Proteins

Genome: KpATCC43816

Description: Klebsiella pneumoniae subsp. pneumoniae strain ATCC 43816 KPPR1, complete genome

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# Protein Description Gene Structure EC GO Metabolism Druggability (P2Rank) P2RANK ligandability score for the best pocket in the experimental structure (0–1). Higher values indicate higher predicted ligandability. Available only for genomes analyzed with the curated pipeline. Druggability (FPocket) FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
1 VK055_4840 nuoE nuoE AlphaFold DB model + ColabFold model –
GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. GO:0051537Binding to a 2 iron, 2 sulfur (2Fe-2S) cluster; this cluster consists of two iron atoms, with two inorganic sulfur atoms found between the irons and acting as bridging ligands. GO:0046872Binding to a metal ion. +25 total
No map 0.000 0.506 Hit 35.0% 6.27e-27
2 VK055_0439 efflux transporter, RND family, MFP subunit AlphaFold DB model + ColabFold model –
GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. +25 total
No map 0.001 0.99 No Hit 0.0% —
3 VK055_1659 biofilm formation family protein AlphaFold DB model + ColabFold model – – No map 0.001 0.34 No Hit 0.0% —
4 VK055_1854 hypothetical protein ColabFold model – – No map 0.001 0.387 No Hit 0.0% —
5 VK055_2756 hypothetical protein ColabFold model – – No map 0.001 0.407 No Hit 0.0% —
6 VK055_4322 BMC domain protein AlphaFold DB model + ColabFold model –
GO:0031469An organelle found in bacteria consisting of a proteinaceous coat containing metabolic enzymes whose purpose is the sequestration or concentration of metabolites and which has the appearance of a polygonal granule by electron microscopy.
No map 0.001 0.532 No Hit 0.0% —
7 VK055_0840 putative prolyl endopeptidase AlphaFold DB model + ColabFold model – – No map 0.002 0.564 No Hit 0.0% —
8 VK055_0933 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.002 No pocket No Hit 0.0% —
9 VK055_1390 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.002 0.585 No Hit 0.0% —
10 VK055_1545 integration host factor, beta subunit ihfB AlphaFold DB model + ColabFold model –
GO:0006310Any process in which a new genotype is formed by reassortment of genes resulting in gene combinations different from those that were present in the parents. In eukaryotes genetic recombination can occur by chromosome assortment, intrachromosomal recombination, or nonreciprocal interchromosomal recombination. Interchromosomal recombination occurs by crossing over. In bacteria it may occur by genetic transformation, conjugation, transduction, or F-duction. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0030527The action of a molecule that contributes to the structural integrity of chromatin. +47 total
No map 0.002 0.367 No Hit 0.0% —
11 VK055_1688 stationary phase nucleoid protein that sequesters iron and protects DNA from damage dps AlphaFold DB model + ColabFold model
1.16.-.-
GO:0016722Catalysis of an oxidation-reduction in which the oxidation state of metal ion is altered. GO:0008199Binding to a ferric iron ion, Fe(III). GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. +47 total
No map 0.002 0.725 No Hit 0.0% —
12 VK055_1975 hypothetical protein ColabFold model – – No map 0.002 0.542 No Hit 0.0% —
13 VK055_2096 DNA-binding protein, YbaB/EbfC family AlphaFold DB model + ColabFold model –
GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0043590The region of a bacterial cell to which the DNA is confined. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
No map 0.002 0.328 No Hit 0.0% —
14 VK055_2105 acrA Membrane Fusion Protein acrA AlphaFold DB model + ColabFold model –
GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. +47 total
No map 0.002 0.448 No Hit 0.0% —
15 VK055_2361 putative-tRNA hydrolase domain protein AlphaFold DB model + ColabFold model
3.1.1.29
GO:0006415The process resulting in the release of a polypeptide chain from the ribosome, usually in response to a termination codon (UAA, UAG, or UGA in the universal genetic code). GO:0003747Involved in catalyzing the release of a nascent polypeptide chain from a ribosome. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. +47 total
No map 0.002 0.212 No Hit 0.0% —
16 VK055_2932 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.002 0.694 No Hit 0.0% —
17 VK055_2934 fxsA cytoplasmic membrane family protein AlphaFold DB model + ColabFold model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
No map 0.002 0.945 No Hit 0.0% —
18 VK055_3027 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.002 0.128 No Hit 0.0% —
19 VK055_4484 competence/damage-inducible CinA C-terminal domain protein AlphaFold DB model + ColabFold model – – No map 0.002 0.482 No Hit 0.0% —
20 VK055_0848 4-oxalocrotonate tautomerase family enzyme domain protein AlphaFold DB model + ColabFold model – – No map 0.003 0.155 No Hit 0.0% —
21 VK055_2135 DNA base-flipping protein ybaZ ColabFold model –
GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0006281The process of restoring DNA after damage. Genomes are subject to damage by chemical and physical agents in the environment (e.g. UV and ionizing radiations, chemical mutagens, fungal and bacterial toxins, etc.) and by free radicals or alkylating agents endogenously generated in metabolism. DNA is also damaged because of errors during its replication. A variety of different DNA repair pathways have been reported that include direct reversal, base excision repair, nucleotide excision repair, photoreactivation, bypass, double-strand break repair pathway, and mismatch repair pathway.
No map 0.003 0.683 Hit 44.7% 7.97e-06
22 VK055_2489 acetolactate synthase, small subunit ilvN AlphaFold DB model + ColabFold model
2.2.1.6
GO:1990610Binds to and modulates the activity of acetolactate synthase. GO:0009082The chemical reactions and pathways resulting in the formation of amino acids containing a branched carbon skeleton, comprising isoleucine, leucine and valine. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. +36 total
Chokepoint 2 0.003 0.712 No Hit 0.0% —
23 VK055_2929 hypothetical protein ColabFold model – – No map 0.003 0.799 No Hit 0.0% —
24 VK055_4198 acid stress chaperone hdeB AlphaFold DB model + ColabFold model –
GO:0009268Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a pH stimulus. pH is a measure of the acidity or basicity of an aqueous solution. GO:0051082Binding to an unfolded protein. GO:0042597The region between the inner (cytoplasmic) and outer membrane (Gram-negative Bacteria) or cytoplasmic membrane and cell wall (Fungi and Gram-positive Bacteria). +14 total
No map 0.003 0.481 No Hit 0.0% —
25 VK055_4349 cysteine desulfurase, sulfur acceptor subunit CsdE csdE AlphaFold DB model + ColabFold model – – Chokepoint 19 0.003 0.598 No Hit 0.0% —
Page of 204 · 5081 total proteins