Proteins

Genome: KpATCC43816

Description: Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome

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# Protein Description Gene Structure EC GO Metabolism Druggability (P2Rank) P2RANK ligandability score for the best pocket in the experimental structure (0–1). Higher values indicate higher predicted ligandability. Available only for genomes analyzed with the curated pipeline. Druggability (FPocket) FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
401 VK055_0777 cytochrome d ubiquinol oxidase, subunit II cydB3 AlphaFold DB model + ColabFold model
1.10.3.-
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0070069A protein complex in which at least one of the proteins is a cytochrome, i.e. a heme-containing protein involved in catalysis of redox reactions. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. +36 total
No map 0.959 0.937 No Hit 0.0% —
402 VK055_0469 short chain dehydrogenase family protein AlphaFold DB model + ColabFold model –
GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. GO:0008667Catalysis of the reaction: (2S,3S)-2,3-dihydroxy-2,3-dihydrobenzoate + NAD+ = 2,3-dihydroxybenzoate + H+ + NADH. GO:0019290The chemical reactions and pathways resulting in the formation of siderophores, low molecular weight Fe(III)-chelating substances made by aerobic or facultatively anaerobic bacteria, especially when growing under iron deficient conditions. The complexes of Fe(3+)-siderophores have very high stability constants and are taken up by specific transport systems by microorganisms; the subsequent release of iron requires enzymatic action.
No map 0.959 0.21 Hit 38.0% 3.94e-10
403 VK055_0017 eamA-like transporter family protein AlphaFold DB model + ColabFold model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
No map 0.959 0.988 No Hit 0.0% —
404 VK055_3534 alpha amylase, catalytic domain protein Experimental + ColabFold model
3.2.1.98
GO:0005975The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. GO:0042597The region between the inner (cytoplasmic) and outer membrane (Gram-negative Bacteria) or cytoplasmic membrane and cell wall (Fungi and Gram-positive Bacteria). GO:0004556Catalysis of the endohydrolysis of (1->4)-alpha-D-glucosidic linkages in polysaccharides containing three or more alpha-(1->4)-linked D-glucose units. +47 total
No map 0.958 0.846 Hit 28.0% 7.87e-06
405 VK055_2378 di-trans,poly-cis-decaprenylcistransferase uppS AlphaFold DB model + ColabFold model
2.5.1.31
GO:0016765Catalysis of the transfer of an alkyl or aryl (but not methyl) group from one compound (donor) to another (acceptor). GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0008834Catalysis of the reaction: (2E,6E)-farnesyl diphosphate + 8 isopentenyl diphosphate = di-trans,octa-cis-undecaprenyl diphosphate + 8 diphosphate. +58 total
Mapped 1 0.958 0.863 Hit 42.9% 3.12e-10
406 VK055_1952 betaine aldehyde dehydrogenase betB Experimental + ColabFold model
1.2.1.8
GO:0016620Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces NAD or NADP. GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. GO:0046872Binding to a metal ion. +25 total
Mapped 4 0.958 0.692 Hit 53.1% 3.58e-08
407 VK055_1178 GTP cyclohydrolase II ribA AlphaFold DB model + ColabFold model
3.5.4.25
GO:0003935Catalysis of the reaction: GTP + 4 H2O = 2,5-diamino-6-hydroxy-4-(5-phosphoribosylamino)-pyrimidine + formate + 3 H+ + 2 phosphate. GO:0009231The chemical reactions and pathways resulting in the formation of riboflavin (vitamin B2), the precursor for the coenzymes flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD). GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. +25 total
Chokepoint 1 0.958 0.645 No Hit 0.0% —
408 VK055_0667 sugar (and other) transporter family protein AlphaFold DB model + ColabFold model –
GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. +25 total
No map 0.958 0.391 Hit 28.3% 1.92e-09
409 VK055_0406 diacetyl reductase (S-acetoin forming) budC Experimental + ColabFold model
1.1.1.304
GO:0045150The chemical reactions and pathways resulting in the breakdown of acetoin, 3-hydroxy-2-butanone. GO:0019152Catalysis of the reaction: acetoin + NAD+ = diacetyl + NADH + H+. This reaction is catalyzed in the reverse direction. GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. +14 total
Chokepoint 1 0.958 0.457 Hit 41.9% 7.64e-11
410 VK055_3853 glutamate synthase (NADPH) large chain glutamatesynthase, large subunit AlphaFold DB model + ColabFold model
1.4.1.13
GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. GO:0015930Catalysis of the formation of L-glutamine and 2-oxoglutarate from L-glutamate, using NADH, NADPH or ferredoxin as hydrogen acceptors. GO:0006537OBSOLETE. The chemical reactions and pathways resulting in the formation of glutamate, the anion of 2-aminopentanedioic acid. +69 total
Mapped 1 0.957 0.868 No Hit 0.0% —
411 VK055_2815 6-phospho-beta-glucosidase AlphaFold DB model + ColabFold model –
GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0004553Catalysis of the hydrolysis of any O-glycosyl bond. GO:0005975The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. +25 total
Chokepoint 20 0.957 0.414 No Hit 0.0% —
412 VK055_2087 calcineurin-like phosphoesterase family protein AlphaFold DB model + ColabFold model –
GO:0009166The chemical reactions and pathways resulting in the breakdown of nucleotides, any nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the glycose moiety; may be mono-, di- or triphosphate; this definition includes cyclic-nucleotides (nucleoside cyclic phosphates). GO:0016788Catalysis of the hydrolysis of any ester bond. GO:0046872Binding to a metal ion. +25 total
No map 0.957 0.968 Hit 29.8% 1.49e-12
413 VK055_1858 leucine--tRNA ligase leuS AlphaFold DB model + ColabFold model
6.1.1.4
GO:0002161The hydrolysis of an incorrectly aminoacylated tRNA. GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0004812Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of diphosphate and AMP. +58 total
Chokepoint 3 0.957 0.782 Hit 73.0% 9.14e-12
414 VK055_1463 transporter, betaine/carnitine/choline transporter family protein AlphaFold DB model + ColabFold model –
GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0071705The directed movement of nitrogen-containing compounds into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. +14 total
No map 0.957 0.893 No Hit 0.0% —
415 VK055_0843 trans-aconitate 2-methyltransferase tam AlphaFold DB model + ColabFold model
2.1.1.144
GO:0030798Catalysis of the reaction: S-adenosyl-L-methionine + trans-aconitate = (E)-3-(methoxycarbonyl)pent-2-enedioate + S-adenosyl-L-homocysteine. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0032259The process in which a methyl group is covalently attached to a molecule.
Mapped 1 0.957 0.978 No Hit 0.0% —
416 VK055_0702 hypothetical protein ColabFold model –
GO:0016810Catalysis of the hydrolysis of any carbon-nitrogen bond, C-N, with the exception of peptide bonds. GO:0005975The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y.
No map 0.957 0.62 No Hit 0.0% —
417 VK055_0273 hexose kinase, 1-phosphofructokinase family protein AlphaFold DB model + ColabFold model –
GO:0016773Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to an alcohol group (acceptor). GO:0016301Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. GO:0005975The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. +36 total
No map 0.957 0.925 No Hit 0.0% —
418 VK055_5019 glycosyl transferases group 1 family protein AlphaFold DB model + ColabFold model –
GO:0016757Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor).
No map 0.956 0.152 Hit 37.3% 6.01e-07
419 VK055_4674 SEC-C motif family protein ColabFold model – – No map 0.956 0.894 No Hit 0.0% —
420 VK055_4289 thymidylate synthase thyA AlphaFold DB model + ColabFold model
2.1.1.45
GO:0004799Catalysis of the reaction: 5,10-methylenetetrahydrofolate + dUMP = 7,8-dihydrofolate + thymidylate. GO:0016741Catalysis of the transfer of a one-carbon group from one compound (donor) to another (acceptor). GO:0006231The chemical reactions and pathways resulting in the formation of dTMP, deoxyribosylthymine monophosphate (2'-deoxyribosylthymine 5'-phosphate). +36 total
Chokepoint 1 0.956 0.307 Hit 50.7% 1.02e-95
421 VK055_4172 sugar (and other) transporter family protein AlphaFold DB model + ColabFold model –
GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
No map 0.956 0.838 No Hit 0.0% —
422 VK055_3273 lacY lactose MFS transporter lacY4 AlphaFold DB model + ColabFold model –
GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0008643The directed movement of carbohydrate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Carbohydrates are a group of organic compounds based of the general formula Cx(H2O)y. +47 total
No map 0.956 0.709 No Hit 0.0% —
423 VK055_2958 stbA family protein AlphaFold DB model + ColabFold model – – No map 0.956 0.628 No Hit 0.0% —
424 VK055_1811 deoxyribodipyrimidine photolyase AlphaFold DB model + ColabFold model
4.1.99.3
GO:0003904Catalysis of the reaction: cyclobutadipyrimidine (in DNA) = 2 pyrimidine residues (in DNA). This reaction represents the reactivation of irradiated DNA by light. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0071949Binding to the oxidized form, FAD, of flavin-adenine dinucleotide, the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. +25 total
No map 0.956 0.867 Hit 28.2% 5.15e-42
425 VK055_1729 putative methyltransferase, enzyme of biotin synthesis AlphaFold DB model + ColabFold model
2.1.1.197
GO:0008168Catalysis of the transfer of a methyl group to an acceptor molecule. GO:0009102The chemical reactions and pathways resulting in the formation of biotin, cis-tetrahydro-2-oxothieno(3,4-d)imidazoline-4-valeric acid. GO:0010340Catalysis of the transfer of a methyl group to the carboxyl group of an acceptor molecule to form a methyl ester. +36 total
No map 0.956 0.828 Hit 25.3% 1.96e-09
Page of 204 · 5081 total proteins