Proteins

Genome: KpKP13

Description: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence

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5842 / 5842 proteins

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# Protein Description Gene Structure EC GO Metabolism Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
2801 KP13_02267 Diaminopimelate decarboxylase lysA AlphaFold DB model + ColabFold model
4.1.1.20
GO:0009089OBSOLETE. The chemical reactions and pathways resulting in the formation of lysine, via the intermediate diaminopimelate. GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0008836Catalysis of the reaction: meso-2,6-diaminopimelate + H+ = L-lysine + CO2. +14 total
No map 0.265 No Hit 0.0% —
2802 KP13_02270 Lichenan permease IIC component licC AlphaFold DB model + ColabFold model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0009401The uptake and phosphorylation of specific carbohydrates from the extracellular environment; uptake and phosphorylation are coupled, making the PTS a link between the uptake and metabolism of sugars; phosphoenolpyruvate is the original phosphate donor; phosphoenolpyruvate passes the phosphate via a signal transduction pathway, to enzyme 1 (E1), which in turn passes it on to the histidine protein, HPr; the next step in the system involves sugar-specific membrane-bound complex, enzyme 2 (EII), which transports the sugar into the cell; it includes the sugar permease, which catalyzes the transport reactions; EII is usually divided into three different domains, EIIA, EIIB, and EIIC. GO:0008982Catalysis of the PEP-dependent, phosphoryl transfer-driven transport of substances across a membrane. The transport happens by catalysis of the reaction: protein N-phosphohistidine + sugar(out) = protein histidine + sugar phosphate(in). This differs from primary and secondary active transport in that the solute is modified during transport. +14 total
No map 0.948 No Hit 0.0% —
2803 KP13_02272 Uxu operon regulator uxuR AlphaFold DB model + ColabFold model –
GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
No map 0.187 No Hit 0.0% —
2804 KP13_02273 HTH-type transcriptional regulator galR galR AlphaFold DB model + ColabFold model –
GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. +25 total
No map 0.379 No Hit 0.0% —
2805 KP13_02274 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.883 No Hit 0.0% —
2806 KP13_02278 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.557 No Hit 0.0% —
2807 KP13_02280 putative inner membrane protein AlphaFold DB model + ColabFold model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
No map 0.89 No Hit 0.0% —
2808 KP13_02281 DNA mismatch repair protein mutH mutH AlphaFold DB model + ColabFold model –
GO:0006304The covalent alteration of one or more nucleotide sites in DNA, resulting in a change in its properties. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid). GO:0004519Catalysis of the cleavage of ester linkages within nucleic acids by creating internal breaks. +36 total
No map 0.313 No Hit 0.0% —
2809 KP13_02282 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.212 No Hit 0.0% —
2810 KP13_02283 RNA pyrophosphohydrolase rppH AlphaFold DB model + ColabFold model
3.6.1.-
GO:0016787Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0034353Catalysis of the removal of a 5' terminal diphosphate from the 5'-triphosphate end of an mRNA, leaving a 5'-monophosphate end. +14 total
No map 0.19 No Hit 0.0% —
2811 KP13_02285 Prolipoprotein diacylglyceryl transferase lgt AlphaFold DB model + ColabFold model
2.5.1.145
GO:0005886The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins. GO:0042158The chemical reactions and pathways resulting in the formation of any conjugated, water-soluble protein in which the covalently attached nonprotein group consists of a lipid or lipids. GO:0008961Catalysis of the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the prospective N-terminal cysteine residue in an unmodified prolipoprotein.
No map 0.912 No Hit 0.0% —
2812 KP13_02287 hypothetical protein AlphaFold DB model + ColabFold model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
No map 0.629 No Hit 0.0% —
2813 KP13_02289 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.623 No Hit 0.0% —
2814 KP13_02290 hypothetical protein AlphaFold DB model + ColabFold model –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
No map 0.166 No Hit 0.0% —
2815 KP13_02291 Exodeoxyribonuclease V gamma chain recC AlphaFold DB model + ColabFold model –
GO:0009338An enzyme complex that catalyzes exonucleolytic cleavage (in the presence of ATP) in either 5' to 3' or 3' to 5' direction to yield 5'-phosphooligonucleotides. Exodeoxyribonuclease V shows a preference for double-stranded DNA and possesses DNA-dependent ATPase activity. It acts endonucleolytically on single-stranded circular DNA. GO:0008854Catalysis of the exonucleolytic cleavage (in the presence of ATP) in either 5' to 3' or 3' to 5' direction to yield 5'-phosphooligonucleotides. GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. +36 total
No map 0.581 No Hit 0.0% —
2816 KP13_02293 Exodeoxyribonuclease V beta chain recB AlphaFold DB model + ColabFold model
3.1.11.5 5.6.2.4
GO:0016787Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. GO:0003678Unwinding of a DNA helix, driven by ATP hydrolysis. GO:0008854Catalysis of the exonucleolytic cleavage (in the presence of ATP) in either 5' to 3' or 3' to 5' direction to yield 5'-phosphooligonucleotides. +912 total
No map 0.499 No Hit 0.0% —
2817 KP13_02294 Exodeoxyribonuclease V alpha chain recD AlphaFold DB model + ColabFold model
5.6.2.3
GO:0004386Catalysis of the reaction: ATP + H2O = ADP + phosphate, to drive the unwinding of a DNA or RNA helix. GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. GO:0006302The repair of double-strand breaks in DNA via homologous and nonhomologous mechanisms to reform a continuous DNA helix. +811 total
No map 0.712 No Hit 0.0% —
2818 KP13_02295 hypothetical protein AlphaFold DB model + ColabFold model – – No map 0.768 No Hit 0.0% —
2819 KP13_02296 Amino-acid acetyltransferase argA AlphaFold DB model + ColabFold model
2.3.1.1
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0016747Catalysis of the transfer of an acyl group, other than amino-acyl, from one compound (donor) to another (acceptor). GO:0006526The chemical reactions and pathways resulting in the formation of arginine, 2-amino-5-(carbamimidamido)pentanoic acid. +25 total
No map 0.919 No Hit 0.0% —
2820 KP13_02298 Threonine-phosphate decarboxylase cobD AlphaFold DB model + ColabFold model
4.1.1.81
GO:0030170Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. GO:0009058A cellular process consisting of the biochemical pathways by which a living organism synthesizes chemical substances. This typically represents the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones. GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. +25 total
No map 0.535 No Hit 0.0% —
2821 KP13_02299 putative propanediol utilization protein AlphaFold DB model + ColabFold model
2.7.1.177
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0016301Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. +14 total
No map 0.662 No Hit 0.0% —
2822 KP13_02300 putative propionate kinase pduW Experimental + ColabFold model –
GO:0016774Catalysis of the transfer of a phosphorus-containing group from one compound (donor) to a carboxyl group (acceptor). GO:0016310The process of introducing a phosphate group into a molecule, usually with the formation of a phosphoric ester, a phosphoric anhydride or a phosphoric amide. GO:0016301Catalysis of the transfer of a phosphate group, usually from ATP, to a substrate molecule. +47 total
No map 0.855 No Hit 0.0% —
2823 KP13_02301 Propanediol utilization protein pduV pduV AlphaFold DB model + ColabFold model –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0006576The chemical reactions and pathways occurring at the level of individual cells involving any of a group of naturally occurring, biologically active amines, such as norepinephrine, histamine, and serotonin, many of which act as neurotransmitters.
No map 0.636 No Hit 0.0% —
2824 KP13_02302 Propanediol utilization protein pduU pduU AlphaFold DB model + ColabFold model –
GO:0031469An organelle found in bacteria consisting of a proteinaceous coat containing metabolic enzymes whose purpose is the sequestration or concentration of metabolites and which has the appearance of a polygonal granule by electron microscopy.
No map 0.005 No Hit 0.0% —
2825 KP13_02303 putative propanediol utilization proteni AlphaFold DB model + ColabFold model –
GO:0031469An organelle found in bacteria consisting of a proteinaceous coat containing metabolic enzymes whose purpose is the sequestration or concentration of metabolites and which has the appearance of a polygonal granule by electron microscopy.
No map 0.076 No Hit 0.0% —
Page of 234 · 5842 total proteins