Proteins

Genome: KpATCC43816

Description: Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome

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# Protein Description Gene Structure EC GO Metabolism Druggability (P2Rank) P2RANK ligandability score for the best pocket in the experimental structure (0–1). Higher values indicate higher predicted ligandability. Available only for genomes analyzed with the curated pipeline. Druggability (FPocket) FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
4026 VK055_0422 binding-protein-dependent transport system innermembrane component family protein AlphaFold DB model + ColabFold model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. +14 total
No map 0.170 0.78 No Hit 0.0% —
4027 VK055_3843 periplasmic serine peptidase DegS degS AlphaFold DB model + ColabFold model
3.4.21.107
GO:0004252Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). GO:0006508The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds. GO:0005515Binding to a protein. +36 total
No map 0.169 0.322 Hit 36.9% 1.45e-18
4028 VK055_3522 pdhR transcriptional dual regulator pdhR2 AlphaFold DB model + ColabFold model –
GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
No map 0.169 0.138 No Hit 0.0% —
4029 VK055_1201 bacterial regulatory helix-turn-helix, lysR family protein AlphaFold DB model + ColabFold model –
GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0032993A macromolecular complex containing both protein and DNA molecules. +14 total
No map 0.169 0.663 No Hit 0.0% —
4030 VK055_1097 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.169 0.652 No Hit 0.0% —
4031 VK055_5179 structural protein 3 AlphaFold DB model + ColabFold model – – No map 0.168 0.68 No Hit 0.0% —
4032 VK055_3164 FMN phosphatase yigB AlphaFold DB model + ColabFold model –
GO:0016787Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. GO:0046872Binding to a metal ion. GO:0009231The chemical reactions and pathways resulting in the formation of riboflavin (vitamin B2), the precursor for the coenzymes flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD).
No map 0.168 0.344 Hit 24.7% 5.27e-11
4033 VK055_1101 type VI secretion system effector, Hcp1 family protein hcp1 AlphaFold DB model + ColabFold model – – No map 0.168 0.2 No Hit 0.0% —
4034 VK055_4830 yfbU domain protein AlphaFold DB model + ColabFold model – – No map 0.167 0.12 No Hit 0.0% —
4035 VK055_4217 arsenate reductase arsC AlphaFold DB model + ColabFold model –
GO:0008794Catalysis of the reaction: arsenate + reduced glutaredoxin = arsenite + oxidized glutaredoxin. Glutaredoxin functions as the electron donor for arsenate reduction. The electron flow therefore is ( NADPH -> glutathione reductase (EC:1.6.4.2) -> ) glutathione -> glutaredoxin -> arsenate reductase, i.e. glutathione is reduced by glutathione reductase and glutaredoxin is reduced by glutathione.
Chokepoint 4 N/A 0.167 No Hit 0.0% —
4036 VK055_2228 psiF repeat family protein AlphaFold DB model + ColabFold model – – No map 0.167 0.267 No Hit 0.0% —
4037 VK055_4920 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.166 0.296 No Hit 0.0% —
4038 VK055_4293 prepilin-type N-terminal cleavage/methylation domain protein AlphaFold DB model + ColabFold model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
No map N/A 0.166 No Hit 0.0% —
4039 VK055_3725 cyclophilin type peptidyl-prolyl cis-trans isomerase/CLD family protein AlphaFold DB model + ColabFold model
5.2.1.8
GO:0006457The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. GO:0000413The modification of a protein by cis-trans isomerization of a proline residue. GO:0003755Catalysis of the reaction: peptidyl-proline (omega=180) = peptidyl-proline (omega=0). +14 total
No map 0.166 0.631 Hit 44.2% 2.78e-09
4040 VK055_3656 death on curing protein doc AlphaFold DB model + ColabFold model –
GO:0016301Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule.
No map 0.166 0.522 No Hit 0.0% —
4041 VK055_2829 hypothetical protein AlphaFold DB model + ColabFold model – – No map N/A 0.166 No Hit 0.0% —
4042 VK055_1421 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.166 0.884 No Hit 0.0% —
4043 VK055_0382 CRISPR-associated protein Cas6/Cse3/CasE, subtype I-E/ECOLI cas6e AlphaFold DB model + ColabFold model – – No map 0.166 0.644 No Hit 0.0% —
4044 VK055_4700 nlpB/DapX lipofamily protein AlphaFold DB model + ColabFold model –
GO:0009279A lipid bilayer that forms the outermost membrane of the cell envelope; enriched in polysaccharide and protein; the outer leaflet of the membrane contains specific lipopolysaccharide structures. GO:0043165The assembly of an outer membrane of the type formed in Gram-negative bacteria. This membrane is enriched in polysaccharide and protein, and the outer leaflet of the membrane contains specific lipopolysaccharide structures. GO:0051205The process that results in the incorporation of a protein into a biological membrane. Incorporation in this context means having some part or covalently attached group that is inserted into the the hydrophobic region of one or both bilayers.
No map 0.165 0.558 No Hit 0.0% —
4045 VK055_4418 phenolic acid decarboxylase subunit B bsdB AlphaFold DB model + ColabFold model
2.5.1.129
GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0016831Catalysis of the nonhydrolytic addition or removal of a carboxyl group to or from a compound. GO:0106141Catalysis of the reaction: dimethylallyl phosphate + FMNH2 = phosphate + prenyl-FMNH2. +14 total
Chokepoint 4 0.165 0.547 No Hit 0.0% —
4046 VK055_3491 DNA repair RadC family protein AlphaFold DB model + ColabFold model –
GO:0046872Binding to a metal ion. GO:0008237Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. GO:0006508The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds.
No map 0.165 0.7 No Hit 0.0% —
4047 VK055_0901 competence/damage-inducible CinA C-terminal domain protein Experimental + ColabFold model – – No map 0.165 0.781 No Hit 0.0% —
4048 VK055_0198 intracellular multiplication and human macrophage-killing family protein icmF2 AlphaFold DB model + ColabFold model – – No map 0.164 0.688 No Hit 0.0% —
4049 VK055_4823 disulfide bond reductase AlphaFold DB model + ColabFold model –
GO:0015036Catalysis of the reaction: substrate with reduced sulfide groups = substrate with oxidized disulfide bonds.
No map 0.163 0.592 No Hit 0.0% —
4050 VK055_4098 hypothetical protein AlphaFold DB model + ColabFold model –
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
No map 0.163 0.485 No Hit 0.0% —
Page of 204 · 5081 total proteins