Proteins

Genome: KpKP13

Description: Klebsiella pneumoniae subsp. pneumoniae Kp13, complete sequence

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5192 / 5842 proteins Structure: AlphaFold

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Structure: AlphaFold ×
# Protein Description Gene Structure EC GO Metabolism Druggability FPocket druggability score for the preferred structure (0–1): experimental structure when available, otherwise predicted model. ≥ 0.7 highly druggable · ≥ 0.4 moderately druggable · < 0.4 low druggability. Human off-target BLASTP against the human proteome. Hit means at least one human match was detected at e-value <= 1e-5. Prefer No hit for pathogen-selective targets. Human identity (%) Best human BLAST identity percentage. Human E-value Best human BLAST E-value.
3401 KP13_03156 putative ABC transporter AlphaFold + ColabFold –
GO:0005524Binding to ATP, adenosine 5'-triphosphate, a universally important coenzyme and enzyme regulator. GO:0016887Catalysis of the reaction: ATP + H2O = ADP + H+ phosphate. ATP hydrolysis is used in some reactions as an energy source, for example to catalyze a reaction or drive transport against a concentration gradient. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other.
No map 0.418 Hit 64.7% 7.96e-08
3402 KP13_03047 hypothetical protein AlphaFold + ColabFold – – No map 0.418 No Hit 0.0% —
3403 KP13_02982 putative HTH-type transcriptional regulator AlphaFold + ColabFold –
GO:0006355Any process that modulates the frequency, rate or extent of cellular DNA-templated transcription. GO:0003700A transcription regulator activity that modulates transcription of gene sets via selective and non-covalent binding to a specific double-stranded genomic DNA sequence (sometimes referred to as a motif) within a cis-regulatory region. Regulatory regions include promoters (proximal and distal) and enhancers. Genes are transcriptional units, and include bacterial operons. GO:0003677Any molecular function by which a gene product interacts selectively and non-covalently with DNA (deoxyribonucleic acid).
No map 0.418 No Hit 0.0% —
3404 KP13_00831 Serine hydroxymethyltransferase glyA AlphaFold + ColabFold –
GO:0030170Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. GO:0035999The chemical reactions and pathways by which one-carbon (C1) units are transferred between tetrahydrofolate molecules, to synthesize other tetrahydrofolate molecules. GO:0004372Catalysis of the reaction: (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + glycine + H2O = (6S)-5,6,7,8-tetrahydrofolate + L-serine. +25 total
No map 0.418 Hit 57.0% 6.95e-42
3405 KP13_31495 Guanosine-5'-triphosphate,3'-diphosphate pyrophosphatase gppA AlphaFold + ColabFold
3.6.1.40
GO:0015974The chemical reactions and pathways resulting in the breakdown of guanine pentaphosphate (5'-pppGpp-3'), a derivative of guanine riboside with five phosphates. GO:0008894Catalysis of the reaction: guanosine 5'-triphosphate,3'-diphosphate + H2O = guanosine 5'-diphosphate,3'-diphosphate + phosphate. GO:0015970The chemical reactions and pathways resulting in the formation of guanine tetraphosphate (5'-ppGpp-3'), a derivative of guanine riboside with four phosphates. +25 total
No map 0.417 No Hit 0.0% —
3406 KP13_03954 S-formylglutathione hydrolase frmB AlphaFold + ColabFold
3.1.2.12
GO:0018738Catalysis of the reaction: S-formylglutathione + H2O = formate + glutathione + H+. GO:0046294The chemical reactions and pathways resulting in the breakdown of formaldehyde (methanal, H2C=O), the simplest aldehyde. GO:0005829The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. +14 total
No map 0.417 Hit 54.0% 5.84e-97
3407 KP13_03861 2Fe-2S ferredoxin-type domain-containing protein AlphaFold + ColabFold –
GO:0030170Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. GO:0030151Binding to a molybdenum ion (Mo). GO:0003824Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic. +25 total
No map 0.417 Hit 45.2% 1.36e-19
3408 KP13_03696 4-hydroxybenzoate transporter AlphaFold + ColabFold –
GO:0016020A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it. GO:0022857Enables the transfer of a substance, usually a specific substance or a group of related substances, from one side of a membrane to the other. GO:0055085The process in which a solute is transported across a lipid bilayer, from one side of a membrane to the other. +25 total
No map 0.417 Hit 33.3% 5.89e-09
3409 KP13_03100 hypothetical protein AlphaFold + ColabFold – – No map 0.417 No Hit 0.0% —
3410 KP13_02206 Glutathione-regulated potassium-efflux system ancillary protein AlphaFold + ColabFold –
GO:0009055A molecular function representing the directed movement of electrons from one molecular entity to another, typically mediated by electron carriers or acceptors, resulting in the transfer of energy and/or the reduction-oxidation (redox) transformation of chemical species. This activity is fundamental to various biological processes, including cellular respiration and photosynthesis, as well as numerous enzymatic reactions involved in metabolic pathways. GO:0010181Binding to flavin mono nucleotide. Flavin mono nucleotide (FMN) is the coenzyme or the prosthetic group of various flavoprotein oxidoreductase enzymes. GO:0003955Catalysis of the reaction: NAD(P)H + H+ + a quinone = NAD(P)+ + a quinol.
No map 0.417 Hit 39.5% 3.27e-08
3411 KP13_01624 Dihydroneopterin triphosphate pyrophosphatase nudB AlphaFold + ColabFold –
GO:0046656The chemical reactions and pathways resulting in the formation of folic acid, pteroylglutamic acid. GO:0019177Catalysis of the reaction: dihydroneopterin triphosphate = dihydroneopterin phosphate + diphosphate. GO:0008828Catalysis of the reaction: dATP + H2O = dAMP + H+ + diphosphate. +47 total
No map 0.417 Hit 30.6% 1.28e-07
3412 KP13_08655 tRNA-dihydrouridine synthase A dusA AlphaFold + ColabFold
1.3.1.91
GO:0017150Catalysis of the reaction: a 5,6-dihydrouridine in tRNA + NAD(P)+ = a uridine in tRNA + H+ + NAD(P)H. GO:0002943The process whereby a uridine in a transfer RNA is converted to dihydrouridine. GO:0008033The process in which a pre-tRNA molecule is converted to a mature tRNA, ready for addition of an aminoacyl group. +58 total
No map 0.416 Hit 32.1% 5.81e-08
3413 KP13_05545 Acetylornithine deacetylase argE AlphaFold + ColabFold
3.5.1.18
GO:0016787Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. GO:0046872Binding to a metal ion. GO:0009014Catalysis of the reaction: N-succinyl-LL-2,6-diaminopimelate + H2O = LL-2,6-diaminopimelate + succinate. +14 total
No map 0.416 Hit 23.6% 2.21e-08
3414 KP13_05399 Succinylornithine transaminase AlphaFold + ColabFold –
GO:0030170Binding to pyridoxal 5' phosphate, 3-hydroxy-5-(hydroxymethyl)-2-methyl4-pyridine carboxaldehyde 5' phosphate, the biologically active form of vitamin B6. GO:0008483Catalysis of the transfer of an amino group to an acceptor, usually a 2-oxo acid. GO:0006525The chemical reactions and pathways involving arginine, 2-amino-5-(carbamimidamido)pentanoic acid. +25 total
No map 0.416 Hit 37.1% 1.90e-06
3415 KP13_04876 Spermidine/putrescine-binding periplasmic protein potD AlphaFold + ColabFold –
GO:0015846The directed movement of polyamines, organic compounds containing two or more amino groups, into, out of or within a cell, or between cells, by means of some agent such as a transporter or pore. GO:0019808Binding to a polyamine, an organic compound containing two or more amino groups. GO:0042597The region between the inner (cytoplasmic) and outer membrane (Gram-negative Bacteria) or cytoplasmic membrane and cell wall (Fungi and Gram-positive Bacteria). +14 total
No map 0.416 No Hit 0.0% —
3416 KP13_02629 hypothetical protein AlphaFold + ColabFold – – No map 0.416 No Hit 0.0% —
3417 KP13_02534 putative transposase AlphaFold + ColabFold –
GO:0003676Binding to a nucleic acid. GO:0015074The process in which a DNA segment is incorporated into another, usually larger, DNA molecule such as a chromosome.
No map 0.416 No Hit 0.0% —
3418 KP13_02394 hypothetical protein AlphaFold + ColabFold – – No map 0.416 No Hit 0.0% —
3419 KP13_01933 hypothetical protein AlphaFold + ColabFold –
GO:0046325Any process that stops, prevents, or reduces the frequency, rate or extent of the import of the hexose monosaccharide glucose into a cell.
No map 0.416 No Hit 0.0% —
3420 KP13_00210 rhodanese-like domain-containing protein AlphaFold + ColabFold – – No map 0.416 No Hit 0.0% —
3421 KP13_00202 ADP-L-glycero-D-manno-heptose-6-epimerase hldD AlphaFold + ColabFold
5.1.3.20
GO:0008712Catalysis of the reaction: ADP-D-glycero-D-manno-heptose = ADP-L-glycero-D-manno-heptose. GO:0050661Binding to nicotinamide-adenine dinucleotide phosphate, a coenzyme involved in many redox and biosynthetic reactions; binding may be to either the oxidized form, NADP+, or the reduced form, NADPH. GO:0005975The chemical reactions and pathways involving carbohydrates, any of a group of organic compounds based of the general formula Cx(H2O)y. +25 total
No map 0.416 Hit 25.4% 4.21e-06
3422 KP13_06918 hypothetical protein AlphaFold + ColabFold – – No map 0.415 No Hit 0.0% —
3423 KP13_05734 hypothetical protein AlphaFold + ColabFold – – No map 0.415 No Hit 0.0% —
3424 KP13_05378 Phosphatase AlphaFold + ColabFold –
GO:0016787Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc. GO:0000287Binding to a magnesium (Mg) ion.
No map 0.415 Hit 27.0% 2.23e-10
3425 KP13_05088 Succinyl-CoA:3-ketoacid-coenzyme A transferase subunit B lpsJ AlphaFold + ColabFold –
GO:0008410Catalysis of the transfer of a coenzyme A (CoA) group from one compound (donor) to another (acceptor).
No map 0.415 Hit 49.8% 2.59e-69
Page of 208 · 5192 total proteins