055_2137 acyl-CoA thioesterase II tesB AlphaFold + ColabFold
3.1.2.20
GO:0047617Catalysis of the reaction: a fatty acyl-CoA + H2O = a fatty acid + CoA + H+. GO:0006637The chemical reactions and pathways involving acyl-CoA, any derivative of coenzyme A in which the sulfhydryl group is in thiolester linkage with an acyl group. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. +14 total
0.359 Hit 50.0% 1.30e-07
Page of 204 · 5081 total proteins