Proteins

Genome: KpATCC43816

Description: Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome

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161 proteins Structure: Experimental

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Structure: Has experimental PDB ×
# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
101 VK055_4005 urease subunit gamma ureA Experimental + ColabFold
3.5.1.5
GO:0043419The chemical reactions and pathways resulting in the breakdown of urea, the water soluble compound O=C-(NH2)2. GO:0016151Binding to a nickel (Ni) cation. GO:0009039Catalysis of the reaction: urea + 2 H2O + H+ = hydrogencarbonate + 2 NH4+. +25 total
0.492 No Hit 0.0% —
102 VK055_1181 cysB cysB Experimental + ColabFold –
GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. +25 total
0.487 No Hit 0.0% —
103 VK055_2688 putative LACI-type transcriptional regulator Experimental + ColabFold – – 0.484 No Hit 0.0% —
104 VK055_4858 NUDIX domain protein Experimental + ColabFold
3.6.1.9 3.6.1.12 3.6.1.- +14 total
GO:0016818Catalysis of the hydrolysis of any acid anhydride which contains phosphorus. GO:0016787Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. GO:0047840Catalysis of the reaction: dCTP + H2O = dCMP + H+ + diphosphate. +25 total
0.472 No Hit 0.0% —
105 VK055_3979 1,3-propanediol oxidoreductase dhaT Experimental + ColabFold
1.1.1.202
GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. GO:0046872Binding to a metal ion. GO:0047516Catalysis of the reaction: propane-1,3-diol + NAD+ = 3-hydroxypropanal + NADH + H+. +14 total
0.464 Hit 27.3% 1.08e-36
106 VK055_3495 pantetheine-phosphate adenylyltransferase coaD Experimental + ColabFold
2.7.7.3
GO:0004595Catalysis of the reaction: ATP + pantetheine 4'-phosphate = 3'-dephospho-CoA + diphosphate. GO:0009058A cellular process consisting of the biochemical pathways by which a living organism synthesizes chemical substances. This typically represents the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. +36 total
0.457 No Hit 0.0% —
107 VK055_0406 diacetyl reductase (S-acetoin forming) budC Experimental + ColabFold
1.1.1.304
GO:0045150The chemical reactions and pathways resulting in the breakdown of acetoin, 3-hydroxy-2-butanone. GO:0019152Catalysis of the reaction: acetoin + NAD+ = diacetyl + NADH + H+. This reaction is catalyzed in the reverse direction. GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. +14 total
0.457 Hit 41.9% 7.64e-11
108 VK055_2800 ornithine carbamoyltransferase argF Experimental + ColabFold
2.1.3.3
GO:0016743Catalysis of the transfer of a carboxyl- or carbamoyl group from one compound (donor) to another (acceptor). GO:0006591The chemical reactions and pathways involving ornithine, an amino acid only rarely found in proteins, but which is important in living organisms as an intermediate in the reactions of the urea cycle and in arginine biosynthesis. GO:0016597Binding to an amino acid, organic acids containing one or more amino substituents. +58 total
0.453 Hit 36.9% 2.95e-56
109 VK055_3980 hypothetical protein Experimental + ColabFold – – 0.448 No Hit 0.0% —
110 VK055_1025 putative O-METHYLTRANSFERASE Experimental + ColabFold –
GO:0008171Catalysis of the transfer of a methyl group to the oxygen atom of an acceptor molecule.
0.44 Hit 36.5% 5.70e-11
111 VK055_4658 outer membrane assembly lipoprotein YfgL yfgL Experimental + ColabFold –
GO:0005515Binding to a protein. GO:0009279A lipid bilayer that forms the outermost membrane of the cell envelope; enriched in polysaccharide and protein; the outer leaflet of the membrane contains specific lipopolysaccharide structures. GO:0043165The assembly of an outer membrane of the type formed in Gram-negative bacteria. This membrane is enriched in polysaccharide and protein, and the outer leaflet of the membrane contains specific lipopolysaccharide structures. +14 total
0.438 No Hit 0.0% —
112 VK055_2955 putative chaperone DnaJ Experimental + ColabFold –
GO:0006457The process of assisting in the covalent and noncovalent assembly of single chain polypeptides or multisubunit complexes into the correct tertiary structure. GO:0051082Binding to an unfolded protein.
0.437 Hit 54.7% 7.74e-15
113 VK055_1987 oxygen-insensitive NAD(P)H nitroreductase nfnB Experimental + ColabFold –
GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.
0.435 No Hit 0.0% —
114 VK055_2879 esterase yjfP Experimental + ColabFold
3.1.1.23
GO:0008236Catalysis of the hydrolysis of peptide bonds in a polypeptide chain by a catalytic mechanism that involves a catalytic triad consisting of a serine nucleophile that is activated by a proton relay involving an acidic residue (e.g. aspartate or glutamate) and a basic residue (usually histidine). GO:0006508The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds. GO:0047372Catalysis of the reaction: a monoacylglycerol + H2O = a fatty acid + glycerol + H+.
0.433 No Hit 0.0% —
115 VK055_1374 3-oxoacyl-[acyl-carrier-protein] reductase fabG Experimental + ColabFold
1.1.1.100
GO:0006633The chemical reactions and pathways resulting in the formation of a fatty acid, any of the aliphatic monocarboxylic acids that can be liberated by hydrolysis from naturally occurring fats and oils. Fatty acids are predominantly straight-chain acids of 4 to 24 carbon atoms, which may be saturated or unsaturated; branched fatty acids and hydroxy fatty acids also occur, and very long chain acids of over 30 carbons are found in waxes. GO:0051287Binding to nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD+, or the reduced form, NADH. GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. +25 total
0.42 Hit 65.6% 2.44e-06
116 VK055_2468 8-oxo-dGTPase mutT Experimental + ColabFold
3.6.1.55
GO:0008413Catalysis of the reaction: 8-oxo-7,8-dihydroguanosine triphosphate (8-oxo-GTP) + H2O = 8-oxo-7,8-dihydroguanosine diphosphate (8-oxo-GDP) + phosphate. 8-oxo-7,8-dihydroguanosine triphosphate (8-oxo-GTP) is the oxidised form of the free guanine nucleotide and can act as a potent mutagenic substrate for transcription. GO:0006281The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. GO:0016787Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. +58 total
0.417 No Hit 0.0% —
117 VK055_3519 serine O-acetyltransferase cysE Experimental + ColabFold –
GO:0009001Catalysis of the reaction: L-serine + acetyl-CoA = O-acetyl-L-serine + CoA. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0006535OBSOLETE. The chemical reactions and pathways resulting in the formation of cysteine from L- serine. +14 total
0.415 No Hit 0.0% —
118 VK055_1539 3-deoxy-D-manno-octulosonate cytidylyltransferase kdsB Experimental + ColabFold
2.7.7.38
GO:0008690Catalysis of the reaction: CTP + 3-deoxy-D-manno-octulosonate = diphosphate + CMP-3-deoxy-D-manno-octulosonate. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. +25 total
0.415 No Hit 0.0% —
119 VK055_1479 fe(3+)-binding periplasmic protein fbpA Experimental + ColabFold –
GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. GO:0030288The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin peptidoglycan layer (PGL), also referred to as a thin cell wall. GO:0046872Binding to a metal ion. +14 total
0.406 No Hit 0.0% —
120 VK055_1825 fur fur Experimental + ColabFold –
GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. +47 total
0.396 No Hit 0.0% —
121 VK055_4006 urease accessory protein ureD ureD Experimental + ColabFold –
GO:0016151Binding to a nickel (Ni) cation. GO:0006807OBSOLETE. The chemical reactions and pathways involving organic or inorganic compounds that contain nitrogen. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
0.385 No Hit 0.0% —
122 VK055_1527 outer membrane protein C ompC3 Experimental + ColabFold –
GO:0015288Enables the transfer of substances, sized less than 1000 Da, from one side of a membrane to the other. The transmembrane portions of porins consist exclusively of beta-strands which form a beta-barrel. They are found in the outer membranes of Gram-negative bacteria, mitochondria, plastids and possibly acid-fast Gram-positive bacteria. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0009279A lipid bilayer that forms the outermost membrane of the cell envelope; enriched in polysaccharide and protein; the outer leaflet of the membrane contains specific lipopolysaccharide structures. +25 total
0.383 No Hit 0.0% —
123 VK055_0024 yedD-like family protein Experimental + ColabFold – – 0.382 No Hit 0.0% —
124 VK055_0969 indole-3-acetyl-aspartic acid hydrolase iaaH Experimental + ColabFold –
GO:0016810Catalysis of the hydrolysis of any carbon-nitrogen bond, C-N, with the exception of peptide bonds. GO:0016787Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc.
0.378 No Hit 0.0% —
125 VK055_2391 MTA/SAH nucleosidase mtnN Experimental + ColabFold –
GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0019509OBSOLETE. The generation of L-methionine (2-amino-4-(methylthio)butanoic acid) from methylthioadenosine. GO:0009164The chemical reactions and pathways resulting in the breakdown of any one of a family of organic molecules consisting of a purine or pyrimidine base covalently bonded to a sugar ribose (a ribonucleoside) or deoxyribose (a deoxyribonucleoside). +36 total
0.374 No Hit 0.0% —
Page of 7 · 161 total proteins