Proteins

Genome: KpATCC43816

Description: Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome

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5081 proteins

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# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
4026 VK055_2565 molybdopterin adenylyltransferase mog AlphaFold + ColabFold
2.7.7.75
GO:0006777The chemical reactions and pathways resulting in the formation of the Mo-molybdopterin cofactor, essential for the catalytic activity of some enzymes. The cofactor consists of a mononuclear molybdenum (Mo) ion coordinated by one or two molybdopterin ligands. GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0061598Catalysis of the reaction ATP + molybdopterin = diphosphate + adenylyl-molybdopterin.
0.296 Hit 40.0% 7.10e-18
4027 VK055_2422 sugar fermentation stimulation protein sfsA AlphaFold + ColabFold –
GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
0.296 No Hit 0.0% —
4028 VK055_1350 liporeleasing system, transmembrane, LolC/E family protein AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0042953The directed movement of any conjugated, water-soluble protein in which the nonprotein group consists of a lipid or lipids, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. GO:0098797Any protein complex that is part of the plasma membrane. +14 total
0.296 No Hit 0.0% —
4029 VK055_1013 succinylarginine dihydrolase astB AlphaFold + ColabFold
3.5.3.23
GO:0006525The chemical reactions and pathways involving arginine, 2-amino-5-(carbamimidamido)pentanoic acid. GO:0009015Catalysis of the reaction: N(2)-succinyl-L-arginine + 2 H2O + 2 H+ = N(2)-succinyl-L-ornithine + CO2 + 2 NH4. GO:0019544OBSOLETE. The chemical reactions and pathways resulting in the breakdown of L-arginine into other compounds, including L-glutamate. +14 total
0.296 No Hit 0.0% —
4030 VK055_0510 electron transport complex, RnfABCDGE type, G subunit AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0010181Binding to flavin mono nucleotide. Flavin mono nucleotide (FMN) is the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. GO:0022900A process in which a series of electron carriers operate together to transfer electrons from donors to any of several different terminal electron acceptors. +25 total
0.296 No Hit 0.0% —
4031 VK055_5183 hypothetical protein ColabFold – – 0.295 No Hit 0.0% —
4032 VK055_4707 transcriptional regulator, Spx/MgsR family protein AlphaFold + ColabFold – – 0.295 No Hit 0.0% —
4033 VK055_4576 hypothetical protein AlphaFold + ColabFold – – 0.295 No Hit 0.0% —
4034 VK055_2020 lysine-arginine-ornithine-binding periplasmic family protein AlphaFold + ColabFold –
GO:0030288The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin peptidoglycan layer (PGL), also referred to as a thin cell wall. GO:0071705The directed movement of nitrogen-containing compounds into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore.
0.295 No Hit 0.0% —
4035 VK055_0821 hydroxyisourate hydrolase uraH Experimental + ColabFold –
GO:0006144The chemical reactions and pathways involving purine nucleobases, one of the two classes of nitrogen-containing ring compounds found in DNA and RNA, which include adenine and guanine. GO:0033971Catalysis of the reaction: 5-hydroxyisourate + H2O = 5-hydroxy-2-oxo-4-ureido-2,5-dihydro-1H-imidazole-5-carboxylate + H+.
0.295 No Hit 0.0% —
4036 VK055_0751 PTS system, fructose subfamily, IIA component domain protein fruA AlphaFold + ColabFold –
GO:0009401The uptake and phosphorylation of specific carbohydrates from the extracellular environment; uptake and phosphorylation are coupled, making the PTS a link between the uptake and metabolism of sugars; phosphoenolpyruvate is the original phosphate donor; phosphoenolpyruvate passes the phosphate via a signal transduction pathway, to enzyme 1 (E1), which in turn passes it on to the histidine protein, HPr; the next step in the system involves sugar-specific membrane-bound complex, enzyme 2 (EII), which transports the sugar into the cell; it includes the sugar permease, which catalyzes the transport reactions; EII is usually divided into three different domains, EIIA, EIIB, and EIIC. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0008982Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + sugar(out) = protein histidine + sugar phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport.
0.295 No Hit 0.0% —
4037 VK055_0177 putative cold-shock protein AlphaFold + ColabFold –
GO:0003676Binding to a nucleic acid.
0.295 No Hit 0.0% —
4038 VK055_4105 hypothetical protein AlphaFold + ColabFold – – 0.294 No Hit 0.0% —
4039 VK055_3699 molecular chaperone Hsp33 hslO AlphaFold + ColabFold –
GO:0006457The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. GO:0051082Binding to an unfolded protein. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. +25 total
0.294 No Hit 0.0% —
4040 VK055_3572 dppF AlphaFold + ColabFold –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0015833The directed movement of peptides, compounds of two or more amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. GO:0000166Binding to a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose. +25 total
0.294 Hit 39.1% 6.48e-08
4041 VK055_2258 bacterial extracellular solute-binding, 3 familyprotein AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0015276Enables the transmembrane transfer of an ion by a channel that opens when a specific ligand has been bound by the channel complex or one of its constituent parts. GO:0005576The space external to the outermost structure of a cell. For cells without external protective or external encapsulating structures this refers to space outside of the plasma membrane. This term covers the host cell environment outside an intracellular parasite. +25 total
0.294 Hit 42.5% 2.33e-06
4042 VK055_2158 hypothetical protein AlphaFold + ColabFold – – 0.294 No Hit 0.0% —
4043 VK055_1856 filamentous hemagglutinin family N-terminal domain protein AlphaFold + ColabFold – – 0.294 No Hit 0.0% —
4044 VK055_0611 2-halobenzoate 1,2-dioxygenase large subunit cbdA AlphaFold + ColabFold –
GO:0044237OBSOLETE. The chemical reactions and pathways by which individual cells transform chemical substances. GO:0051537Binding to a 2 iron, 2 sulfur (2Fe-2S) cluster; this cluster consists of two iron atoms, with two inorganic sulfur atoms found between the irons and acting as bridging ligands. GO:0005506Binding to an iron (Fe) ion. +14 total
0.294 No Hit 0.0% —
4045 VK055_0324 cysteine desulfuration protein sufE sufE AlphaFold + ColabFold –
GO:0016226The incorporation of iron and exogenous sulfur into a metallo-sulfur cluster. GO:0006790The chemical reactions and pathways involving the nonmetallic element sulfur or compounds that contain sulfur, such as the amino acids methionine and cysteine or the tripeptide glutathione. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
0.294 No Hit 0.0% —
4046 VK055_5147 hypothetical protein AlphaFold + ColabFold – – 0.293 No Hit 0.0% —
4047 VK055_4797 hypothetical protein AlphaFold + ColabFold – – 0.293 No Hit 0.0% —
4048 VK055_4727 ethanolamine ammonia-lyase, putative regulatory subunit AlphaFold + ColabFold
4.3.1.7
GO:0006520The chemical reactions and pathways involving amino acids, carboxylic acids containing one or more amino groups. GO:0008851Catalysis of the reaction: ethanolamine = acetaldehyde + NH4+. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. +47 total
0.293 No Hit 0.0% —
4049 VK055_4352 gcvA transcriptional dual regulator gcvA2 AlphaFold + ColabFold –
GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0043565Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. +14 total
0.293 No Hit 0.0% —
4050 VK055_3260 superoxide dismutase (Mn) sodA AlphaFold + ColabFold
1.15.1.1
GO:0004784Catalysis of the reaction: 2 superoxide + 2 H+ = O2 + H2O2. GO:0006801The chemical reactions and pathways involving superoxide, the superoxide anion O2- (superoxide free radical), or any compound containing this species. GO:0046872Binding to a metal ion. +25 total
0.293 Hit 54.3% 2.07e-11
Page of 204 · 5081 total proteins