Proteins

Genome: KpATCC43816

Description: Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome

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# Protein Description Gene Structure EC GO Metabolism Druggability (P2Rank) P2RANK ligandability score for the best pocket in the experimental structure (0–1). Higher values indicate higher predicted ligandability. Available only for genomes analyzed with the curated pipeline. Druggability (FPocket) FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
976 VK055_1668 molybdopterin synthase sulfurylase MoeB moeB AlphaFold DB model + ColabFold model
2.7.7.80
GO:0006777The chemical reactions and pathways resulting in the formation of the Mo-molybdopterin cofactor, essential for the catalytic activity of some enzymes. The cofactor consists of a mononuclear molybdenum (Mo) ion coordinated by one or two molybdopterin ligands. GO:0008641Catalysis of the activation of small proteins, such as ubiquitin or ubiquitin-like proteins, through the formation of an ATP-dependent high-energy thiolester bond. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. +47 total
Chokepoint 1 0.899 0.13 Hit 47.9% 2.07e-07
977 VK055_1226 PTS system, cellobiose-specific IIC component celB AlphaFold DB model + ColabFold model –
GO:0009401The uptake and phosphorylation of specific carbohydrates from the extracellular environment; uptake and phosphorylation are coupled, making the PTS a link between the uptake and metabolism of sugars; phosphoenolpyruvate is the original phosphate donor; phosphoenolpyruvate passes the phosphate via a signal transduction pathway, to enzyme 1 (E1), which in turn passes it on to the histidine protein, HPr; the next step in the system involves sugar-specific membrane-bound complex, enzyme 2 (EII), which transports the sugar into the cell; it includes the sugar permease, which catalyzes the transport reactions; EII is usually divided into three different domains, EIIA, EIIB, and EIIC. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0008982Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + sugar(out) = protein histidine + sugar phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport. +25 total
No map 0.899 0.626 No Hit 0.0% —
978 VK055_2571 homoserine kinase thrB AlphaFold DB model + ColabFold model
2.7.1.39
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0006566The chemical reactions and pathways involving threonine (2-amino-3-hydroxybutyric acid), a polar, uncharged, essential amino acid found in peptide linkage in proteins. GO:0004413Catalysis of the reaction: L-homoserine + ATP = O-phospho-L-homoserine + ADP + 2 H+. +25 total
Chokepoint 1 0.898 0.651 No Hit 0.0% —
979 VK055_2470 secretion monitor family protein AlphaFold DB model + ColabFold model –
GO:0045182Any molecular function involved in the regulation of initiation, activation, perpetuation, repression or termination of polypeptide synthesis at the ribosome. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0042597The region between the inner (cytoplasmic) and outer membrane (Gram-negative Bacteria) or cytoplasmic membrane and cell wall (Fungi and Gram-positive Bacteria).
No map N/A 0.898 No Hit 0.0% —
980 VK055_1459 gamma-glutamyl-gamma-aminobutyraldehyde dehydrogenase AlphaFold DB model + ColabFold model –
GO:0016620Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces NAD or NADP. GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. GO:0004030Catalysis of the reaction: an aldehyde + NAD(P)+ + H2O = an acid + NAD(P)H + H+.
Mapped 2 0.898 0.507 Hit 54.3% 1.10e-07
981 VK055_0738 bacterial regulatory, tetR family protein AlphaFold DB model + ColabFold model –
GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
No map 0.898 0.675 No Hit 0.0% —
982 VK055_0636 malate dehydrogenase, NAD-requiring AlphaFold DB model + ColabFold model
1.1.1.38
GO:0051287Binding to nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD+, or the reduced form, NADH. GO:0004471Catalysis of the reaction: (S)-malate + NAD+ = pyruvate + CO2 + NADH. GO:0004470Catalysis of the oxidative decarboxylation of malate with the concomitant production of pyruvate. +47 total
Mapped 3 0.898 0.636 Hit 48.6% 9.06e-81
983 VK055_4476 short chain dehydrogenase family protein AlphaFold DB model + ColabFold model –
GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. GO:0016616Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP.
No map 0.897 0.784 Hit 35.5% 5.54e-06
984 VK055_2000 xylose isomerase-like TIM barrel family protein AlphaFold DB model + ColabFold model – – No map 0.897 0.203 No Hit 0.0% —
985 VK055_1276 bacterial regulatory helix-turn-helix, lysR family protein AlphaFold DB model + ColabFold model –
GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0043565Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. +14 total
No map 0.897 0.845 No Hit 0.0% —
986 VK055_0978 NAD(P)(+) transhydrogenase (AB-specific), alpha subunit pntA AlphaFold DB model + ColabFold model
7.1.1.1
GO:1902600The directed movement of a proton across a membrane. GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. GO:0008746OBSOLETE. Catalysis of the reaction: NADPH + H+ + NAD+ = NADP+ + NADH + H+. +47 total
No map 0.897 0.829 Hit 57.4% 1.22e-10
987 VK055_0410 beta-D-hydroxybutyrate dehydrogenase bdhA AlphaFold DB model + ColabFold model –
GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. GO:0003858Catalysis of the reaction: (R)-3-hydroxybutanoate + NAD+ = acetoacetate + H+ + NADH.
Mapped 1 0.897 0.859 Hit 38.2% 4.17e-14
988 VK055_4636 inositol monophosphatase, putative mRNA turnover protein suhB AlphaFold DB model + ColabFold model
3.1.3.25
GO:0008934Catalysis of the reaction: 1D-myo-inositol 1-phosphate + H2O = myo-inositol + phosphate. GO:0046854The chemical reactions and pathways resulting in the formation of phosphatidylinositol phosphate. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. +69 total
No map 0.896 0.463 Hit 44.1% 1.44e-13
989 VK055_4275 6-phospho-beta-glucosidase gmuD gmuD AlphaFold DB model + ColabFold model –
GO:0004553Catalysis of the hydrolysis of any O-glycosyl bond. GO:0005975The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. +25 total
Chokepoint 20 0.896 0.482 Hit 29.9% 4.29e-11
990 VK055_3597 inner membrane protein YhjD yhjD AlphaFold DB model + ColabFold model –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
No map 0.896 0.976 No Hit 0.0% —
991 VK055_3470 guanosine-3',5'-bis(diphosphate) 3'-pyrophosphohydrolase spoT AlphaFold DB model + ColabFold model
3.1.7.2
GO:0015969The chemical reactions and pathways involving guanine tetraphosphate (5'-ppGpp-3'), a derivative of guanine riboside with four phosphates. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0008728Catalysis of the reaction: ATP + GTP = AMP + guanosine 3'-diphosphate 5'-triphosphate. +47 total
Chokepoint 2 0.896 0.313 Hit 37.8% 6.03e-12
992 VK055_2005 feaB AlphaFold DB model + ColabFold model –
GO:0016620Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces NAD or NADP. GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.
Chokepoint 1 0.896 0.947 Hit 41.5% 1.36e-47
993 VK055_1978 efflux pump membrane transporter BepE bepE AlphaFold DB model + ColabFold model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. +25 total
No map 0.896 0.984 No Hit 0.0% —
994 VK055_0698 permease for cytosine/purines, uracil, thiamine,allantoin family protein AlphaFold DB model + ColabFold model –
GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. +25 total
No map 0.896 0.685 No Hit 0.0% —
995 VK055_4677 type I phosphodiesterase / nucleotide pyrophosphatase family protein AlphaFold DB model + ColabFold model –
GO:0008484Catalysis of the reaction: RSO-R' + H2O = RSOOH + R'H. This reaction is the hydrolysis of a sulfuric ester bond, an ester formed from sulfuric acid, O=SO(OH)2. GO:0004065Catalysis of the reaction: a phenol sulfate + H2O = a phenol + sulfate. GO:0015024Catalysis of the hydrolysis of the 2-sulfate groups of the 2-O-sulfo-D-glucuronate residues of chondroitin sulfate, heparin and heparitin sulfate.
No map 0.895 0.756 Hit 32.4% 6.78e-06
996 VK055_4444 hypothetical protein AlphaFold DB model + ColabFold model
3.2.1.78
GO:0030246Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates. GO:0004553Catalysis of the hydrolysis of any O-glycosyl bond. GO:0005515Binding to a protein. +25 total
No map 0.895 0.513 No Hit 0.0% —
997 VK055_3430 bacterial regulatory, tetR family protein AlphaFold DB model + ColabFold model –
GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0000976Binding to a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon.
No map 0.895 0.63 No Hit 0.0% —
998 VK055_3364 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.895 0.931 No Hit 0.0% —
999 VK055_3221 tonB-dependent vitamin B12 receptor btuB AlphaFold DB model + ColabFold model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0015889The directed movement of cobalamin (vitamin B12), a water-soluble vitamin characterized by possession of a corrin nucleus containing a cobalt atom, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. GO:0015420Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: vitamin B12(out) + ATP + H2O = ADP + an vitamin B12(in) + H+ + phosphate. Vitamin B12 is alkylcob(III)alamin. +58 total
No map 0.895 0.495 No Hit 0.0% —
1000 VK055_2973 phosphonate metabolism protein PhnM phnM AlphaFold DB model + ColabFold model –
GO:0016810Catalysis of the hydrolysis of any carbon-nitrogen bond, C-N, with the exception of peptide bonds. GO:0019700The chemical reactions and pathways resulting in the breakdown of phosphonates, any organic compound containing one or more C-PO(OH)2 or C-PO(OR)2 (with R=alkyl, aryl) groups. Catabolism of phosphonic acid itself, an inorganic compound without the biochemically relevant C-P bond, is not included.
No map 0.895 0.34 No Hit 0.0% —
Page of 204 · 5081 total proteins