Proteins

Genome: KpKP13

Description: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence

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5192 / 5842 proteins Structure: AlphaFold

Scoring formula None

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Structure: AlphaFold ×
# Protein Description Gene Structure EC GO Metabolism Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
3076 KP13_00096 putative 2-aminoethylphosphonate import ATP-binding protein phnT phnT AlphaFold + ColabFold –
GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. +36 total
No map 0.476 Hit 43.3% 2.59e-07
3077 KP13_01389 Beta-lactamase OXA-9 bla AlphaFold + ColabFold
3.5.2.6
GO:0008800Catalysis of the reaction: a beta-lactam + H2O = a substituted beta-amino acid. GO:0017001The chemical reactions and pathways resulting in the breakdown of antibiotic, a substance produced by or derived from certain fungi, bacteria, and other organisms, that can destroy or inhibit the growth of other microorganisms. GO:0008658Binding to penicillin, an antibiotic that contains the condensed beta-lactamthiazolidine ring system. +14 total
No map 0.475 No Hit 0.0% —
3078 KP13_00215 putative tRNA/rRNA methyltransferase AlphaFold + ColabFold
2.1.1.207
GO:0001510Posttranscriptional addition of a methyl group to either a nucleotide or 2'-O ribose in a polyribonucleotide. Usually uses S-adenosylmethionine as a cofactor. GO:0008173Catalysis of the transfer of a methyl group from a donor to a nucleoside residue in an RNA molecule. GO:0008168Catalysis of the transfer of a methyl group to an acceptor molecule. +811 total
No map 0.475 No Hit 0.0% —
3079 KP13_31631 Aminoacyl-histidine dipeptidase pepD AlphaFold + ColabFold
3.4.13.18
GO:0006508The hydrolysis of proteins into smaller polypeptides and/or amino acids by cleavage of their peptide bonds. GO:0016787Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. +25 total
No map 0.474 No Hit 0.0% —
3080 KP13_04147 Tellurium resistance protein terC AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
No map 0.474 No Hit 0.0% —
3081 KP13_03321 PhoH-like protein AlphaFold + ColabFold –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes.
No map 0.474 No Hit 0.0% —
3082 KP13_02132 Phosphonates import ATP-binding protein PhnC phnC AlphaFold + ColabFold –
GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. GO:0015416Enables the transfer of a solute or solutes from one side of a membrane to the other according to the reaction: ATP + H2O + phosphonate(out) = ADP + phosphate + phosphonate(in). A phosphonate is any salt, anion, or ester of phosphonic acid (HPO(OH)2). GO:0015716The directed movement of phosphonates into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. A phosphonate is any salt, anion, or ester of phosphonic acid (HPO(OH)2). +36 total
No map 0.474 Hit 32.1% 2.56e-16
3083 KP13_01140 hypothetical protein AlphaFold + ColabFold – – No map 0.474 No Hit 0.0% —
3084 KP13_00110 putative GlcNAc-PI de-N-acetylase AlphaFold + ColabFold –
GO:0016811Catalysis of the hydrolysis of any non-peptide carbon-nitrogen bond in a linear amide.
No map 0.474 No Hit 0.0% —
3085 KP13_03823 Glycine cleavage system transcriptional repressor gcvR AlphaFold + ColabFold –
GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
No map 0.473 No Hit 0.0% —
3086 KP13_03578 Outer membrane usher protein AlphaFold + ColabFold –
GO:0005515Binding to a protein. GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0015473A porin that acts in the assembly of fimbria together with fimbrial chaperone. +25 total
No map 0.473 No Hit 0.0% —
3087 KP13_02880 Inner membrane protein AlphaFold + ColabFold – – No map 0.473 No Hit 0.0% —
3088 KP13_00423 LysR family transcriptional regulator AlphaFold + ColabFold –
GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. +14 total
No map 0.473 No Hit 0.0% —
3089 KP13_05609 putative HTH-type transcriptional regulator AlphaFold + ColabFold –
GO:0043565Binding to DNA of a specific nucleotide composition, e.g. GC-rich DNA binding, or with a specific sequence motif or type of DNA e.g. promotor binding or rDNA binding. GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons.
No map 0.472 No Hit 0.0% —
3090 KP13_05341 HTH-type transcriptional regulator cysB cysB AlphaFold + ColabFold –
GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0000976Binding to a specific sequence of DNA that is part of a regulatory region that controls transcription of that section of the DNA. The transcribed region might be described as a gene, cistron, or operon. +14 total
No map 0.472 No Hit 0.0% —
3091 KP13_03587 Bifunctional protein folD folD AlphaFold + ColabFold –
GO:0004488Catalysis of the reaction: 5,10-methylenetetrahydrofolate + NADP+ = 5,10-methenyltetrahydrofolate + NADPH. GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. +58 total
No map 0.472 Hit 59.0% 7.62e-09
3092 KP13_03231 putative sigma(54) modulation protein AlphaFold + ColabFold –
GO:0044238The chemical reactions and pathways involving those compounds which are formed as a part of the normal anabolic and catabolic processes. These processes take place in most, if not all, cells of the organism. GO:0022627The small subunit of a ribosome located in the cytosol. GO:0043024Binding to a small ribosomal subunit. +14 total
No map 0.472 No Hit 0.0% —
3093 KP13_03039 Molybdenum cofactor biosynthesis protein C moaC AlphaFold + ColabFold
4.6.1.17
GO:0006777The chemical reactions and pathways resulting in the formation of the Mo-molybdopterin cofactor, essential for the catalytic activity of some enzymes. The cofactor consists of a mononuclear molybdenum (Mo) ion coordinated by one or two molybdopterin ligands. GO:0061799Catalysis of the reaction: (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate = cyclic pyranopterin phosphate + diphosphate.
No map 0.472 Hit 48.4% 3.48e-42
3094 KP13_02555 Fructokinase AlphaFold + ColabFold –
GO:0004396Catalysis of the reaction: ATP + D-hexose = ADP + D-hexose 6-phosphate.
No map 0.472 Hit 26.4% 1.19e-16
3095 KP13_01147 NADP-dependent L-serine/L-allo-threonine dehydrogenase AlphaFold + ColabFold
1.1.1.298 1.1.1.381
GO:0016491Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. GO:0035527Catalysis of the reaction: 3-hydroxypropanoate + NADP+ = 3-oxopropanoate + H+ + NADPH.
No map 0.472 Hit 40.0% 1.65e-08
3096 KP13_01055 hypothetical protein AlphaFold + ColabFold – – No map 0.472 No Hit 0.0% —
3097 KP13_00904 hypothetical protein AlphaFold + ColabFold – – No map 0.472 No Hit 0.0% —
3098 KP13_00339 hypothetical protein AlphaFold + ColabFold – – No map 0.472 No Hit 0.0% —
3099 KP13_00507 Elongation factor P efp AlphaFold + ColabFold –
GO:0005737The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures. GO:0003746Functions in chain elongation during polypeptide synthesis at the ribosome. GO:0043043The chemical reactions and pathways resulting in the formation of peptides, compounds of 2 or more (but usually less than 100) amino acids where the alpha carboxyl group of one is bound to the alpha amino group of another. This may include the translation of a precursor protein and its subsequent processing into a functional peptide. +25 total
No map 0.471 No Hit 0.0% —
3100 KP13_01511 hypothetical protein AlphaFold + ColabFold – – No map 0.47 No Hit 0.0% —
Page of 208 · 5192 total proteins