Proteins

Genome: KpKP13

Description: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence

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Applied filters EC Number: 4.2.1.3

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EC Number: 4.2.1.3 ×
# Protein Description Gene Structure EC GO Metabolism Druggability (P2Rank) P2RANK ligandability score for the best pocket in the experimental structure (0–1). Higher values indicate higher predicted ligandability. Available only for genomes analyzed with the curated pipeline. Druggability (FPocket) FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
1 KP13_02836 glycerol dehydratase reactivase Experimental + ColabFold model
4.2.1.30
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0046405Catalysis of the reaction: glycerol = 3-hydroxypropanal + H2O. GO:0046872Binding to a metal ion.
No map 0.967 0.938 No Hit 0.0% —
2 KP13_01873 Aconitate hydratase acnB AlphaFold DB model + ColabFold model
4.2.1.3 4.2.1.99
GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0006099A nearly universal metabolic pathway in which the acetyl group of acetyl coenzyme A is effectively oxidized to two CO2 and four pairs of electrons are transferred to coenzymes. The acetyl group combines with oxaloacetate to form citrate, which undergoes successive transformations to isocitrate, 2-oxoglutarate, succinyl-CoA, succinate, fumarate, malate, and oxaloacetate again, thus completing the cycle. In eukaryotes the tricarboxylic acid is confined to the mitochondria. See also glyoxylate cycle. GO:0051539Binding to a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands. +58 total
No map 0.873 0.217 No Hit 0.0% —
3 KP13_02839 glycerol dehydratase large subunit dhaB Experimental + ColabFold model
4.2.1.30
GO:0016836Catalysis of the cleavage of a carbon-oxygen bond by elimination of water. GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0031419Binding to cobalamin (vitamin B12), a water-soluble vitamin characterized by possession of a corrin nucleus containing a cobalt atom. +14 total
No map 0.722 0.699 No Hit 0.0% —
4 KP13_02985 L(+)-tartrate dehydratase subunit alpha ttdA AlphaFold DB model + ColabFold model
4.2.1.32
GO:0016829Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring. GO:0051539Binding to a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands. GO:0008730Catalysis of the reaction: L-tartrate = H2O + oxaloacetate. +14 total
No map 0.643 0.404 No Hit 0.0% —
5 KP13_01923 3-isopropylmalate dehydratase large subunit leuC AlphaFold DB model + ColabFold model
4.2.1.33
GO:0003861Catalysis of the reaction: (2R,3S)-3-isopropylmalate = (2S)-2-isopropylmalate. GO:0051539Binding to a 4 iron, 4 sulfur (4Fe-4S) cluster; this cluster consists of four iron atoms, with the inorganic sulfur atoms found between the irons and acting as bridging ligands. GO:0009098The chemical reactions and pathways resulting in the formation of L-leucine, 2-amino-4-methylpentanoic acid. +25 total
No map 0.506 0.113 Hit 26.8% 2.05e-23
6 KP13_02838 glycerol dehydratase medium subunit dhaC Experimental + ColabFold model
4.2.1.30 4.2.1.28
GO:0046405Catalysis of the reaction: glycerol = 3-hydroxypropanal + H2O. GO:0050215Catalysis of the reaction: propane-1,2-diol = H2O + propanal.
No map 0.231 0.803 No Hit 0.0% —
7 KP13_02837 glycerol dehydratase small subunit dhaE Experimental + ColabFold model
4.2.1.30 4.2.1.28
GO:0046405Catalysis of the reaction: glycerol = 3-hydroxypropanal + H2O. GO:0050215Catalysis of the reaction: propane-1,2-diol = H2O + propanal.
No map 0.092 0.695 No Hit 0.0% —
8 KP13_01924 3-isopropylmalate dehydratase small subunit leuD AlphaFold DB model + ColabFold model
4.2.1.33
GO:0003861Catalysis of the reaction: (2R,3S)-3-isopropylmalate = (2S)-2-isopropylmalate. GO:0009316A heterodimeric enzyme complex composed of subunits leuC and leuD. Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate. GO:0009098The chemical reactions and pathways resulting in the formation of L-leucine, 2-amino-4-methylpentanoic acid. +14 total
No map 0.030 0.335 No Hit 0.0% —
9 KP13_02986 L(+)-tartrate dehydratase subunit beta ttdB AlphaFold DB model + ColabFold model
4.2.1.32
GO:0016836Catalysis of the cleavage of a carbon-oxygen bond by elimination of water. GO:0008730Catalysis of the reaction: L-tartrate = H2O + oxaloacetate.
No map 0.005 0.621 No Hit 0.0% —
Page 1 of 1 · 9 total proteins