Proteins

Genome: KpATCC43816

Description: Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome

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# Protein Description Gene Structure EC GO Metabolism Druggability (P2Rank) P2RANK ligandability score for the best pocket in the experimental structure (0–1). Higher values indicate higher predicted ligandability. Available only for genomes analyzed with the curated pipeline. Druggability (FPocket) FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
1876 VK055_4767 EAL domain protein AlphaFold DB model + ColabFold model –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0071111Catalysis of the reaction: cyclic di-3',5'-guanylate + H2O = 5'-phosphoguanylyl(3'->5')guanosine + H+.
No map 0.721 0.893 No Hit 0.0% —
1877 VK055_2421 2'-5' RNA ligase AlphaFold DB model + ColabFold model
3.1.4.58
GO:0008664Catalysis the reaction: a 3'-end 2',3'-cyclophospho-ribonucleotide-RNA + H2O = a 3'-end 2'-phospho-ribonucleotide-RNA + H+. GO:0004113Catalysis of the reaction: nucleoside 2',3'-cyclic phosphate + H2O = nucleoside 2'-phosphate. GO:0016874Catalysis of the joining of two molecules, or two groups within a single molecule, using the energy from the hydrolysis of ATP, a similar triphosphate, or a pH gradient.
No map 0.721 0.258 No Hit 0.0% —
1878 VK055_4212 bacterial regulatory helix-turn-helix, lysR family protein AlphaFold DB model + ColabFold model –
GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
No map 0.720 0.747 No Hit 0.0% —
1879 VK055_1681 citrate transporter family protein AlphaFold DB model + ColabFold model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.
No map 0.720 0.894 Hit 31.8% 8.37e-10
1880 VK055_3953 oxidoreductase, NAD-binding Rossmann fold family protein AlphaFold DB model + ColabFold model –
GO:0000166Binding to a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose.
No map 0.719 0.751 Hit 25.5% 1.78e-18
1881 VK055_1538 hypothetical protein AlphaFold DB model + ColabFold model –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0071555A process that results in the assembly, arrangement of constituent parts, or disassembly of the cell wall, the rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. GO:0043164A cellular process that results in the biosynthesis of constituent macromolecules, assembly, and arrangement of constituent parts of a cell wall of the type found in Gram-negative bacteria. The cell wall is the rigid or semi-rigid envelope lying outside the cell membrane. +14 total
No map 0.719 0.071 No Hit 0.0% —
1882 VK055_1500 SOS cell division inhibitor sulA AlphaFold DB model + ColabFold model –
GO:0051782Any process that stops, prevents, or reduces the frequency, rate or extent of cell division. GO:0009432An error-prone process for repairing damaged microbial DNA. GO:0000917The assembly and arrangement of a septum that spans the plasma membrane interface between progeny cells following cytokinesis. The progeny cells that form a division septum are not able to exchange intracellular material. +14 total
No map 0.718 0.566 No Hit 0.0% —
1883 VK055_1273 bacterial regulatory helix-turn-helix, lysR family protein AlphaFold DB model + ColabFold model –
GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
No map 0.718 0.802 No Hit 0.0% —
1884 VK055_0265 cardiolipin synthase cls AlphaFold DB model + ColabFold model
2.7.8.-
GO:0032049The chemical reactions and pathways resulting in the formation of cardiolipin, 1,3-bis(3-phosphatidyl)glycerol. GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0008808Catalysis of the reaction: phosphatidylglycerol + phosphatidylglycerol = diphosphatidylglycerol (cardiolipin) + glycerol. +25 total
Mapped 3 0.718 0.412 No Hit 0.0% —
1885 VK055_4858 NUDIX domain protein Experimental + ColabFold model
3.6.1.9 3.6.1.12 3.6.1.- +14 total
GO:0016818Catalysis of the hydrolysis of any acid anhydride which contains phosphorus. GO:0016787Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. GO:0047840Catalysis of the reaction: dCTP + H2O = dCMP + H+ + diphosphate. +25 total
No map 0.717 0.472 No Hit 0.0% —
1886 VK055_4083 tRNA (guanine-N(7)-)-methyltransferase trmB AlphaFold DB model + ColabFold model
2.1.1.33
GO:0006400The covalent alteration of one or more nucleotides within a tRNA molecule to produce a tRNA molecule with a sequence that differs from that coded genetically. GO:0008176Catalysis of the reaction: guanosine46 in tRNA + S-adenosyl-L-methionine = N7-methylguanosine46 in tRNA + S-adenosyl-L-homocysteine. GO:0043527A multimeric protein complex involved in the methylation of specific nucleotides in tRNA.
Mapped 1 0.717 0.757 Hit 27.1% 6.87e-06
1887 VK055_3719 hypothetical protein AlphaFold DB model + ColabFold model – – No map N/A 0.717 No Hit 0.0% —
1888 VK055_2326 ubiquinone oxidoreductase, Na(+)-translocating, B subunit nqrB AlphaFold DB model + ColabFold model
7.2.1.1
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0016655Catalysis of an oxidation-reduction (redox) reaction in which NADH or NADPH acts as a hydrogen or electron donor and reduces a quinone or a similar acceptor molecule. GO:0010181Binding to flavin mono nucleotide. Flavin mono nucleotide (FMN) is the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. +47 total
No map 0.717 0.939 No Hit 0.0% —
1889 VK055_1626 phage holin 2 family protein AlphaFold DB model + ColabFold model –
GO:0044660The dissemination of mature viral particles from a host cell via the formation by the virus of pores in its host cell membrane.
No map N/A 0.717 No Hit 0.0% —
1890 VK055_4692 dnaA regulatory inactivator Hda hda AlphaFold DB model + ColabFold model –
GO:0032297Any process that stops, prevents, or reduces the frequency, rate or extent of initiation of DNA-dependent DNA replication.
No map 0.716 0.487 No Hit 0.0% —
1891 VK055_4047 hypothetical protein AlphaFold DB model + ColabFold model – – No map N/A 0.716 No Hit 0.0% —
1892 VK055_2890 hypothetical protein AlphaFold DB model + ColabFold model – – No map N/A 0.716 No Hit 0.0% —
1893 VK055_2639 hypothetical protein AlphaFold DB model + ColabFold model –
GO:0016829Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring.
No map 0.716 0.577 No Hit 0.0% —
1894 VK055_0077 lipid A biosynthesis (KDO)2-(lauroyl)-lipid IVA acyltransferase msbB AlphaFold DB model + ColabFold model
2.3.1.243
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0016740Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2. GO:0009103The chemical reactions and pathways resulting in the formation of lipopolysaccharides, any of a group of related, structurally complex components of the outer membrane of Gram-negative bacteria. +47 total
Chokepoint 1 0.716 0.86 No Hit 0.0% —
1895 VK055_4729 putative carboxysome structural protein with predicted role in ethanolamine utilization AlphaFold DB model + ColabFold model –
GO:0031469An organelle found in bacteria consisting of a proteinaceous coat containing metabolic enzymes whose purpose is the sequestration or concentration of metabolites and which has the appearance of a polygonal granule by electron microscopy. GO:0005198The action of a molecule that contributes to the structural integrity of a complex.
No map 0.715 0.432 No Hit 0.0% —
1896 VK055_4682 cyclic di-GMP phosphodiesterase YfgF yfgF AlphaFold DB model + ColabFold model –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0071111Catalysis of the reaction: cyclic di-3',5'-guanylate + H2O = 5'-phosphoguanylyl(3'->5')guanosine + H+.
Chokepoint 1 0.715 0.544 No Hit 0.0% —
1897 VK055_3502 putative lipopolysaccharide biosynthesis proteinWalW AlphaFold DB model + ColabFold model –
GO:0005975The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y.
No map 0.715 0.556 No Hit 0.0% —
1898 VK055_1204 putative alcohol dehydrogenase zinc-binding domain protein ColabFold model –
GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.
No map 0.715 0.512 Hit 36.1% 9.70e-11
1899 VK055_1051 hypothetical protein AlphaFold DB model + ColabFold model –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
No map N/A 0.715 No Hit 0.0% —
1900 VK055_0686 L-2,4-diaminobutyrate decarboxylase ddc AlphaFold DB model + ColabFold model –
GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0019752The chemical reactions and pathways involving carboxylic acids, any organic acid containing one or more carboxyl (COOH) groups or anions (COO-). GO:0016830Catalysis of the cleavage of C-C bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. +36 total
Mapped 1 0.715 0.636 Hit 49.0% 1.62e-23
Page of 204 · 5081 total proteins