Proteins

Genome: KpATCC43816

Description: Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome

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# Protein Description Gene Structure EC GO Metabolism Druggability (P2Rank) P2RANK ligandability score for the best pocket in the experimental structure (0–1). Higher values indicate higher predicted ligandability. Available only for genomes analyzed with the curated pipeline. Druggability (FPocket) FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
1826 VK055_3533 valine-pyruvate aminotransferase avtA AlphaFold DB model + ColabFold model –
GO:0009058A cellular process consisting of the biochemical pathways by which a living organism synthesizes chemical substances. This typically represents the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0030170Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. +36 total
Mapped 1 0.733 0.525 Hit 26.0% 1.46e-08
1827 VK055_1462 tartrate dehydrogenase AlphaFold DB model + ColabFold model
1.1.1.83
GO:0051287Binding to nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD+, or the reduced form, NADH. GO:0000287Binding to a magnesium (Mg) ion. GO:0016616Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP. +14 total
Mapped 2 0.733 0.378 Hit 41.2% 3.51e-09
1828 VK055_1318 isocitrate dehydrogenase, NADP-dependent icd AlphaFold DB model + ColabFold model
1.1.1.42
GO:0051287Binding to nicotinamide adenine dinucleotide, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NAD+, or the reduced form, NADH. GO:0016616Catalysis of an oxidation-reduction (redox) reaction in which a CH-OH group acts as a hydrogen or electron donor and reduces NAD+ or NADP. GO:0004450Catalysis of the reaction: isocitrate + NADP+ = 2-oxoglutarate + CO2 + NADPH. +36 total
Mapped 3 0.733 0.449 Hit 40.7% 4.43e-08
1829 VK055_0217 protein-(glutamine-N5) methyltransferase, release factor-specific prmC AlphaFold DB model + ColabFold model
2.1.1.297
GO:0006479The addition of a methyl group to a protein amino acid. A methyl group is derived from methane by the removal of a hydrogen atom. GO:0003676Binding to a nucleic acid. GO:0008276Catalysis of the transfer of a methyl group (CH3-) to a protein. +36 total
No map 0.733 0.929 Hit 29.9% 2.32e-17
1830 VK055_4774 glucokinase glk ColabFold model –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0051156The chemical reactions and pathways involving glucose 6-phosphate, a monophosphorylated derivative of glucose with the phosphate group attached to C-6. GO:0005536Binding to D-enantiomers of glucose. +25 total
Mapped 9 0.732 0.655 No Hit 0.0% —
1831 VK055_3511 glycosyl transferase 2 family protein AlphaFold DB model + ColabFold model –
GO:0016740Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2.
No map 0.732 0.468 No Hit 0.0% —
1832 VK055_3062 aspartate kinase, monofunctional class AlphaFold DB model + ColabFold model
2.7.2.4
GO:0008652The chemical reactions and pathways resulting in the formation of amino acids, organic acids containing one or more amino substituents. GO:0004072Catalysis of the reaction: L-aspartate + ATP = 4-phospho-L-aspartate + ADP + H+. GO:0009089OBSOLETE. The chemical reactions and pathways resulting in the formation of lysine, via the intermediate diaminopimelate. +47 total
Mapped 1 0.732 0.596 No Hit 0.0% —
1833 VK055_1264 putative enzyme related to aldose 1-epimerase AlphaFold DB model + ColabFold model
5.1.3.15
GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0030246Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates. GO:0005975The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. +36 total
No map 0.732 0.171 No Hit 0.0% —
1834 VK055_0013 outer membrane protein C ompC AlphaFold DB model + ColabFold model –
GO:0015288Enables the transfer of substances, sized less than 1000 Da, from one side of a membrane to the other. The transmembrane portions of porins consist exclusively of beta-strands which form a beta-barrel. They are found in the outer membranes of Gram-negative bacteria, mitochondria, plastids and possibly acid-fast Gram-positive bacteria. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0009279A lipid bilayer that forms the outermost membrane of the cell envelope; enriched in polysaccharide and protein; the outer leaflet of the membrane contains specific lipopolysaccharide structures. +25 total
No map 0.732 0.99 No Hit 0.0% —
1835 VK055_5025 undecaprenyl-phosphate glucose phosphotransferase wcaJ AlphaFold DB model + ColabFold model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0089702Catalysis of the reaction: di-trans,octa-cis-undecaprenyl phosphate + UDP-alpha-D-glucose = alpha-D-glucosyl di-trans,octa-cis-undecaprenyl diphosphate + UMP. GO:0009242The chemical reactions and pathways resulting in the formation of colanic acid, a capsular bacterial polysaccharide.
Mapped 1 0.731 0.898 No Hit 0.0% —
1836 VK055_4254 acetyl-CoA C-acetyltransferase family protein AlphaFold DB model + ColabFold model –
GO:0016747Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). GO:0016746Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor). GO:0003988Catalysis of the reaction: acyl-CoA + acetyl-CoA = CoA + 3-oxoacyl-CoA. +14 total
No map 0.731 0.952 Hit 49.3% 2.06e-12
1837 VK055_1813 hypothetical protein AlphaFold DB model + ColabFold model – – No map N/A 0.731 No Hit 0.0% —
1838 VK055_4584 hypothetical protein AlphaFold DB model + ColabFold model –
GO:0005507Binding to a copper (Cu) ion. GO:0016787Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. +14 total
No map 0.730 0.466 Hit 36.7% 2.15e-09
1839 VK055_4139 pepP pepP AlphaFold DB model + ColabFold model
3.4.11.9
GO:0030145Binding to a manganese ion (Mn). GO:0070006Catalysis of the hydrolysis of a single N-terminal amino acid residue from a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. +14 total
No map 0.730 0.191 Hit 39.3% 9.95e-24
1840 VK055_4094 putative transporter AlphaFold DB model + ColabFold model –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient.
No map 0.730 0.487 No Hit 0.0% —
1841 VK055_2742 PLD-like domain protein ColabFold model – – No map 0.730 0.604 No Hit 0.0% —
1842 VK055_2702 hypothetical protein Experimental + ColabFold model –
GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
No map N/A 0.73 No Hit 0.0% —
1843 VK055_4878 short chain fatty acid transporter family protein AlphaFold DB model + ColabFold model –
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
No map 0.729 0.687 No Hit 0.0% —
1844 VK055_3132 potassium uptake, TrkH family protein AlphaFold DB model + ColabFold model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0006812The directed movement of a monoatomic cation, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. Monatomic cations (also called simple cations) are positively charged ions consisting of exactly one atom. GO:0008324Enables the transfer of cation from one side of a membrane to the other. +58 total
No map 0.729 0.832 No Hit 0.0% —
1845 VK055_3351 permease family protein AlphaFold DB model + ColabFold model –
GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0015205Enables the transfer of a nucleobase, any nitrogenous base that is a constituent of a nucleoside, nucleotide, or nucleic acidfrom one side of a membrane to the other. +36 total
No map 0.728 0.887 No Hit 0.0% —
1846 VK055_1625 D-alanyl-D-alanine carboxypeptidase family protein AlphaFold DB model + ColabFold model –
GO:0008233Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid.
No map 0.728 0.155 No Hit 0.0% —
1847 VK055_0475 acid shock repeat family protein AlphaFold DB model + ColabFold model –
GO:0042597The region between the inner (cytoplasmic) and outer membrane (Gram-negative Bacteria) or cytoplasmic membrane and cell wall (Fungi and Gram-positive Bacteria).
No map N/A 0.728 No Hit 0.0% —
1848 VK055_3536 bacterial regulatory helix-turn-helix, AraC family protein AlphaFold DB model + ColabFold model –
GO:0043565Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. +14 total
No map 0.727 0.432 No Hit 0.0% —
1849 VK055_0069 DNA-binding regulatory, YebC/PmpR family protein AlphaFold DB model + ColabFold model –
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription.
No map 0.727 0.9 Hit 31.2% 2.73e-32
1850 VK055_1081 bacterial regulatory helix-turn-helix, lysR family protein AlphaFold DB model + ColabFold model –
GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0043565Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. +14 total
No map 0.726 0.713 No Hit 0.0% —
Page of 204 · 5081 total proteins