Proteins

Genome: KpATCC43816

Description: Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome

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5081 proteins

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# Protein Description Gene Structure EC GO Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
1826 VK055_3342 phosphate ABC transporter, phosphate-binding protein PstS pstS AlphaFold + ColabFold –
GO:0035435The process in which a phosphate is transported across a membrane. GO:0043190A complex for the transport of metabolites into and out of the cell, typically comprised of four domains; two membrane-associated domains and two ATP-binding domains at the intracellular face of the membrane, that form a central pore through the plasma membrane. Each of the four core domains may be encoded as a separate polypeptide or the domains can be fused in any one of a number of ways into multidomain polypeptides. In Bacteria and Archaebacteria, ABC transporters also include substrate binding proteins to bind substrate external to the cytoplasm and deliver it to the transporter. GO:0042301Binding to a phosphate ion.
0.693 No Hit 0.0% —
1827 VK055_0175 bacterial regulatory helix-turn-helix, lysR family protein AlphaFold + ColabFold –
GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. +14 total
0.693 No Hit 0.0% —
1828 VK055_4837 NADH:ubiquinone oxidoreductase, membrane subunitA nuoA AlphaFold + ColabFold
7.1.1.-
GO:0008137Catalysis of the reaction: NADH + ubiquinone + 5 H+(in) = NAD+ + ubiquinol + 4 H+(out). GO:0030964An integral membrane complex that possesses NADH oxidoreductase activity. The complex is one of the components of the electron transport chain. It catalyzes the transfer of a pair of electrons from NADH to a quinone. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. +14 total
0.692 Hit 48.6% 1.22e-06
1829 VK055_4377 queuine synthase queF AlphaFold + ColabFold
1.7.1.13
GO:0008616The chemical reactions and pathways resulting in the formation of queuosines, a series of nucleosides found in position 34 of tRNA and having an additional pentenyl ring added via an NH group to the methyl group of 7-methylguanosine. The pentenyl ring may carry other substituents. The wobble nucleoside of the tRNA sequence (position 34) corresponds to the first position of the anticodon. GO:0046857Catalysis of an oxidation-reduction (redox) reaction in which a nitrogenous group, excluding NH and NH2 groups, acts as a hydrogen or electron donor and reduces NAD or NADP. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. +14 total
0.692 No Hit 0.0% —
1830 VK055_3319 heme ABC exporter, ATP-binding protein CcmA ccmA11 AlphaFold + ColabFold –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. +14 total
0.692 Hit 36.3% 2.36e-06
1831 VK055_3240 hypothetical protein AlphaFold + ColabFold –
GO:0016788Catalysis of the hydrolysis of any ester bond. GO:0009166The chemical reactions and pathways resulting in the breakdown of nucleotides, any nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the glycose moiety; may be mono-, di- or triphosphate; this definition includes cyclic-nucleotides (nucleoside cyclic phosphates). GO:0046872Binding to a metal ion. +58 total
0.692 Hit 31.0% 9.00e-17
1832 VK055_1952 betaine aldehyde dehydrogenase betB Experimental + ColabFold
1.2.1.8
GO:0016620Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces NAD or NADP. GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. GO:0046872Binding to a metal ion. +25 total
0.692 Hit 53.1% 3.58e-08
1833 VK055_1185 hypothetical protein AlphaFold + ColabFold – – 0.692 No Hit 0.0% —
1834 VK055_3817 EAL domain protein AlphaFold + ColabFold – – 0.691 No Hit 0.0% —
1835 VK055_3390 hypothetical protein ColabFold – – 0.691 No Hit 0.0% —
1836 VK055_2289 gram-negative pili assembly chaperone, C-terminal domain protein ColabFold –
GO:0043711A process that is carried out at the cellular level which results in the assembly, arrangement of constituent parts, or disassembly of a pilus, a short filamentous structure on a bacterial cell, flagella-like in structure and generally present in many copies. GO:0030288The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin peptidoglycan layer (PGL), also referred to as a thin cell wall. GO:0071555A process that results in the assembly, arrangement of constituent parts, or disassembly of the cell wall, the rigid or semi-rigid envelope lying outside the cell membrane of plant, fungal and most prokaryotic cells, maintaining their shape and protecting them from osmotic lysis. +14 total
0.691 No Hit 0.0% —
1837 VK055_2224 shikimate kinase 2 aroL AlphaFold + ColabFold
2.7.1.71
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0000287Binding to a magnesium (Mg) ion. +47 total
0.691 Hit 25.1% 6.40e-08
1838 VK055_2217 exonuclease SbcCD, D subunit sbcD AlphaFold + ColabFold –
GO:0008408Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' end. GO:0004519Catalysis of the cleavage of ester linkages within nucleic acids by creating internal breaks. GO:0006259Any cellular metabolic process involving deoxyribonucleic acid. This is one of the two main types of nucleic acid, consisting of a long, unbranched macromolecule formed from one, or more commonly, two, strands of linked deoxyribonucleotides. +36 total
0.691 No Hit 0.0% —
1839 VK055_1977 hypothetical protein AlphaFold + ColabFold – – 0.691 No Hit 0.0% —
1840 VK055_1913 branched-chain amino acid transport system / permease component family protein AlphaFold + ColabFold –
GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. +14 total
0.691 No Hit 0.0% —
1841 VK055_0073 fecCD transport family protein AlphaFold + ColabFold –
GO:0043190A complex for the transport of metabolites into and out of the cell, typically comprised of four domains; two membrane-associated domains and two ATP-binding domains at the intracellular face of the membrane, that form a central pore through the plasma membrane. Each of the four core domains may be encoded as a separate polypeptide or the domains can be fused in any one of a number of ways into multidomain polypeptides. In Bacteria and Archaebacteria, ABC transporters also include substrate binding proteins to bind substrate external to the cytoplasm and deliver it to the transporter. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. +36 total
0.691 No Hit 0.0% —
1842 VK055_4925 apurinic endonuclease family protein AlphaFold + ColabFold
3.1.21.2
GO:0008270Binding to a zinc ion (Zn). GO:0006281The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). +47 total
0.69 No Hit 0.0% —
1843 VK055_2311 4-aminobutyrate transaminase gabT AlphaFold + ColabFold
2.6.1.48
GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0009448The chemical reactions and pathways involving gamma-aminobutyric acid (GABA, 4-aminobutyrate), an amino acid which acts as a neurotransmitter in some organisms. GO:0008483Catalysis of the transfer of an amino group to an acceptor, usually a 2-oxo acid. +912 total
0.69 Hit 34.7% 1.69e-19
1844 VK055_1944 L-fucose isomerase, C-terminal domain protein AlphaFold + ColabFold –
GO:0005996The chemical reactions and pathways involving monosaccharides, the simplest carbohydrates. They are polyhydric alcohols containing either an aldehyde or a keto group and between three to ten or more carbon atoms. They form the constitutional repeating units of oligo- and polysaccharides. GO:0008736Catalysis of the reaction: L-fucose = L-fuculose. GO:0016861Catalysis of an oxidation-reduction (redox) reaction in which the hydrogen donor and acceptor, which is an aldose or a ketose, are the same molecule, and no oxidized product appears. +25 total
0.69 No Hit 0.0% —
1845 VK055_0741 hypothetical protein AlphaFold + ColabFold – – 0.69 No Hit 0.0% —
1846 VK055_0394 heme exporter protein CcmB ccmB AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0015886The directed movement of heme, any compound of iron complexed in a porphyrin (tetrapyrrole) ring, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. GO:0017004The aggregation, arrangement and bonding together of a cytochrome complex. A cytochrome complex is a protein complex in which at least one of the proteins is a cytochrome, i.e. a heme-containing protein involved in catalysis of redox reactions. +36 total
0.69 No Hit 0.0% —
1847 VK055_3262 bacterial regulatory helix-turn-helix, AraC family protein AlphaFold + ColabFold –
GO:0043565Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. +36 total
0.689 No Hit 0.0% —
1848 VK055_1912 periplasmic binding and sugar binding domain of LacI family protein AlphaFold + ColabFold –
GO:0030288The region between the inner (cytoplasmic or plasma) membrane and outer membrane of organisms with two membranes such as Gram negative bacteria. These periplasmic spaces are relatively thick and contain a thin peptidoglycan layer (PGL), also referred to as a thin cell wall. GO:0030246Binding to a carbohydrate, which includes monosaccharides, oligosaccharides and polysaccharides as well as substances derived from monosaccharides by reduction of the carbonyl group (alditols), by oxidation of one or more hydroxy groups to afford the corresponding aldehydes, ketones, or carboxylic acids, or by replacement of one or more hydroxy group(s) by a hydrogen atom. Cyclitols are generally not regarded as carbohydrates. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.
0.689 No Hit 0.0% —
1849 VK055_1855 hemolysin secretion/activation ShlB/FhaC/HecB family protein AlphaFold + ColabFold –
GO:0015031The directed movement of proteins into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. GO:0098046A complex of proteins that permits the translocation of proteins across the outer membrane via a transmembrane pore, formed by a beta-barrel, into the extracellular milieu or directly into host cells; the secreted proteins contain all the information required for translocation of an effector molecule through the cell envelope. The type V secretion systems includes the autotransporters (type Va), the two-partner secretion system (type Vb) and the Oca family (type Vc). GO:0008320Enables the transfer of a protein from one side of a membrane to the other. +14 total
0.689 No Hit 0.0% —
1850 VK055_0632 ppa ppa AlphaFold + ColabFold
3.6.1.1
GO:0004427Catalysis of the reaction: diphosphate + H2O = H+ + 2 phosphate. GO:0006796The chemical reactions and pathways involving the phosphate group, the anion or salt of any phosphoric acid. GO:0000287Binding to a magnesium (Mg) ion. +14 total
0.689 Hit 34.3% 9.00e-10
Page of 204 · 5081 total proteins