Proteins

Genome: KpATCC43816

Description: Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome

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5081 proteins

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# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
1926 VK055_4906 drug resistance transporter, Bcr/CflA subfamily protein AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:1990961A process that reduces or removes the toxicity of a xenobiotic by exporting it outside the cell. GO:0042910Enables the directed movement of a xenobiotic from one side of a membrane to the other. A xenobiotic is a compound foreign to the organism exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical. +58 total
0.673 No Hit 0.0% —
1927 VK055_4046 cystathionine beta-lyase metC2 Experimental + ColabFold
4.4.1.13
GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0019346The interconversion of homocysteine and cysteine via cystathionine. In contrast with enteric bacteria and mammals, Saccharomyces cerevisiae has two transsulfuration pathways employing two separate sets of enzymes. GO:0004121OBSOLETE. Catalysis of the reaction: cystathionine + H2O = L-homocysteine + NH3 + pyruvate. +69 total
0.673 Hit 31.9% 4.89e-47
1928 VK055_3688 phosphoribosyl transferase domain protein AlphaFold + ColabFold – – 0.673 No Hit 0.0% —
1929 VK055_3529 glutathione transferase-like protein possibly involved in selenium metabolism yibF AlphaFold + ColabFold –
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
0.673 Hit 30.3% 3.09e-08
1930 VK055_3468 ATP-dependent DNA helicase RecG recG AlphaFold + ColabFold
5.6.2.4
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0003676Binding to a nucleic acid. GO:0006310Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Interchromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction. +58 total
0.673 Hit 38.0% 4.92e-06
1931 VK055_0425 creatinine amidohydrolase family protein AlphaFold + ColabFold –
GO:0016811Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a linear amide. GO:0046872Binding to a metal ion. GO:0009231The chemical reactions and pathways resulting in the formation of riboflavin (vitamin B2), the precursor for the coenzymes flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD).
0.673 No Hit 0.0% —
1932 VK055_0282 integration host factor, alpha subunit ihfA AlphaFold + ColabFold –
GO:0030527The action of a molecule that contributes to the structural integrity of chromatin. GO:0006310Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Interchromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). +14 total
0.673 No Hit 0.0% —
1933 VK055_4777 hypothetical protein AlphaFold + ColabFold – – 0.672 No Hit 0.0% —
1934 VK055_4003 urease, alpha subunit ureC Experimental + ColabFold
3.5.1.5
GO:0016810Catalysis of the hydrolysis of any carbon-nitrogen bond, C-N, with the exception of peptide bonds. GO:0009039Catalysis of the reaction: urea + 2 H2O + H+ = hydrogencarbonate + 2 NH4+. GO:0016787Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. +47 total
0.672 No Hit 0.0% —
1935 VK055_3500 glycosyl transferases group 1 family protein AlphaFold + ColabFold –
GO:0016757Catalysis of the transfer of a glycosyl group from one compound (donor) to another (acceptor). GO:1901135The chemical reactions and pathways involving carbohydrate derivative.
0.672 No Hit 0.0% —
1936 VK055_1894 branched-chain amino acid transport system / permease component family protein AlphaFold + ColabFold –
GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. +14 total
0.672 No Hit 0.0% —
1937 VK055_2030 hypothetical protein AlphaFold + ColabFold – – 0.671 No Hit 0.0% —
1938 VK055_1829 putative b12-dependent methionine synthase AlphaFold + ColabFold – – 0.671 No Hit 0.0% —
1939 VK055_1760 hypothetical protein AlphaFold + ColabFold –
GO:0042910Enables the directed movement of a xenobiotic from one side of a membrane to the other. A xenobiotic is a compound foreign to the organism exposed to it. It may be synthesized by another organism (like ampicilin) or it can be a synthetic chemical. GO:1990961A process that reduces or removes the toxicity of a xenobiotic by exporting it outside the cell. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. +14 total
0.671 No Hit 0.0% —
1940 VK055_1515 nitrate transport protein ssuA AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0042626Primary active transporter of a solute across a membrane, via the reaction: ATP + H2O = ADP + phosphate, to directly drive the transport of a substance across a membrane. The transport protein may be transiently phosphorylated (P-type transporters), or not (ABC-type transporters and other families of transporters). Primary active transport occurs up the solute's concentration gradient and is driven by a primary energy source. GO:0042597The region between the inner (cytoplasmic) and outer membrane (Gram-negative Bacteria) or cytoplasmic membrane and cell wall (Fungi and Gram-positive Bacteria).
0.671 No Hit 0.0% —
1941 VK055_0949 SIS domain protein AlphaFold + ColabFold –
GO:0046348The chemical reactions and pathways resulting in the breakdown of any amino sugar, sugars containing an amino group in place of a hydroxyl group. GO:0097367Binding to a carbohydrate derivative. GO:1901135The chemical reactions and pathways involving carbohydrate derivative. +36 total
0.671 No Hit 0.0% —
1942 VK055_0693 oxidoreductase, Gfo/Idh/MocA family AlphaFold + ColabFold –
GO:0000166Binding to a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose.
0.671 Hit 26.4% 2.87e-07
1943 VK055_0199 type VI secretion system protein DUF879 impG2 AlphaFold + ColabFold – – 0.671 No Hit 0.0% —
1944 VK055_0139 hypothetical protein AlphaFold + ColabFold – – 0.671 No Hit 0.0% —
1945 VK055_4512 nrdI protein nrdI AlphaFold + ColabFold –
GO:0010181Binding to flavin mono nucleotide. Flavin mono nucleotide (FMN) is the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. GO:0036211The covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications). Includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification).
0.67 No Hit 0.0% —
1946 VK055_4214 YCII-related domain protein AlphaFold + ColabFold – – 0.67 No Hit 0.0% —
1947 VK055_3723 major Facilitator Superfamily protein ColabFold –
GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.
0.67 No Hit 0.0% —
1948 VK055_3159 phospholipase A pldA AlphaFold + ColabFold
3.1.1.32 3.1.1.4
GO:0004620Catalysis of the hydrolysis of a glycerophospholipid. GO:0006629The chemical reactions and pathways involving lipids, compounds soluble in an organic solvent but not, or sparingly, in an aqueous solvent. Includes fatty acids; neutral fats, other fatty-acid esters, and soaps; long-chain (fatty) alcohols and waxes; sphingoids and other long-chain bases; glycolipids, phospholipids and sphingolipids; and carotenes, polyprenols, sterols, terpenes and other isoprenoids. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. +58 total
0.67 No Hit 0.0% —
1949 VK055_2746 KAP family P-loop domain protein AlphaFold + ColabFold – – 0.67 No Hit 0.0% —
1950 VK055_2255 branched-chain amino-acid ABC transport system ATP-binding protein livF AlphaFold + ColabFold –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. GO:0015658Enables the transfer of branched-chain amino acids from one side of a membrane to the other. Branched-chain amino acids are amino acids with a branched carbon skeleton without rings. +14 total
0.67 Hit 29.4% 7.56e-08
Page of 204 · 5081 total proteins