Proteins

Genome: KpATCC43816

Description: Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome

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# Protein Description Gene Structure EC GO Metabolism Druggability (P2Rank) P2RANK ligandability score for the best pocket in the experimental structure (0–1). Higher values indicate higher predicted ligandability. Available only for genomes analyzed with the curated pipeline. Druggability (FPocket) FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
1551 VK055_3020 tannase and feruloyl esterase family protein ColabFold model – – No map 0.800 0.85 No Hit 0.0% —
1552 VK055_2727 polysaccharide pyruvyl transferase family protein Experimental + ColabFold model – – No map 0.800 0.187 No Hit 0.0% —
1553 VK055_2655 2-oxo-hepta-3-ene-1,7-dioic acid hydratase hpaH AlphaFold DB model + ColabFold model –
GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0018817Catalysis of the reaction: cis-2-oxohept-3-ene-1,7-dioate + H2O = 2,4-dihydroxy-hept-trans-2-ene-1,7-dioate. GO:0019439OBSOLETE. The chemical reactions and pathways resulting in the breakdown of aromatic compounds, any substance containing an aromatic carbon ring. +25 total
Chokepoint 1 0.800 0.435 No Hit 0.0% —
1554 VK055_2448 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.800 0.746 No Hit 0.0% —
1555 VK055_1822 esterase ybfF ybfF AlphaFold DB model + ColabFold model –
GO:0016787Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc.
No map 0.800 0.315 Hit 45.1% 6.01e-15
1556 VK055_0353 NMT1-like family protein AlphaFold DB model + ColabFold model – – No map 0.800 0.341 No Hit 0.0% —
1557 VK055_0134 fumarylacetoacetate hydrolase domain-containing protein 1 fahHD1 AlphaFold DB model + ColabFold model –
GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0018773Catalysis of the reaction: acetylpyruvate + H2O = acetate + H+ + pyruvate. GO:0046872Binding to a metal ion.
Chokepoint 1 0.800 0.456 Hit 46.5% 1.95e-62
1558 VK055_2960 sugar (Glycoside-Pentoside-Hexuronide) transporter domain protein gph4 AlphaFold DB model + ColabFold model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0015293Enables the active transport of a solute across a membrane by a mechanism whereby two or more species are transported together in the same direction in a tightly coupled process not directly linked to a form of energy other than chemiosmotic energy. GO:0008643The directed movement of carbohydrate into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Carbohydrates are a group of organic compounds based of the general formula Cx(H2O)y. +25 total
No map 0.799 0.944 Hit 27.4% 1.04e-07
1559 VK055_1215 yniB-like family protein AlphaFold DB model + ColabFold model – – No map 0.799 0.913 No Hit 0.0% —
1560 VK055_5065 diguanylate cyclase domain protein AlphaFold DB model + ColabFold model – – Chokepoint 1 0.798 0.539 No Hit 0.0% —
1561 VK055_0342 2-keto-4-pentenoate hydratase mhpD AlphaFold DB model + ColabFold model
4.2.1.80
GO:0008684Catalysis of the reaction: 4-hydroxy-2-oxopentanoate = 2-oxopent-4-enoate + H2O. GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0030145Binding to a manganese ion (Mn). +36 total
Chokepoint 3 0.798 0.911 No Hit 0.0% —
1562 VK055_2591 purine nucleoside phosphorylase deoD AlphaFold DB model + ColabFold model
2.4.2.1
GO:0016763Catalysis of the transfer of a pentosyl group from one compound (donor) to another (acceptor). GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0009116The chemical reactions and pathways involving a nucleoside, a nucleobase linked to either beta-D-ribofuranose (a ribonucleoside) or 2-deoxy-beta-D-ribofuranose, (a deoxyribonucleoside), e.g. adenosine, guanosine, inosine, cytidine, uridine and deoxyadenosine, deoxyguanosine, deoxycytidine and thymidine (= deoxythymidine). +58 total
Chokepoint 8 0.797 0.684 No Hit 0.0% —
1563 VK055_2176 putative 2-dehydropantoate 2-reductase apbA AlphaFold DB model + ColabFold model
1.1.1.169
GO:0008677Catalysis of the reaction: (R)-pantoate + NADP+ = 2-dehydropantoate + H+ + NADPH. GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. GO:0015940The chemical reactions and pathways resulting in the formation of pantothenate, the anion of pantothenic acid. It is a B complex vitamin that is a constituent of coenzyme A and is distributed ubiquitously in foods. +25 total
Chokepoint 2 0.797 0.241 No Hit 0.0% —
1564 VK055_1709 heme ABC exporter, ATP-binding protein CcmA ccmA4 AlphaFold DB model + ColabFold model –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.
No map 0.797 0.13 Hit 36.9% 2.73e-32
1565 VK055_0680 dipeptidase AC. Metallo peptidase AlphaFold DB model + ColabFold model –
GO:0006508The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds. GO:0070573Catalysis of the hydrolysis of a dipeptide by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions.
No map 0.797 0.315 Hit 28.3% 9.92e-08
1566 VK055_4832 citrate transporter family protein AlphaFold DB model + ColabFold model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0006813The directed movement of potassium ions (K+) into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. GO:0008324Enables the transfer of cation from one side of a membrane to the other. +25 total
No map 0.796 0.453 Hit 38.8% 1.80e-06
1567 VK055_4827 phosphate acetyltransferase pta2 AlphaFold DB model + ColabFold model
2.3.1.8
GO:0008959Catalysis of the reaction: acetyl-CoA + phosphate = CoA + acetyl phosphate. GO:0016407Catalysis of the transfer of an acetyl group to an acceptor molecule. GO:0016746Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor). +25 total
Mapped 1 0.796 0.773 No Hit 0.0% —
1568 VK055_3636 yhhN-like family protein AlphaFold DB model + ColabFold model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0016787Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc.
No map 0.796 0.988 No Hit 0.0% —
1569 VK055_2873 L-xylulose 5-phosphate 3-epimerase AlphaFold DB model + ColabFold model –
GO:0005975The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. GO:0016861Catalysis of an oxidation-reduction (redox) reaction in which the hydrogen donor and acceptor, which is an aldose or a ketose, are the same molecule, and no oxidized product appears. GO:0034015Catalysis of the reaction: L-ribulose 5-phosphate = L-xylulose 5-phosphate. +14 total
Chokepoint 1 0.796 0.515 No Hit 0.0% —
1570 VK055_5119 thiazolinyl imide reductase family protein ybtU AlphaFold DB model + ColabFold model –
GO:0000166Binding to a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose.
No map 0.795 0.542 No Hit 0.0% —
1571 VK055_4768 nucleoside transporter, NupC family protein AlphaFold DB model + ColabFold model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:1901642The directed movement of nucleoside across a membrane. GO:0005337Enables the transfer of a nucleoside, a nucleobase linked to either beta-D-ribofuranose (ribonucleoside) or 2-deoxy-beta-D-ribofuranose, (a deoxyribonucleotide) from one side of a membrane to the other. +47 total
No map 0.795 0.975 Hit 26.5% 2.20e-28
1572 VK055_4463 PTS system, maltose and glucose-specific subfamily, IIC component domain protein AlphaFold DB model + ColabFold model –
GO:0009401The uptake and phosphorylation of specific carbohydrates from the extracellular environment; uptake and phosphorylation are coupled, making the PTS a link between the uptake and metabolism of sugars; phosphoenolpyruvate is the original phosphate donor; phosphoenolpyruvate passes the phosphate via a signal transduction pathway, to enzyme 1 (E1), which in turn passes it on to the histidine protein, HPr; the next step in the system involves sugar-specific membrane-bound complex, enzyme 2 (EII), which transports the sugar into the cell; it includes the sugar permease, which catalyzes the transport reactions; EII is usually divided into three different domains, EIIA, EIIB, and EIIC. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0008982Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + sugar(out) = protein histidine + sugar phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport. +47 total
No map 0.795 0.916 No Hit 0.0% —
1573 VK055_3629 hypothetical protein AlphaFold DB model + ColabFold model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.
No map 0.795 0.817 No Hit 0.0% —
1574 VK055_2052 adiC yjdE AlphaFold DB model + ColabFold model –
GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. +25 total
No map 0.795 0.649 Hit 26.4% 1.56e-06
1575 VK055_1061 putative C32 tRNA thiolase AlphaFold DB model + ColabFold model
2.8.1.-
GO:0008033The process in which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0051539Binding to a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands. +58 total
No map 0.795 0.687 Hit 30.6% 3.67e-10
Page of 204 · 5081 total proteins