Proteins

Genome: KpATCC43816

Description: Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome

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5081 proteins

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# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
676 VK055_1002 putative inner membrane protein AlphaFold + ColabFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
0.902 No Hit 0.0% —
677 VK055_4038 1-acylglycerol-3-phosphate O-acyltransferases domain protein AlphaFold + ColabFold
2.3.1.51
GO:0003841Catalysis of the reaction: acyl-CoA + 1-acyl-sn-glycerol-3-phosphate = CoA + 1,2-diacyl-sn-glycerol-3-phosphate. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0008654The chemical reactions and pathways resulting in the formation of a phospholipid, a lipid containing phosphoric acid as a mono- or diester. +47 total
0.901 Hit 29.9% 1.26e-32
678 VK055_2666 yfaZ family protein AlphaFold + ColabFold – – 0.901 No Hit 0.0% —
679 VK055_1712 inner membrane YbhQ family protein ColabFold – – 0.901 No Hit 0.0% —
680 VK055_1235 succinylglutamic semialdehyde dehydrogenase astD2 AlphaFold + ColabFold
1.2.1.71
GO:0043824Catalysis of the reaction: N-succinyl-L-glutamate 5-semialdehyde + H2O + NAD+ = N-succinyl-L-glutamate + 2 H+ + NADH. GO:0016620Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces NAD or NADP. GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. +36 total
0.901 Hit 34.4% 1.49e-06
681 VK055_1131 hypothetical protein AlphaFold + ColabFold – – 0.901 No Hit 0.0% —
682 VK055_1118 glycosyl transferase 2 family protein AlphaFold + ColabFold –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0016758Catalysis of the transfer of a hexosyl group from one compound (donor) to another (acceptor).
0.901 No Hit 0.0% —
683 VK055_0922 dimethyl sulfoxide reductase, chain C AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0019645A process in which a series of electron carriers operate together to transfer electrons from donors such as NADH and FADH2 to any of several different terminal electron acceptors other than oxygen to generate a transmembrane electrochemical gradient. GO:0009390An enzyme complex that catalyzes the formation of dimethyl sulfide from dimethyl sulfoxide. +25 total
0.901 No Hit 0.0% —
684 VK055_2019 aldo/keto reductase family protein AlphaFold + ColabFold –
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.
0.9 Hit 35.5% 5.34e-10
685 VK055_0069 DNA-binding regulatory, YebC/PmpR family protein AlphaFold + ColabFold –
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
0.9 Hit 31.2% 2.73e-32
686 VK055_4619 phosphoribosylformylglycinamidine synthase purL AlphaFold + ColabFold
6.3.5.3
GO:0006189The chemical reactions and pathways resulting in the formation of IMP, inosine monophosphate, by the stepwise assembly of a purine ring on ribose 5-phosphate. GO:0004642Catalysis of the reaction: N(2)-formyl-N(1)-(5-phospho-D-ribosyl)glycinamide + L-glutamine + ATP + H2O = 2-(formamido)-N(1)-(5-phospho-D-ribosyl)acetamidine + L-glutamate + ADP + 2 H+ + phosphate. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. +25 total
0.899 Hit 46.5% 1.58e-06
687 VK055_3911 luciferase oxidoreductase, group 1 family protein AlphaFold + ColabFold –
GO:0016705Catalysis of an oxidation-reduction (redox) reaction in which hydrogen or electrons are transferred from each of two donors, and molecular oxygen is reduced or incorporated into a donor. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
0.899 No Hit 0.0% —
688 VK055_2292 bacterial regulatory, luxR family protein AlphaFold + ColabFold –
GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0005515Binding to a protein. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
0.899 No Hit 0.0% —
689 VK055_5025 undecaprenyl-phosphate glucose phosphotransferase wcaJ AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0089702Catalysis of the reaction: di-trans,octa-cis-undecaprenyl phosphate + UDP-alpha-D-glucose = alpha-D-glucosyl di-trans,octa-cis-undecaprenyl diphosphate + UMP. GO:0009242The chemical reactions and pathways resulting in the formation of colanic acid, a capsular bacterial polysaccharide.
0.898 No Hit 0.0% —
690 VK055_2470 secretion monitor family protein AlphaFold + ColabFold –
GO:0045182Any molecular function involved in the regulation of initiation, activation, perpetuation, repression or termination of polypeptide synthesis at the ribosome. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0042597The region between the inner (cytoplasmic) and outer membrane (Gram-negative Bacteria) or cytoplasmic membrane and cell wall (Fungi and Gram-positive Bacteria).
0.898 No Hit 0.0% —
691 VK055_0662 bacterial regulatory helix-turn-helix, AraC family protein AlphaFold + ColabFold –
GO:0043565Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
0.898 No Hit 0.0% —
692 VK055_5013 PAP2 superfamily protein AlphaFold + ColabFold – – 0.897 No Hit 0.0% —
693 VK055_4009 acyl-phosphate glycerol 3-phosphate acyltransferase plsY AlphaFold + ColabFold
2.3.1.275
GO:0043772Catalysis of the reaction: acyl phosphate + sn-glycerol 3-phosphate = 1-acyl-sn-glycerol 3-phosphate + orthophosphate. GO:0008654The chemical reactions and pathways resulting in the formation of a phospholipid, a lipid containing phosphoric acid as a mono- or diester. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
0.897 No Hit 0.0% —
694 VK055_3818 mreB mreB AlphaFold + ColabFold –
GO:0000902The developmental process in which the size or shape of a cell is generated and organized. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. +14 total
0.897 Hit 29.6% 1.11e-07
695 VK055_3076 iclR transcriptional repressor iclR AlphaFold + ColabFold –
GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. +14 total
0.897 No Hit 0.0% —
696 VK055_3054 phosphate-starvation-inducible E family protein AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0016036Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of deprivation of phosphate. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
0.897 No Hit 0.0% —
697 VK055_1117 opgC family protein ColabFold – – 0.897 No Hit 0.0% —
698 VK055_0764 branched-chain amino acid transport system / permease component family protein AlphaFold + ColabFold –
GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. +14 total
0.897 No Hit 0.0% —
699 VK055_4376 putative oxidoreductase ygdH AlphaFold + ColabFold
3.2.2.10 3.2.2.4
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0008714Catalysis of the reaction: AMP + H2O = D-ribose 5-phosphate + adenine. GO:0047405Catalysis of the reaction: H2O + a pyrimidine 5'-nucleotide = ribose-5-phosphate + a pyrimidine.
0.896 No Hit 0.0% —
700 VK055_4216 arsB arsB AlphaFold + ColabFold –
GO:0015700The directed movement of arsenite into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0015105Enables the transfer of arsenite from one side of a membrane to the other. +47 total
0.896 No Hit 0.0% —
Page of 204 · 5081 total proteins