Proteins

Genome: KpATCC43816

Description: Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome

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# Protein Description Gene Structure EC GO Metabolism Druggability (P2Rank) P2RANK ligandability score for the best pocket in the experimental structure (0–1). Higher values indicate higher predicted ligandability. Available only for genomes analyzed with the curated pipeline. Druggability (FPocket) FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
1001 VK055_2738 putative atpase involved in dna repair AlphaFold DB model + ColabFold model – – No map 0.895 0.268 No Hit 0.0% —
1002 VK055_2146 queuosine biosynthesis protein QueC queC AlphaFold DB model + ColabFold model
6.3.4.20
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016879Catalysis of the joining of two molecules, or two groups within a single molecule, via a carbon-nitrogen bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate. GO:0008270Binding to a zinc ion (Zn). +14 total
No map 0.895 0.539 No Hit 0.0% —
1003 VK055_1071 tyrosine aminotransferase tyrB AlphaFold DB model + ColabFold model
2.6.1.-
GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0009058A cellular process consisting of the biochemical pathways by which a living organism synthesizes chemical substances. This typically represents the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. GO:0008483Catalysis of the transfer of an amino group to an acceptor, usually a 2-oxo acid. +69 total
Mapped 6 0.895 0.573 Hit 40.4% 2.19e-100
1004 VK055_1056 ferredoxin (flavodoxin) oxidoreductase nifJ AlphaFold DB model + ColabFold model
1.2.7.-
GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. GO:0016903Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor. +58 total
Mapped 1 0.895 0.964 No Hit 0.0% —
1005 VK055_0705 hypothetical protein AlphaFold DB model + ColabFold model – – No map N/A 0.895 No Hit 0.0% —
1006 VK055_4886 apbE family protein AlphaFold DB model + ColabFold model
2.7.1.180
GO:0017013The addition of a flavin group to a protein amino acid. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0046872Binding to a metal ion. +14 total
No map 0.894 0.49 No Hit 0.0% —
1007 VK055_4685 phosphoribosylglycinamide formyltransferase purN AlphaFold DB model + ColabFold model
2.1.2.2
GO:0009058A cellular process consisting of the biochemical pathways by which a living organism synthesizes chemical substances. This typically represents the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. GO:0004644Catalysis of the reaction: 10-formyltetrahydrofolate + N1-(5-phospho-D-ribosyl)glycinamide = tetrahydrofolate + N2-formyl-N1-(5-phospho-D-ribosyl)glycinamide. GO:0006189The chemical reactions and pathways resulting in the formation of IMP, inosine monophosphate, by the stepwise assembly of a purine ring on ribose 5-phosphate. +14 total
Mapped 1 0.894 0.601 Hit 44.0% 1.32e-35
1008 VK055_2917 blc outer membrane lipoprotein blc2 AlphaFold DB model + ColabFold model –
GO:0009279A lipid bilayer that forms the outermost membrane of the cell envelope; enriched in polysaccharide and protein; the outer leaflet of the membrane contains specific lipopolysaccharide structures. GO:0008289Binding to a lipid. GO:0006950Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation).
No map 0.894 0.518 Hit 33.6% 2.02e-07
1009 VK055_2689 tryptophan--tRNA ligase trpS AlphaFold DB model + ColabFold model
6.1.1.2
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0006436The process of coupling tryptophan to tryptophanyl-tRNA, catalyzed by tryptophanyl-tRNA synthetase. The tryptophanyl-tRNA synthetase is a class-I synthetase. The activated amino acid is transferred to the 2'-OH group of a tryptophan-accetping tRNA. The 2'-O-aminoacyl-tRNA will ultimately migrate to the 3' position via transesterification. GO:0004812Catalysis of the formation of aminoacyl-tRNA from ATP, amino acid, and tRNA with the release of diphosphate and AMP. +47 total
Chokepoint 3 0.894 0.265 Hit 27.7% 2.44e-25
1010 VK055_1579 hypothetical protein AlphaFold DB model + ColabFold model –
GO:0015661Enables the transfer of L-lysine from the inside of the cell to the outside of the cell across a membrane. GO:1903401The directed movement of L-lysine across a membrane.
No map 0.894 0.343 No Hit 0.0% —
1011 VK055_1115 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.894 0.566 No Hit 0.0% —
1012 VK055_1082 nmrA-like family protein AlphaFold DB model + ColabFold model –
GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.
No map 0.894 0.49 No Hit 0.0% —
1013 VK055_4602 putative S-adenosyl-L-methionine-dependent methyltransferase AlphaFold DB model + ColabFold model
2.1.1.223
GO:0016430OBSOLETE. Catalysis of the reaction: S-adenosyl-L-methionine + tRNA = S-adenosyl-L-homocysteine + tRNA containing N6-methyladenine. GO:0008168Catalysis of the transfer of a methyl group to an acceptor molecule. GO:0003676Binding to a nucleic acid. +36 total
No map 0.893 0.623 No Hit 0.0% —
1014 VK055_3623 UDP-L-Ara4O C-4' transaminase arnB AlphaFold DB model + ColabFold model
2.6.1.87
GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0008483Catalysis of the transfer of an amino group to an acceptor, usually a 2-oxo acid. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. +58 total
Chokepoint 1 0.893 0.56 No Hit 0.0% —
1015 VK055_3468 ATP-dependent DNA helicase RecG recG AlphaFold DB model + ColabFold model
5.6.2.4
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0003676Binding to a nucleic acid. GO:0006310Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Interchromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction. +58 total
No map 0.893 0.673 Hit 38.0% 4.92e-06
1016 VK055_3041 MATE efflux family protein AlphaFold DB model + ColabFold model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0042910Enables the directed movement of a xenobiotic from one side of a membrane to the other. A xenobiotic is a compound foreign to the organism exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. +25 total
No map 0.893 0.788 No Hit 0.0% —
1017 VK055_2073 ftsX-like permease family protein AlphaFold DB model + ColabFold model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
No map 0.893 0.984 No Hit 0.0% —
1018 VK055_4639 cysteine desulfurase IscS iscS AlphaFold DB model + ColabFold model
2.8.1.7
GO:0031071Catalysis of the reaction: L-cysteine + [enzyme]-cysteine = L-alanine + [enzyme]-S-sulfanylcysteine. GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0044571The incorporation of two iron atoms and two sulfur atoms into an iron-sulfur cluster. +47 total
Chokepoint 19 0.892 0.469 Hit 70.7% 1.30e-29
1019 VK055_3596 H+ symporter family protein AlphaFold DB model + ColabFold model –
GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. +14 total
No map 0.892 0.659 Hit 23.4% 5.68e-06
1020 VK055_3108 transporter, anaerobic C4-dicarboxylate uptake family protein AlphaFold DB model + ColabFold model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0015740The directed movement of a C4-dicarboxylate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A C4-dicarboxylate is the anion of a dicarboxylic acid that contains four carbon atoms. GO:0015556Enables the transfer of C4-dicarboxylate from one side of a membrane to the other. +14 total
No map 0.892 0.973 No Hit 0.0% —
1021 VK055_1831 PTS system, N-acetylglucosamine-specific IIBC component nagE AlphaFold DB model + ColabFold model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0015572Enables the transfer of N-acetylglucosamine from one side of a membrane to the other. The D isomer of N-acetylglucosamine is a common structural unit of glycoproteins in plants, bacteria and animals; it is often the terminal sugar of an oligosaccharide group of a glycoprotein. GO:0009401The uptake and phosphorylation of specific carbohydrates from the extracellular environment; uptake and phosphorylation are coupled, making the PTS a link between the uptake and metabolism of sugars; phosphoenolpyruvate is the original phosphate donor; phosphoenolpyruvate passes the phosphate via a signal transduction pathway, to enzyme 1 (E1), which in turn passes it on to the histidine protein, HPr; the next step in the system involves sugar-specific membrane-bound complex, enzyme 2 (EII), which transports the sugar into the cell; it includes the sugar permease, which catalyzes the transport reactions; EII is usually divided into three different domains, EIIA, EIIB, and EIIC. +69 total
No map 0.892 0.896 No Hit 0.0% —
1022 VK055_0317 doxX family protein ColabFold model – – No map 0.892 0.733 No Hit 0.0% —
1023 VK055_4626 SURF4 family protein AlphaFold DB model + ColabFold model –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
No map 0.891 0.948 No Hit 0.0% —
1024 VK055_3475 voltage gated chloride channel family protein AlphaFold DB model + ColabFold model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0006821The directed movement of chloride into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. GO:0005247Enables the transmembrane transfer of a chloride ion by a voltage-gated channel. A voltage-gated channel is a channel whose open state is dependent on the voltage across the membrane in which it is embedded. +36 total
No map 0.891 0.772 No Hit 0.0% —
1025 VK055_2852 beta-galactosidase trimerization domain protein AlphaFold DB model + ColabFold model
3.2.1.23
GO:0009341A protein complex that possesses beta-galactosidase activity, i.e. catalyzes the hydrolysis of terminal non-reducing beta-D-galactose residues in beta-D-galactosides. In E. coli, the complex is a homotetramer; dimeric and hexameric beta-galactosidase complexes have been observed in other species. GO:0005975The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. GO:0004565Catalysis of the hydrolysis of terminal, non-reducing beta-D-galactose residues in beta-D-galactosides. +14 total
No map 0.891 0.541 No Hit 0.0% —
Page of 204 · 5081 total proteins