Proteins

Genome: KpATCC43816

Description: Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome

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# Protein Description Gene Structure EC GO Metabolism Druggability (P2Rank) P2RANK ligandability score for the best pocket in the experimental structure (0–1). Higher values indicate higher predicted ligandability. Available only for genomes analyzed with the curated pipeline. Druggability (FPocket) FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
3976 VK055_4844 nuoI nuoI AlphaFold DB model + ColabFold model
7.1.1.-
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0051539Binding to a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands. GO:0016651Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. +58 total
Mapped 3 0.179 0.372 Hit 47.9% 7.04e-07
3977 VK055_3375 hypothetical protein ColabFold model – – No map 0.179 0.083 No Hit 0.0% —
3978 VK055_3043 dgkA dgkA AlphaFold DB model + ColabFold model
2.7.1.107
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0008654The chemical reactions and pathways resulting in the formation of a phospholipid, a lipid containing phosphoric acid as a mono- or diester. GO:0008610The chemical reactions and pathways resulting in the formation of lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. +69 total
No map 0.179 0.837 No Hit 0.0% —
3979 VK055_1184 peptidase S49 family protein AlphaFold DB model + ColabFold model –
GO:0004252Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). GO:0008233Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid. GO:0006508The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds. +14 total
No map 0.179 0.659 No Hit 0.0% —
3980 VK055_5133 polymyxin resistance PmrD family protein AlphaFold DB model + ColabFold model – – No map 0.178 0.03 No Hit 0.0% —
3981 VK055_4611 DNA repair protein RecO recO AlphaFold DB model + ColabFold model –
GO:0006281The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. GO:0006310Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Interchromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction. GO:0043590The region of a bacterial cell to which the DNA is confined. +14 total
No map 0.178 0.686 No Hit 0.0% —
3982 VK055_4582 bamD AlphaFold DB model + ColabFold model –
GO:0005515Binding to a protein. GO:1990063Protein complex which is involved in assembly and insertion of beta-barrel proteins into the outer membrane. In E. coli it is composed of BamABCDE, of the outer membrane protein BamA, and four lipoproteins BamB, BamC, BamD and BamE. BamA interacts directly with BamB and the BamCDE subcomplex. GO:0043165The assembly of an outer membrane of the type formed in Gram-negative bacteria. This membrane is enriched in polysaccharide and protein, and the outer leaflet of the membrane contains specific lipopolysaccharide structures. +14 total
No map 0.178 0.367 No Hit 0.0% —
3983 VK055_4517 putative cytoplasmic protein AlphaFold DB model + ColabFold model – – No map N/A 0.178 No Hit 0.0% —
3984 VK055_3868 lptC yrbK AlphaFold DB model + ColabFold model –
GO:0015920The directed movement of lipopolysaccharides into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A lipopolysaccharide is any of a group of related, structurally complex components of the outer membrane of Gram-negative bacteria. Lipopolysaccharides consist three covalently linked regions, lipid A, core oligosaccharide, and an O side chain. Lipid A is responsible for the toxicity of the lipopolysaccharide. GO:0015221Enables the transfer of lipopolysaccharides from one side of a membrane to the other. A lipopolysaccharide is any of a group of related, structurally complex components of the outer membrane of Gram-negative bacteria. Lipopolysaccharides consist three covalently linked regions, lipid A, core oligosaccharide, and an O side chain. Lipid A is responsible for the toxicity of the lipopolysaccharide. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. +36 total
No map 0.178 0.211 No Hit 0.0% —
3985 VK055_2393 hypothetical protein AlphaFold DB model + ColabFold model –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
No map 0.178 0.734 No Hit 0.0% —
3986 VK055_2289 gram-negative pili assembly chaperone, C-terminal domain protein ColabFold model –
GO:0043711A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a pilus, a short filamentous structure on a bacterial cell, flagella-like in structure and generally present in many copies. GO:0030288The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin peptidoglycan layer (PGL), also referred to as a thin cell wall. GO:0071555A process that results in the assembly, arrangement of constituent parts, or disassembly of the cell wall, the rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. +14 total
No map 0.178 0.691 No Hit 0.0% —
3987 VK055_2134 putative dTDP-glucose pyrophosphorylase AlphaFold DB model + ColabFold model – – Chokepoint 1 N/A 0.178 No Hit 0.0% —
3988 VK055_0496 transcriptional regulator slyA slyA AlphaFold DB model + ColabFold model –
GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). +36 total
No map 0.178 0.685 No Hit 0.0% —
3989 VK055_4519 hypothetical protein AlphaFold DB model + ColabFold model – – No map N/A 0.177 No Hit 0.0% —
3990 VK055_4169 bacterial regulatory helix-turn-helix, lysR family protein AlphaFold DB model + ColabFold model –
GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0000976Binding to a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon.
No map 0.177 0.832 No Hit 0.0% —
3991 VK055_2725 HNH endonuclease family protein AlphaFold DB model + ColabFold model –
GO:0008270Binding to a zinc ion (Zn). GO:0004519Catalysis of the cleavage of ester linkages within nucleic acids by creating internal breaks. GO:0003676Binding to a nucleic acid.
No map 0.177 0.643 No Hit 0.0% —
3992 VK055_1852 amino ABC transporter, permease, 3-TM region, His/Glu/Gln/Arg/opine family domain protein AlphaFold DB model + ColabFold model –
GO:0043190A complex for the transport of metabolites into and out of the cell, typically comprised of four domains; two membrane-associated domains and two ATP-binding domains at the intracellular face of the membrane, that form a central pore through the plasma membrane. Each of the four core domains may be encoded as a separate polypeptide or the domains can be fused in any one of a number of ways into multidomain polypeptides. In Bacteria and Archaebacteria, ABC transporters also include substrate binding proteins to bind substrate external to the cytoplasm and deliver it to the transporter. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. +36 total
No map 0.177 0.891 No Hit 0.0% —
3993 VK055_1718 molybdopterin converting factor, subunit 1 moaD AlphaFold DB model + ColabFold model –
GO:0006777The chemical reactions and pathways resulting in the formation of the Mo-molybdopterin cofactor, essential for the catalytic activity of some enzymes. The cofactor consists of a mononuclear molybdenum (Mo) ion coordinated by one or two molybdopterin ligands.
No map N/A 0.177 No Hit 0.0% —
3994 VK055_0535 putative transferase AlphaFold DB model + ColabFold model –
GO:0016746Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor). GO:0016779Catalysis of the transfer of a nucleotidyl group from one compound (donor) to another (acceptor).
No map 0.177 0.357 No Hit 0.0% —
3995 VK055_4885 outer membrane protein C ompC4 Experimental + ColabFold model –
GO:0015288Enables the transfer of substances, sized less than 1000 Da, from one side of a membrane to the other. The transmembrane portions of porins consist exclusively of beta-strands which form a beta-barrel. They are found in the outer membranes of Gram-negative bacteria, mitochondria, plastids and possibly acid-fast Gram-positive bacteria. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0009279A lipid bilayer that forms the outermost membrane of the cell envelope; enriched in polysaccharide and protein; the outer leaflet of the membrane contains specific lipopolysaccharide structures. +25 total
No map 0.176 0.642 No Hit 0.0% —
3996 VK055_3584 hypothetical protein AlphaFold DB model + ColabFold model – – No map N/A 0.176 No Hit 0.0% —
3997 VK055_3383 putative dNA-binding transcriptional regulator AlphaFold DB model + ColabFold model –
GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.
No map 0.176 0.909 No Hit 0.0% —
3998 VK055_0903 hypothetical protein ColabFold model – – No map N/A 0.176 No Hit 0.0% —
3999 VK055_4806 hypothetical protein AlphaFold DB model + ColabFold model –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
No map 0.175 0.75 No Hit 0.0% —
4000 VK055_2753 hypothetical protein ColabFold model – – No map 0.175 0.735 No Hit 0.0% —
Page of 204 · 5081 total proteins